Ben Jacobs
@ben_m_jacobs
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RT @EricTopol: The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence."impl….
nature.com
Nature - Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a...
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RT @uk_biobank: Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform rese….
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Thanks Joe! I’ll be honest we were mildly disappointed to find no ‘smoking gun’, I.e a disease-specific signature of clonal expansion. For me has highlighted how valuable it is to have positive disease controls to avoid making spurious claims of disease specificity!.
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V pleased to share our paper on the immune landscape of CSF in MS and other conditions now out in @CellRepMed. Fun and stimulating collaboration with co-first author @ChristieGasperi and senior authors Maria Ban, Steve Sawcer and Bernhard Hemmer.
cell.com
Jacobs, Gasperi et al. probe the immune landscape of cerebrospinal fluid in multiple sclerosis and other neuroinflammatory disorders. By combining single-cell gene expression with lymphocyte receptor...
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RT @MSJ_Research: There is discrepancy between self-reported and objectively assessed cognitive functioning in #MultipleSclerosis, suggesti….
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RT @Winchy_l: Looking for new post doc role in 2026? 3 year contract working on proteomic data for AD and PD in Oxford. Do get in touch wit….
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RT @uk_biobank: ✅ The UKB-RAP Transition Credits Programme is now open!. Thanks to @wellcometrust, researchers can apply for £1,000 credits….
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RT @jakphd: The newest @RegeneronDNA method, REMETA, from Tyler Joseph, @marchini, and co. is a game changer - enabling the ability to reco….
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RT @marchini: Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) @RegeneronDNA for meta-analysis of gene-based….
medrxiv.org
Meta-analysis of gene-based tests using single variant summary statistics is a powerful strategy for associating genes with disease. However, current approaches require sharing the covariance matrix...
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RT @MariosGeorgakis: Tandem repeats (TR) are usually underxeplored in genetic studies🧬. Here, a PheWAS of TRs in UK Biobank .👉N=168,554.👉47….
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RT @Inga_genetics: 📢Please, RT: do you need to run GWAS, their imputation/meta-analyses/follow-up, PRS & MR? Apply for Short online live co….
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🔥.
This is an incredible resource!.
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RT @andywdahl: GxDrug interactions now published at cell genomics :) @sadowskimich did a ton of great work in this paper. We hope the appro….
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RT @joe_pickrell: "GWAS of Extended Prescription Analgesic Use Identifies Novel Genetic Loci in Chronic Pain"
medrxiv.org
Pain-related conditions are the leading cause of disability worldwide. Current genome-wide association studies (GWAS) for chronic pain have mainly focused on individual pain-related disorders, which...
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RT @HuntLabEdin: Please RT! This was such an enjoyable event last year. Registration now open. Free registration for early careers research….
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RT @doctorveera: One of the strongest risk loci for SLE lies on the MHC region. Earlier work by Steve McCarroll's group (Kamitaki et al Nat….
nature.com
Nature - Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of...
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RT @ewanbirney: This is great news (COI: I am a long established consultant and shareholder to @nanopore) - epigenetic information on long….
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RT @NatureMedicine: In a cohort of 51,170 South Asians, #PolygenicRiskScores identified genetic susceptibility to insulin deficiency and fa….
nature.com
Nature Medicine - In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key...
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