Yulin Mo
@YulinMo_
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PhD candidate in @UofTIMS @ganglabstyle Researching nanomedicines for cancer therapy | Fan of lipid nanoparticles
Toronto, Ontario
Joined August 2019
✨New Doctor Alert!✨Last Friday, @YulinMo_ defended his PhD and had his thesis approved without corrections!
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Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles | Journal of the American Chemical Society @researchuoft @UofT @pmcancercentre
pubs.acs.org
Lipid nanoparticles (LNPs) are widely used for delivering therapeutic nucleic acids, yet the relationship between their internal structure and intracellular behavior, particularly before RNA release,...
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4/4: Finally, a heartfelt thank you to our incredible collaborators, Dr. Mohammad T. Mazhab-Jafari (@MMJ_cryoEM) and Dr. Sabrina Leslie (@SabrinaRLeslie)! This work would not have been possible without your invaluable support
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3/4: Employing Convex Lens-induced Confinement (CLiC) microscopy, we provided real-time visualization of how individual LNP dissociate and release their siRNA payloads upon exposure to light
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2/4: The internal organization of lipid-siRNA critically affects how LNP responds to external light stimuli, leading to different level of siRNA endosomal escape
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1/4: Using cryo-EM and various photochemical assays, we discovered: High siRNA payload ➡️ defined multilamellar structures; lower payloads ➡️ amorphous cores. Regardless of siRNA loading, they prefer to localize near LNP surface
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How exanctly does lipid-siRNA organization control the intracellular dynamics of LNPs? Our latest @J_A_C_S article provides insights on the link between LNP internal structure and its intracellular delivery profiles. 🧬 @gzheng74 @ganglabstyle
https://t.co/MfGiPCdGO0
pubs.acs.org
Lipid nanoparticles (LNPs) are widely used for delivering therapeutic nucleic acids, yet the relationship between their internal structure and intracellular behavior, particularly before RNA release,...
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Specifically, I want to thank @BioimagingNA for supporting my participation in the workshop. Truly it’s an exciting time to revolutionize nano drug delivery with super resolution techniques!
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Had an incredible week at the #MLMCSTED2024 Workshop! Huge thanks to @clairebrown514 and all the amazing imaging experts for organizing and teaching us EVERY aspect about STED. So happy to be part of this fantastic imaging community!! @McgillABIF @BioimagingNA #imagingthefuture
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Just out in @NatRevDrugDisc "60-year evolution of #LNP for nucleic acid delivery" by legends Pieter Cullis @UBC and Phil Felgner @UCIrvine
https://t.co/mwkLPYgf5u
nature.com
Nature Reviews Drug Discovery - Lipid nanoparticle-based systems are increasingly being utilized for the delivery of nucleic acid-based vaccines and therapeutics. In this Perspective, Cullis and...
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It’s amazing experience chatting with all the great scientists in the field! I really enjoyed and learned a lot in the LRD conference. Big thanks to Dr. @YvonnePerrie and the organizing committee!
🎉Congratulations to Zheng Lab member @YulinMo_ for winning a poster award at the 18th Liposome Research Days in Glasgow, Scotland! #LRD2024 🎉
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Excited to see this paper is finally out! We have shown that incorporating porphyrin-lipids into the clinically approved Onpattro formulation enables light-activated siRNA endosomal release (LASER). Big thanks to everyone on the paper!
Fresh new paper from the Zheng lab on @acsnano ! "Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles" https://t.co/iLOEQlt8vv Congrats @YulinMo_ and co-authors!
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Fresh new paper from the Zheng lab on @acsnano ! "Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles" https://t.co/iLOEQlt8vv Congrats @YulinMo_ and co-authors!
pubs.acs.org
Lipid nanoparticles (LNPs) have achieved clinical success in delivering small interfering RNAs (siRNAs) for targeted gene therapy. However, endosomal escape of siRNA into the cytosol remains a...
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Gangsters reunion at the @NMIN_NCE Scientific Meeting! 🎉Congrats @YulinMo_ and Michael Valic on your poster awards and @TiffanyHo_ on your NMIN ATC Silver Certification! 🔥
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Seven technologies set to shake up science in 2022
nature.com
Nature - Our fifth annual round-up of the tools that look set to shake up science this year.
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Very excited to share this @PNASNews paper on the mechanism of tissue-specific #mRNA delivery using SORT #LNPs . Here we provide evidence for an endogenous targeting mechanism. Congrats to Sean and Qiang! @UTSWNews @utswBMEprogram
https://t.co/nzCcsnrNuq
pnas.org
Lipid nanoparticles (LNPs) are a clinically mature technology for the delivery of genetic medicines but have limited therapeutic applications due t...
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