
Christopher Bohrer
@cbohrer3141
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Postdoc at NIH/NCI, Ph.D. @Hopkins
Joined January 2013
I've always been obsessed with how genes and enhancers talk to each other. Our latest review explores just that. Enhancers: A Focus on Synthetic Biology and Correlated Gene Expression | ACS Synthetic Biology .
pubs.acs.org
Enhancers are central for the regulation of metazoan transcription but have proven difficult to study, primarily due to a myriad of interdependent variables shaping their activity. Consequently,...
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RT @Eric_Betzig: Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light she….
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RT @MariosGeorgakis: 17,186 genes were differentially expressed between biopsy-derived brain tissue from 275 living patients and 243 postmo….
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RT @NikoMcCarty: A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a….
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RT @MuzumdarLab: 💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding patte….
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RT @rooij_laura: 🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built….
biorxiv.org
Endothelial cells (ECs) are critical regulators of vascular function and exhibit specialized, organ-specific roles across tissues. During aging, these cells become dysfunctional, resulting in...
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RT @xashleefeng: A brief summary/perspective on my recently published PhD work: Nucleosomes constrain 1D DNA diffusion by eukaryotic transc….
nature.com
Nature Structural & Molecular Biology - The transcription factor GAGA factor (GAF) recruits chromatin remodelers to establish and maintain open chromatin for transcription in Drosophila...
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RT @SStevenWang: Glad to share our latest publication in Nature Genetics @NatureGenet: Tracing the evolution of single-cell 3D genomes in K….
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RT @xielablife: Happy to share our work on how chromatin organization is established for the first time in early mouse embryos, in part via….
nature.com
Nature - A study reveals progressive cohesin loading and a hypertranscription state responsible for the formation of genic cohesin islands at active regulatory genes in mouse embryos, highlighting...
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RT @ericjoycelab: 🚨New preprint from the lab🚨.🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide….
biorxiv.org
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their...
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RT @luigiadamomdphd: Preload deficiency is a treatable cause of fatigue and exercise intolerance in SLE This coll….
thelancet.com
Fatigue and exercise intolerance affect more than 90% of patients with systemic lupus erythematosus (SLE), often persisting despite inactive disease.1 The pathophysiology of the disease remains...
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RT @biorxiv_genomic: Molecular co-accessibility identifies coordinated regulation between distant cis-regulatory elements .
biorxiv.org
In metazoans, gene expression is typically regulated by a cis -regulatory landscape (CRL) composed of a promoter and multiple enhancers. How these cis -regulatory elements (CREs) coordinate their...
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RT @eLife: A simple flow of gas over water may have helped kickstart life on early Earth. Research shows how evaporation and fluid flow in….
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RT @PRX_Life: In our first review, scientists revisit how physical forces shape collective #AnimalBehavior, revealing how individual-enviro….
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RT @slavov_n: How challenging is the prediction of transcriptional responses to CRISPR gene perturbations ? . A simple model, just scaling….
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RT @FSchueder: 🔬🧬 New in @NatureComms: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohe….
nature.com
Nature Communications - A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give...
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RT @taekjip: A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics | Nature Structural & Molecular Biology….
nature.com
Nature Structural & Molecular Biology - Gene activity levels predict how often and how strongly genes turn on and off. Using live imaging in fruit fly embryos, the authors uncover a conserved...
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RT @luigiadamomdphd: Analyzing human myocarditis at the tissue transcriptomics levels, with two different platforms, we found that the dise….
biorxiv.org
Background Myocarditis is an inflammatory disease of the myocardium, classically defined and graded by histologic criteria that emphasize immune infiltrates and focal cardiomyocyte injury. The...
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RT @arjunrajlab: Very excited to share our new work on gastruloids by the incredible @ugcgccacc! We mapped gene expression across 26 indivi….
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RT @FukayaLab: Delighted to share a new review paper from the lab. We discussed recent key findings in enhancer biology. Thanks Dan Larson….
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RT @biorxiv_genomic: Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues #biorxiv_genom….
biorxiv.org
The spatial resolution of omics dynamics is fundamental to understanding tissue biology. Spatial profiling of DNA methylation, which is a canonical epigenetic mark extensively implicated in transcr...
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