Ayele A.Denboba
@a_denboba
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Gut microbiota, Gametogenesis, Epigenetic inheritance, Early life programming, Culturomics, Metabolomics |Group Leader @MPI-IE
Freiburg, Germany
Joined March 2021
Our 🔥 brand-new PhD program IMPRS-EBM at the intersection of #Epigenetics, #Biophysics & #Metabolism is open for applications📢. Looking for a fully-funded #PhDposition at Max Planck? Here is your chance: https://t.co/ZSxd4I9mbv
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Congrats @hackettlab @AnaBoskovic18 - definitely a landmark work setting the foundation for iGxE sufficient cause model - Kudos @MathildeJDura @bbbranjan!!🥂
📢 Preprint! Does the environment of a father before conception influence offspring? Even more, how do paternal genetics & age interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales https://t.co/THGgCcMQNL
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Our director Nicola Iovino (@Iovino_Lab) is expanding the lab. The team is looking for an experienced Postdoc with a strong focus in #bioinformatics. ⏱️ Application deadline: Nov. 20, 2024. Here is your chance: https://t.co/njbOIJ43MZ
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My lab is hiring a postdoc, don't hesitate to apply! Lots of opportunities to work on Hi-C/Micro-C and super-resolution imaging in Drosophila and mESCs.
📢 Job alert: Postdoc Position in the lab of Jumana AlHaj Abed (@JumanaAHA) – Fantastic opportunities at #MaxPlanck in #Freiburg to work on Hi-C & super-resolution imaging in #Drosophila and mESCs. Get all the details & apply until Sept. 27: https://t.co/HQa9hgoLYZ
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We're hiring new faculty at @emblebi - under the great @JulioSaezRod - we focus on vision and potential and you certainly don't have to be the finished article as a Postdoc (we even hire from last year of PhD) - so - into AI, methods with biological data - apply!
Apply as a research group leader! Lead an independent research group in computational biology, focusing on AI-biology interfaces. Enjoy core support and outstanding infrastructure. Explore EMBL's Molecules to Ecosystems vision, and more! https://t.co/08YxNqtRMX
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Hooray! We are #recruiting! Our Max Planck #gradschool #PhD program is looking for the next generation of talents in #epigenetics, #biophysics, #metabolism & many more areas. Get details about our @mpi_ie @UniFreiburg faculty & the application process: https://t.co/5yDUJLsmnw
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There's been a recent explosion of knowledge about various circuits within our body. Two black swans. It's not only fascinating, but has relevance for new approaches to diseases, health, and aging. Pulled together in a new Ground Truths post (link in profile)
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Another masterpiece work @hackettlab led by brilliant scientist @CristinaPolica4, devised precision epigenome editing to unravel the hierarchical logic of chromatin remodeling, Kudos @hackettlab @CristinaPolica4 & all colleagues!👏👏👏🥂 https://t.co/q6zVhuPfCz
nature.com
Nature Genetics - The authors develop and harness a suite of epigenome editing tools to explore the role of different epigenetic marks in modulating transcription. In particular, H3K4me3 deposition...
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A week of discoveries about our internal axes! —Gut to sperm https://t.co/xfK1sjvAhz —Body to brain https://t.co/4EmG9d0FlP —Brain to muscle https://t.co/lOTiLmRGrp —Brain to skin https://t.co/P0XChh3nmR
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Check out the groundbreaking research by @a_denboba! Their thorough investigation into the intergenerational impacts of paternal gut microbiome is a must-read for anyone intrigued by non-genetic inheritance and gut microbes. Congratulations @a_denboba
nature.com
Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.
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Our recent study on paternal effects of gut microbiome disruption is discussed in the always listenable @NaturePodcast
https://t.co/R8UuCQMgy6
nature.com
Nature - Hear the biggest stories from the world of science | 1 May 2024
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This was an incredible journey at @EMBLRome led by the legendary @a_denboba (now PI at Max Planck) Huge thanks to lab members and scientists that contributed @bbbranjan @TSBSchm #others Also massive support from collaborators @BorkLab @Zimmermann_Lab @PSarkies d
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For those interested in non-genetic heritability, this paper from @hackettlab demonstrates how these studies should be done in mammals. Outstanding work. https://t.co/0b204SdWTO
nature.com
Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.
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One of the most careful pieces of work done showing (single) intergenerational non DNA phenotype transfer in mammals, linking paternal gut microbiome to offspring’s health in mice by @hackettlab from @EMBLRome
The gut microbiome influences metabolites, hormones and immune function Perturbing gut microbiota therefore impacts homeostasis across somatic tissues Could it also affect the reproductive system - and even offspring? See our results👇& tweetorial🧵 https://t.co/lb6w6BjoW7
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Disturbances of the gut microbiomes of male mice may impact the health of their offspring, according to a study in @Nature. The research suggests that disrupted gut microbiomes in males may impact placenta function.
nature.com
Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.
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Our data highlight the importance of understanding how environmental factors can modify complex biological systems across scales; from direct molecular responses to intergenerational disease susceptibility
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Thrilled to share my postdoc work @hackettlab, the first to show intergenerational impact of gut microbiota via the gut-germline axis in mice: https://t.co/Ov6gvXvmDL My utmost gratitude @hackettlab being inspiring mentor, cosupervisor @BorkLab all my colleagues @EMBLRome @EIPOD3
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Great opportunities with exciting projects in my lab!
Job Postings – we have positions to fill ➡ Postdoc (m/f/d) – Bioinformatics – lab of @AsifaAkhtar1 (Deadline: May 13, 2024) https://t.co/nsCqSmMt1Y ➡ Postdoc (m/f/d) – Allelic Gene Regulation – in the lab of @AsifaAkhtar1 (Deadline: May 13, 2024) https://t.co/ne6qihVU7I (1/3)
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Job Alert 🚨 – Interested in mice, microbiome, and molecular biology? Then we have a great offer for you. The lab of @a_denboba is #hiring a »Technical Assistant«! Learn more about your future in our job ad: https://t.co/WfRCBATG0J
#TA #job #maxplanck #epigenetics
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