Chirag Krishna
@chirag_msk
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@pfizer systems immunology
Cambridge, MA
Joined December 2017
RT @KlebanoffLab: 🤯Three (!!!) new papers today in @ScienceMagazine on the application of generative AI for the de novo design of peptide/H….
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RT @Steph_Gaglione: Thrilled to share our preprint! We introduce TCRAFT, a method to assemble tens of thousands of TCRs at <$1 each, unlock….
biorxiv.org
T cell receptors (TCRs) mediate antigen recognition in adaptive immunity, yet large-scale mapping of TCR-antigen interactions remains a major challenge. Current approaches to synthesize and functio...
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RT @jhumimmunity: Poli et al. present the 2024 update of the @iuis_online classification of human #InbornErrorsOfImmunity including 67 nove….
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RT @EricTopol: Who would benefit from checkpoint inhibitor immunotherapy for cancer?.A machine learning model based on routine lab tests an….
nature.com
Nature Medicine - Using multiple datasets from real-world evidence and completed trials, a machine learning model using routine blood and clinical data is shown to be predictive of patient response...
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RT @EricTopol: There is an increased risk of autoimmune diseases after Covid, and 2 constituents of the virome (anellovirus and HHV-6) may….
nature.com
Nature Genetics - Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most...
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RT @BogunovicLab: What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? .Latest from us. Published today. News here https://….
cuimc.columbia.edu
A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.
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RT @michelson_da: Excited to share our latest work on the thymus, out @ImmunityCP! We define thymic mimetic cells in humans and show they a….
cell.com
Thymic mimetic cells are chimeras between medullary-thymic-epithelial cells (mTECs) and peripheral cell types. Huisman, Michelson, et al. perform high-resolution profiling of human mimetics, reveal...
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RT @ImmunityCP: Online now: Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis https….
cell.com
Aberrant immune signal strength in B cells is associated with autoimmune diseases and lymphoma. Diehl et al. show that hyperreactive B cells trigger cytotoxic T cell-mediated elimination. Less...
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RT @VMallajosyula: Thrilled to share our latest work on broadening T cell help for developing better flu vaccines @ScienceMagazine @sarah_h….
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RT @PossuHuangLab: 1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens. TRACeR f….
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Excited to share our HLA-pQTL study revealing widespread HLA trans effects on protein expression in @uk_biobank- now out at @NatureComms with @xinlisea, @JoshChiou, @soumya_boston, @saorisakaue, @joycebkang, and many more @pfizer!.
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Thrilled to share our latest work out now in @ScienceMagazine demonstrating a heterozygote advantage at HLA-II in protecting against lung cancer risk in smokers!. Check out @diegochowell’s tweetorial below👇.
Does the immune system protect against cancer?.Today our study on HLA immunogenetics and lung cancer risk has been published in @ScienceMagazine led by @chirag_msk @AnniinaTervi @MiriamSaffern @EricWil39327976 @HannaMOllila @rsamstein
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RT @BenniRuf: 🥳🥳🥳Couldn't be happier to see our study on mucosal-associated invariant T (MAIT) cells in HCC published today in @CellCellPre….
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RT @vagheesh: Always been a bit surprised by the low % of colocalization of eQTLs and GWAS hits. One rationale is that we weren’t looking a….
biorxiv.org
Disease-associated loci discovered through genome-wide association studies (GWAS) are primarily located in non-coding regions with putative regulatory effects on gene expression[1][1]. Steady-state,...
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These fine-mapped HLA-pQTL have important implications for our understanding of HLA biology and the mechanisms underlying immune-mediated diseases. Very grateful to all of our amazing co-authors- @JoshChiou , @soumya_boston, @saorisakaue, and many more!.
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Excited to share our HLA-pQTL study from @pfizer with @xinlisea- we show that disease-associated HLA alleles exert widespread trans effects on plasma protein expression using data from @uk_biobank @OlinkProteomics- 45K individuals, 2940 proteins!.
biorxiv.org
Polymorphism in the human leukocyte antigen class I (HLA-I) and class II (HLA-II) genes is strongly implicated in susceptibility to immune-mediated diseases. However, the molecular effects of HLA...
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RT @ChristaCaggiano: Our work on fine-scale identity-by-descent clusters in the UCLA ATLAS Biobank was published online today! I'm immensel….
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RT @LMackayLab: Exciting news from our lab! 🧵👇 Our latest study on tissue T cell heterogeneity, led by @maxevrard is now published in @Immu….
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RT @JExpMed: Chancellor, Simmons, De Libero @UniBasel_en, Lepore et al. show that promiscuous recognition of MR1 by canonical MAIT TCRs end….
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RT @BourgonjeArno: Very happy to announce that today two papers on #PhIPSeq in (1) the general population (🧵 by @sea_andreu) and (2) in pa….
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