Ten years (!) after submitting the grant, NextBrain is published in @Nature . NextBrain is a brain atlas built from 3D histology that enables segmentation of 3D brain scans (MRI, Hip-CT, even photos!) into hundreds of regions. Article, data, code, videos, & more in this 🧵 (1/3)

Delighted to share that the preprint is now published: https://t.co/8eVjcUit7G @ChenZhang_NUS @anlijuncn @kimnganngt @AgingMacc @HelenJuanZhou @csabaorban

Online now: The brain neurovascular epigenome and its association with dementia

Aging happens in bursts, not gradually In a multi-omics study, only 6.6% of molecules changed linearly. 81% showed nonlinear changes with two dramatic waves: Age 44: cardiovascular, lipid/alcohol metabolism Age 60: immune dysfunction, carbohydrate metabolism

Genomic variants in the LDL receptor are the big driver of atherosclerosis, but most were previously unclassified for their impact. Today @ScienceMagazine nearly all 17,000 variants (!) were assessed functionally, which markedly improves the diagnosis for familial high

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway https://t.co/rPTzliIcSQ

A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels @lydianeH @matthiasvanosch @DeikeKaterina @mri_lumc https://t.co/WkBop17ecZ

A hypothalamus-brainstem-heart circuit regulated by oxytocin on heart rate variability. Another cool brain-body work!

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 https://t.co/x3KbEcEawP #Neuroscience #Psychedelics #BrainImaging

Amazing paper. All the good stuff: brain dynamics, state trajectories, embedding, links to arousal, tracking full dynamic state with a single measurement. https://t.co/N0zbt1Ebob

Large-scale cortical functional networks are organized in structured cycles | Nature Neuroscience https://t.co/cQBmNhpRBE

Using 4570 longitudinal MRIs + 1684 Aβ PET scans from cognitively healthy older adults, @james_m_roe find cortical thickness changed ≥7 years before PET-detectable Aβ. Those who later developed high Aβ already had thicker cortex & less thinning. @LCBC_uio

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see paper, thread https://t.co/8bdB2pXxQa

🚨 New Preprint 🚨 Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects By Cyr et al. Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via ES? A: Yes! 🧵:

Thrilled to share our latest work just published in @Nature where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS)! Full thread below 👇

Super thankful to @bttyeo @csabaorban and @ZShaoshi for pouring in all the effort to make this work possible!

1/11 Excited to share our @Naturestudy led by @Leon_Oo1 @csabaorban @ZShaoshi https://t.co/z51pMIGR5R It is well-known that AI performance scales with logarithm of sample size (Kaplan, McCandlish 2020), but in many domains, sample size can be # participants or # measurements...

Analyses from the largest neurodegeneration focused proteomics database - the Global Neurodegeneration Proteomics Consortium @_neuroproteome are published today in @NatureMedicine and @NatureAging The findings reveal unique protein biomarkers that correlate with

(1/10) How do brain networks and cognition co-evolve as children enter adolescence? While valuable, cross-sectional studies offer only a single snapshot of brain–cognition relationships, missing the dynamic changes that longitudinal designs can reveal. We hypothesize that

New in @NatureMedicine: ReSPCT "An international Delphi consensus for reporting of setting in psychedelic clinical trials" by @ChloePronovostM, Kyle Greenway, myself, and many ReSPCT Experts. "The ReSPCT guidelines and accompanying explanatory document provide a new standard for