Adam Nitido
@adamnitido
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Virologist | Research Fellow @ Ragon Institute
Cambridge, MA
Joined December 2019
'Virology—The next fifty years' - a perspective by Eddie Holmes, @GoodrumVirusLab and myself in Cell https://t.co/jOJWY6BPqI
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QuickFit: A high-throughput RT-qPCR-based assay to quantify viral growth and fitness in vitro https://t.co/BAo86k8Ulg
#biorxiv_micrbio
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Our preview of a new paper describing the development of a new mRNA vaccine against mpox is now available online. Thanks to @adamnitido for the great team effort putting this together! https://t.co/6f2wLRtoxs
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New pre-print from the lab🥳🥳!! Amazing team effort between @DouamLab, @BalazsLab and Christelle Harly's group in Nantes. Congrats to @DevinKenney10 for spearheading the work.
biorxiv.org
The lung-resident immune mechanisms driving resolution of SARS-CoV-2 infection in humans remain elusive. Using mice co-engrafted with a genetically matched human immune system and fetal lung xenogr...
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Ever wonder why despite the extreme mutation rates of RNA viruses, diversity in nature is concentrated in a few viral proteins? Could it be because viral proteins have different abilities to tolerate mutations? Our full proteome DMS study looks at this! https://t.co/z0bD9Xz5p8
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I will be defending my Ph.D. dissertation (via zoom) on August 24 at 11AM ET! If you want to watch it, send me a DM, and I'll share with you the link.
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Our preprint is live! We find that IgG antibody subclass has a big influence on protective efficacy of VRC07 broadly neutralizing antibody against vaginal HIV transmission in humanized mice. We also show that even a little VRC07 yields protection in vivo. https://t.co/CLa4Spo2wa
biorxiv.org
HIV broadly neutralizing antibodies (bNAbs) are capable of both blocking viral entry and recruiting innate immunity to HIV-infected cells through their fragment crystallizable (Fc) region. Vaccinat...
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We are looking to recruit new techs to join the lab and help us engineer immunity against SARS-CoV-2 and HIV infection! If you are passionate about virology and immunology and want to be part of creating the next-generation of interventions please apply! https://t.co/TXtQGfpRO2
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Our method to improve confidence and prevent common errors in SARS-CoV-2 sequencing is out in @NatureMicrobiol. What started as a pandemic scramble to help out in some way, turned into project and team I am so proud to be part of! https://t.co/Eq4hbstFpm a brief overview: (1)
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Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to @wilfredo_nk, @kstdenis29, @EvanCLam, @adamnitido, @NaranbhaiVivek who have been up at all hours of the night both at the bench and writing the paper! 1/16
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First day of #HumanViruses Dynamics & Evolution conference. I’ll give a flavour in the thread below. HIV & SARS-CoV-2, sequencing & modelling & immunology. Talks listed here https://t.co/gILJIqSsNJ. Organisers @manonragonnet @sergeilkp @ucsandiegocme @ucsdcme 1/N
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If anyone is interested in reading the complete pre-print, it is now available for download on out lab's website:
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We have just uploaded a pre-print to MedRxiv sharing our data on the potential for sera from recipients of currently administered mRNA vaccines to neutralize 10 different circulating strains of #SARSCoV2. Before it posts online, I'd like to put them into context. A thread: 1/12
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At this point, the countries with most genomic data to analyze spread of the variant virus belonging to https://t.co/ImaHU6Jxdv B.1.1.7 lineage or @nextstrain clade 20I/501Y.V1 are the UK, Denmark and the USA. Here I compare growth rates of B.1.17 across these countries. 1/13
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We mapped how all mutations to #SARSCoV2 receptor-binding domain (RBD) affect recognition by convalescent polyclonal human sera ( https://t.co/fCJvAnXhs8). Among implications: E484K (South African lineage) worrying for immune escape; RBD mutations in UK lineage less so (1/n).
biorxiv.org
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent serum...
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Origin and cross-species transmission of bat coronaviruses in China
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Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time
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To beat #COVID19, its replication and transcription machinery has to be taken down. To do that well, we need to know its high-resolution #3D structure. Today we've got the cryo-EM. + tied to remdesivir, a promising drug https://t.co/cQ32LqXYf0
@ScienceMagazine h/t @hholdenthorp
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@just_security summarizes the COVID-19 @MassGeneral Grand Rounds, led by @brucedwalkermd, breaking down the key findings of the Greater Boston Consortium for Pathogen Readiness. @MGH_RI
https://t.co/yRQlJoyqxu
justsecurity.org
Key findings of top medical researchers on coronavirus at a first-of-its-kind virtual Grand Rounds.
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