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John Lovell Profile
John Lovell

@_johntlovell

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Evolutionary biologist and outdoor enthusiast | comparative & quantitative genomics (mostly plants) | HudsonAlpha Genome Sequencing Center & Joint Genome Inst.

Joined February 2021
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@_johntlovell
John Lovell
2 months
Link to applications and details here:. Postdoctoral Research Associate - Plant Systems Biology & The Center for Bioenergy Innovation (CBI) Job Details | Oak Ridge National Laboratory.
jobs.ornl.gov
Postdoctoral Research Associate - Plant Systems Biology & The Center for Bioenergy Innovation (CBI)
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@_johntlovell
John Lovell
2 months
🚨 We're looking for a #postdoc to join our team at the Center for Bioenergy Innovation at Oak Ridge National Labs, TN 🚨. Project: Advance poplar bioenergy by understanding adaptive trait/genomic variation using breeding, pop gen, and bioinformatics. Apply by 18-Aug.
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@_johntlovell
John Lovell
4 months
Wow, the cover looks great! .Nice work Patrice and @roederlab.bsky.social. The GENESPACE plot uses our new @jgi Pennycress and Brassica rapa genomes built in collaboration with @SpicyBotrytis & @ktgreenham, hosted on @phytozome.
@RoederLab
Roeder lab
4 months
Check out the beautiful cover to our focus issue on Translational research from Arabidopsis to crop plants and beyond. More articles coming shortly. Congrats Patrice Salome and @_johntlovell
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@_johntlovell
John Lovell
7 months
Happy to see this out!! Check out my thread over at the better place for some quick background and summaries.
@biorxiv_genomic
bioRxiv Genomics
7 months
Improving American chestnut resistance to two invasive pathogens through genome-enabled breeding #biorxiv_genomic.
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@_johntlovell
John Lovell
10 months
RT @aeharkess: We are still looking for speakers for the PAG Plant Reproductive Genomics session - please reach out if interested!.
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@_johntlovell
John Lovell
11 months
RT @AdamRutherford: Ok, here we go: Much of my work concerns the history and return of scientific racism. I’ve written extensively about at….
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@_johntlovell
John Lovell
11 months
RT @carriewessi: Join us!! I'm recruiting a postdoc and grad student to work with us on parallel trait evolution, quant and pop gen, and sp….
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@_johntlovell
John Lovell
1 year
There are so many things to like about this paper — very cool data viz, nuanced treatment of complex plant #pangenomes, integrations with traits. I also appreciate a lack of the non-sensical term "super pan-genome" that is somehow now in vogue😉.
@Matt_Ben_
Matthias Benoit
1 year
🚨 Excited to share this #preprint from my postdoc in the Lippman lab @CSHL, in collab. with @mike_schatz & many others! Using pan-genomics & pan-genetics across the Solanum genus 🍅🥔🍆 we reveal gene duplications 🧬 as contingencies in crop engineering.
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@_johntlovell
John Lovell
1 year
Love this!!! This is why we are calling the assembly-only follow up “DEEPSPACE”.
@nptikhomirov
Nikita Tikhomirov
1 year
Every time with my favorite GENESPACE pipeline by @_johntlovell . (those who know can tell if the shooting stars here are allo or auto 😉)
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@_johntlovell
John Lovell
1 year
RT @njkooyers: Our preprint is up! Using a pop genomic dataset spanning 6 continents and 4 common gardens in the native & invasive range o….
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biorxiv.org
Rapid adaptation during invasion has historically been considered limited and unpredictable. We leverage whole-genome sequencing of >2600 plants across six continents to investigate the relative...
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@_johntlovell
John Lovell
1 year
I'm putting together an analysis of variation between genomes in model systems . what are the *two* most-used reference genomes for the following?.Human -- Hg38 / CHM13.Mouse -- GRCm39 / ?.Arabidopsis -- Araport11 / ?.Maize -- B73 / ?.Rice -- (?IRGSP1?) / ?.Soybean -- Wm82 / ?.
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@_johntlovell
John Lovell
1 year
RT @KodaniLab: The @KodaniLab is looking for a talented lab manager and senior scientist. Come join us @hudsonalpha and work alongside @nnu….
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@_johntlovell
John Lovell
1 year
All this work was led by @AdamHealey65, and made possible with funding and support from @hudsonalpha @jgi @BerkeleyLab @jbei. Find the genome on @phytozome
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@_johntlovell
John Lovell
1 year
We combined many data sources including @PacBio HiFi, HiC, @Illumina sequencing of single chromosome sorts, and optical & genetic maps. This produced a genome that presents the full set of biological sequence variation in the R570 hybrid cultivar.
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@_johntlovell
John Lovell
1 year
So, back to the original question - how can we make a sugarcane genome that is useful? To improve sugarcane, breeders look for genetic diversity within individuals; these are sites that segregate in selfed progeny populations — we need a genome that represents this diversity.
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@_johntlovell
John Lovell
1 year
However, in sugarcane this isn't appropriate: since gene copy number varies we cannot know the physical location of identical sequences. This means we cannot and should not produce a 'T2T' assembly for every all 120 chromosome in R570.
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@_johntlovell
John Lovell
1 year
In simpler genomes like auto-tetraploid potato, IDB blocks due to inbreeding can be computationally duplicated so that each biological haplotype has the full complement of sequence - a 'T2T' assembly.
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@_johntlovell
John Lovell
1 year
But, it gets more complex. As the pedigree above shows, there is lots of inbreeding in hybrid sugarcane (R570 has only three grandparents), and about half of domesticated haplotypes are identical by descent (IBD) within the last century.
@AdamHealey65
Adam Healey
1 year
It's finally published! The first polyploid reference genome for sugarcane cultivars. This is the most complex plant genome we have ever completed and a fantastic resource for sugarcane breeders and researchers! @hudsonalpha @jgi @BerkeleyLab @jbei.
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