Lijun AN | 安丽军
@anlijuncn
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Postdoc@Jacob Vogel ⬅️ PhD@Thomas Yeo. Neurodegenerative Disease, Brain Imaging, Machine Learning, Multi-omics
Sweden
Joined December 2018
Can AI reveal the risk and co-pathology of multiple neurodegenerative diseases from just a single blood sample? We explored the AI-based diagnostic power on a massive sample (N=17,170) and high-rank plasma proteomics data. https://t.co/kgBbWGVWAP
#MedSky #neuroskyence #neurosky
medrxiv.org
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathol...
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Ten years (!) after submitting the grant, NextBrain is published in @Nature . NextBrain is a brain atlas built from 3D histology that enables segmentation of 3D brain scans (MRI, Hip-CT, even photos!) into hundreds of regions. Article, data, code, videos, & more in this 🧵 (1/3)
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Delighted to share that the preprint is now published: https://t.co/8eVjcUit7G
@ChenZhang_NUS @anlijuncn @kimnganngt @AgingMacc @HelenJuanZhou @csabaorban
onlinelibrary.wiley.com
We introduced a simplified variant of FROG, the winning algorithm of the TADPOLE challenge, for predicting dementia progression using multimodal longitudinal data. Combining the longitudinal-to-cro...
🚨 Predicting Alzheimer's Progression 🚨 A thread 🧵 1/ Accurate prediction of Alzheimer’s progression is critical for early intervention. How can we make predictions more precise and generalizable? 🧠✨ 📝 Read the preprint led by @ChenZhang_NUS : https://t.co/vxbpjGG4GC
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🚨 Predicting Alzheimer's Progression 🚨 A thread 🧵 1/ Accurate prediction of Alzheimer’s progression is critical for early intervention. How can we make predictions more precise and generalizable? 🧠✨ 📝 Read the preprint led by @ChenZhang_NUS : https://t.co/vxbpjGG4GC
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Online now: The brain neurovascular epigenome and its association with dementia
cell.com
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and...
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Postdoctoral Positions Available in Cognitive Neuroscience and Brain Network Research Location: Zhejiang University, Hangzhou, China https://t.co/0ByOKzY7J6
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NEJM: ~1–3% of patients in MS, IBD & AD trials were likely misdiagnosed and actually had a rare disease. Small numbers, but such misclassification could subtly confound observed treatment effects. Similar approaches could be used to identify potential misdiagnoses and refine
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How crazy it is?!
Congratulations @Yoshua_Bengio!! Possibly the first scientist with one million citations in the world. Crazy how fast the field has grown 🤯
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Announcing our much-awaited updated aladynoulli, a fully interpretable Bayesian model that considers predictive and explanatory disease trajectories across the life course for individuals, anchored on underlying PGS.
medrxiv.org
Understanding how disease patterns evolve over a lifetime remains a key challenge in medicine. While electronic health records provide rich longitudinal data, existing models typically analyze each...
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Excited to put the cherry on the top for our multi-organ, multi-omics biological aging clock work: After developing 3 brain MRI-based clocks (MRIBAG), 9 phenotype-based clocks (PhenoBAG), 11 proteome-based clocks (ProtBAG), 5 metabolome-based clocks (MetBAG), we have now
nature.com
Nature Medicine - A new study combines MRI data with proteomic, metabolomic and RNA data to develop and examine seven organ-specific MRI-based aging clocks, uncovering links to overall mortality...
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A human pan-disease blood atlas of the circulating proteome https://t.co/YDBhXhsewS
science.org
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of...
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🚨 Thrilled to share that our paper Brain Harmony (BrainHarmonix) has been accepted at #NeurIPS2025! We introduce the first multimodal brain foundation model that unifies structure 🧠 (MRI morphology) & function ⚡️ (fMRI dynamics) into compact 1D brain tokens. Paper:
arxiv.org
We present Brain Harmony (BrainHarmonix), the first multimodal brain foundation model that unifies structural morphology and functional dynamics into compact 1D token representations. The model...
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Our new paper is out now in Neuron!🎉 With @vaibhav_3pathi @max12elliott @jladopoulou @wendysun23 Mark Eldaief and @RandyLBuckner Link: https://t.co/D8bGjWGqBD
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Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | Neuron https://t.co/qteZvRdTWx
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Now online! Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis
cell.com
Multiscale proteomic network modeling of Alzheimer's disease integrates large-scale proteomic and genetic data from vulnerable brain regions and reveals key driver proteins such as AHNAK within a...
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@UBC_Psychiatry @UBC_IMH If you missed @rubykong92 's wonderful talk today, , you can now watch it on our channel
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Join our 15th event on September 23! We're thrilled to welcome Dr. @rubykong92 from National University of Singapore to introduce their work on "Individual-specific Brain Parcellations for Clinical Applications". Scan the QR code to participate for free! @UBC_Psychiatry
@UBC_IMH
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Brain clocks are modulated by disease, exposome, genetics, & whole-body health. But what are the underlying mechanisms? Clocks estimate biological age, not the underlying processes. We tackle this through biophysical modeling in aging and dementia🧵1/5: https://t.co/mPHd40MuEV
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My first book with @ShaoXingfeng on Imaging BBB Dysfunction in Brain Disorders is online for pre-order, it summarizes BBB biology, foundations and clinical uses of cutting edge imaging technologies for mapping BBB function in a healthy and diseased brain
📢 Now available for pre-order: Imaging Blood-Brain Barrier Dysfunction in Brain Disorders by our very own @loft_lab & @ShaoXingfeng! This new volume explores the blood-brain barrier’s critical role in brain health and disease 📚🧠 https://t.co/2bTZ9VJDmf
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A brief self-administered digital #cognitive test, in combination with a blood test, accurately detects clinical #Alzheimers disease in #PrimaryCare. #DigitalHealth #AlzheimersAwareness @OskarHansson9 @karlssonlinda1 @biofinder_study
https://t.co/riBsrrbxQI
nature.com
Nature Medicine - A brief, self-administered digital cognitive test, in combination with a blood test, accurately detects clinical Alzheimer’s disease in primary care.
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🚨New publication in Nature Medicine! In this study, we demonstrate that a brief, self-administered cognitive test battery can reliably identify individuals with cognitive impairment in a primary care setting. Details: https://t.co/tSwVYOlzWS Full paper:
nature.com
Nature Medicine - A brief, self-administered digital cognitive test, in combination with a blood test, accurately detects clinical Alzheimer’s disease in primary care.
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