Balazs Papp lab
@balazs_papp_lab
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We are interested in evolution and systems biology, including the evolution of metabolism, antibiotic resistance and compensatory evolution.
Szeged, Hungary
Joined March 2022
What's the secret to minimizing antibiotic resistance? Our joint work with @Csaba_Pal_Lab reveals membrane-targeting antibiotics that simultaneously block another cellular pathway are key. Check out thread below. #ESKAPE pathogens #Antibiotics.
🚨 Our latest research in @NatureComms shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here:
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ESKAPE pathogens are outsmarting us. Our latest paper in @NatureMicrobiol reveals alarming ease of resistance evolution to antibiotics in development. Collaborative work with @Csaba_Pal_Lab and @KintsesLab.
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is just published in @NatureMicrobiol. For details, see the 🧵below and read the paper here:
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Excited to share our joint work with @Csaba_Pal_Lab on the resistance propensity of new antibiotic candidates. Just out in @ScienceTM.
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in @ScienceTM! For details, see the thread below and read the paper here:
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Excited to share our latest collaborative work led by @TheBraunLab! Huge congrats to all authors, including our amazing postdoc @SarkadiZsuzsa, who is a co-first author.
Thrilled to announce that an advanced version of our study is now published in @NAR_Open! 🚀 Huge thanks to the reviewers for insightful comments and @SarahLa47195747 for invaluable contributions during the revision process. 🙌 Read more here:
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RT @ddelneri: Great to be part of the magnificent 7 team, and great to collaborate again with Steve Oliver after 16 years! @FutureBRH @UoM….
nature.com
Nature Communications - The construction of minimal metabolic networks contributes to our understanding of metabolism and biotechnological processes. Here, Jansen et al. have defined a class of...
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Excited to share this new R tool for enrichment analysis. Led by @EszterAri and team.
Happy to share our new paper about the mulea R package dedicated to enrichment analysis, using a resampling based false discovery rate, and applying multiple ontologies (which we collected for many species).
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RT @EszterAri: Happy to share our new paper about the mulea R package dedicated to enrichment analysis, using a resampling based false disc….
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Our recent story covered by @GENbio.
First "Superbug Map" May Advance Phage Therapy for Acinetobacter baumannii . Scientists have created a global "superbug map," paving the way for scalable #phagetherapy to combat antibiotic-resistant infections in hospitals.
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Excited to share our joint work with @zkutalik’s lab on #metabolic #evolution, just published in @genomeresearch!.We found pervasive stabilizing selection on metabolite levels in human, reflecting their impact on clinical phenotypes.
Excited to share our first steps towards understanding stabilising selection mechanisms in metabolites:
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Our new paper in @CellCellPress harnesses the power of pathogen genomic epidemiology to transform phage therapy. Result of an amazing collaboration with the @KintsesLab and many partners.
📢 Thrilled to announce our latest research in @CellCellPress! We've created a global ‘superbug map’ for a critically antibiotic-resistant bacterium to inform #phagetherapy 🧵1/11
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Did you know ascorbate is more than just an antioxidant? Our new research with Szilvia Toth's lab reveals its crucial role in regulating plant metabolism.
Chloroplastic ascorbate modifies plant metabolism and may act as a metabolite signal regardless of oxidative stress (Dávid Tóth, Roland Tengölics, Fayezeh Aarabi, Anna Karlsson, André Vidal-Meireles, László Kovács, et. al.) @ASPB #PlantSci
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RT @RalserLab: Many will remember heavy debates in the yeast aneuploidy field. Are excess proteins dosage compensated, and if, how? Are the….
nature.com
Nature - Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal...
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Funding opportunities for life scientists in Hungary - Special @EMBO information session in Budapest at.HUN-REN Research Centre for Natural Sciences
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RT @HittingerLab: The big Y1000+ Project manuscript is finally published in Science magazine! Years of work with @RokasLab, @DOpulente, @La….
science.org
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i)...
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Thrilled to hear Csaba Pal just landed an ERC Advanced Grant! So well-deserved. We're excited to collaborate further on antibiotic resistance and more.
We are happy to announce that Csaba Pál received the ERC Advanced Grant! Huge congratulations!.#ERCAdG . @ERC_Research @Csaba_Pal_Lab.
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RT @mitchell_sysbio: Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest wo….
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RT @sllsi: What would evolutionary biology look like today if Darwin had spent his life staring down the barrel of a microscope? (or the sc….
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RT @jo_schacherer: Most Saccharomyces cerevisiae genomes are in fact distributed on different websites. Great effort to gather, assemble a….
journals.asm.org
Saccharomyces cerevisiae (baker’s yeast, budding yeast) is one of the most important model organisms for biological research and is a crucial microorganism in industry. Though a huge number of...
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RT @laszlognagy: Contamination in published genomes is widespread. We present a new HGT-aware tool for decontamination, ContScout, publishe….
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RT @liti_nice: super happy to share our latest work @niceyeastlab on the evolution of shared alleles across yeast species led by @nicolo_te….
nature.com
Nature Ecology & Evolution - Analysis of 1,673 sequenced Saccharomyces cerevisiae isolates identifies 3,852 sequence blocks introgressed from Saccharomyces paradoxus, most of which are recent...
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