Danny JJ Wang
@loft_lab
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Professor of Neurology and Radiology @USC, Director of LOFT lab
Los Angeles
Joined January 2023
High resolution iso-1mm 7T ASL allows assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex
biorxiv.org
Understanding how cellular architecture organizes cortical function requires mesoscopic approaches that resolve structure-function coupling in vivo. Here we introduce cerebral blood flow (CBF) and...
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Happy to share our analysis results of ADNI-3 ASL data, showing consistent trend of CBF decrease with AD progression in key AD related brain regions in both GE and Siemens ASL data https://t.co/NvVcUl6oFv
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Happy to join special session at #ESMRMB2025 on low field MRI co-organized by CAMERA and OCSMRM
Saturday’s CAMERA–OSCMRM session “Low-Cost Open Source MRI: Are We There Yet?” at #ESMRMB2025 brought diverse insights on open-source MRI — from hardware development to radiology and education. Thanks to our speakers for thoughtful talks and discussion! #LowFieldMRI #OpenSource
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Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕ "It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://t.co/L9cA1BH4qi
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Glad to share our new paper in Nature Cardiovascular Research https://t.co/14UFbALL5O introducing a new method for mapping microvascular pulsatility using high resolution VASO and ASL MRI at 7T @layerfMRI
🚨 New discovery 🚨 Our @loft_lab developed a noninvasive brain-imaging method that reveals hidden microvascular pulsations in aging brains, which may offer earlier clues into dementia and Alzheimer’s risk. Read the press release here: https://t.co/gWhak1o15z
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A single aquaporin protein lets one billion water molecules into a cell each second. It is one of the "fastest" channels in all of biology. Each water flows through in single file, while H+, sodium, potassium, and other ions are excluded. What explains this remarkable
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My first book with @ShaoXingfeng on Imaging BBB Dysfunction in Brain Disorders is online for pre-order, it summarizes BBB biology, foundations and clinical uses of cutting edge imaging technologies for mapping BBB function in a healthy and diseased brain
📢 Now available for pre-order: Imaging Blood-Brain Barrier Dysfunction in Brain Disorders by our very own @loft_lab & @ShaoXingfeng! This new volume explores the blood-brain barrier’s critical role in brain health and disease 📚🧠 https://t.co/2bTZ9VJDmf
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Focused ultrasound with microbubbles can safely open BBB and the effect can be detected using DP pCASL MRI without contrast agent. Checkout the video and our preprint
biorxiv.org
This study applied diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) to quantify cerebral blood flow (CBF), arterial transit time (ATT), and blood-brain barrier (BBB) water...
📽️ New week, new animation with data from @loft_lab! Focused ultrasound with microbubbles can temporarily open the blood-brain barrier, enabling noninvasive, targeted drug delivery while minimizing risk 🧠 Stay tuned for something big coming out of @loft_lab 👀
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Focused ultrasound induced BBB opening in the Dorsal Striatum of Non-Human Primates can be detected by BBB water exchange imaging using DP pCASL
biorxiv.org
This study applied diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) to quantify cerebral blood flow (CBF), arterial transit time (ATT), and blood-brain barrier (BBB) water...
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The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
science.org
Republicans on spending committee push back against proposed reorganization and overhead cuts
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Honored to attend SMART Africa MRI workshop focusing on ASL in Lagos Nigeria 🇳🇬 impressed by the growth and passion of MRI in Africa, glad to share ASL experience and contribute to global MRI, congrats to @SMARTA_NETWORK
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The 3rd annual meeting of 7T Translational Alliance of North America (7TANA) was successfully held at UTSW July 14-15 2025, great progresses in multiple frontiers of 7T clinical translations. Congrats to organizers Dr. Anke Henning and Sheeba Anteraper at UTSW see y'all next year
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ASL CBF changes with AD stages, indicating the value of ASL for detecting and monitoring AD progression
🌟 New week, new animation 🧠 Research by our @loft_lab uses noninvasive ASL MRI to show that brain blood flow decreases even in the earliest stages of Alzheimer’s — before memory problems appear. This could help doctors catch the disease earlier and track treatment over time.
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Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal | Science
science.org
Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function...
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Mondays are for experimenting with visualizing a single subject Human Connectome Project dataset of the full brain fiber bundles 🤩🧠
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Thanks for @audreypfan invite to visit UC Davis BME and imaging research center, impressive program great exchange with faculty and students, beautiful campus with an arboretum also thx @ydavidzhu
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Nice to attend #ASNR2025 ultrahigh field MRI in clinical neuroradiology session with @EMiddlebrooksMD @CanOzutemiz Dr Mai-Lan Ho and @PaechDC
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Alzheimer’s Disrupts the Whole Body, Not Just the Brain New research shows that Alzheimer’s disease impacts not only the brain but also other organs throughout the body. Using genetically modified fruit flies that expressed Alzheimer’s-related proteins Aβ42 or Tau in neurons,
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Congrats to class 2025 of ISMRM junior and senior fellows, gold medalists especially to my mentor Dr Detre for winning gold medal 🥇 well deserved for career achievement
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Thank you @60Minutes for giving the devastating NIH pauses and proposed budget cuts the attention they deserve. ALL Americans regardless of party affiliation will be impacted, and the impact goes long beyond one administration.
cbsnews.com
Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans’ health.
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