Daniel Siegwart
@DJSiegwart
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Siegwart Research Group | Department of Biochemistry | Simmons Cancer Center | Prof. Daniel J. Siegwart | UT Southwestern Medical Center | Posts are my own.
Dallas, TX
Joined September 2016
This #throwbackthursday, we are throwing it back to last Friday to celebrate Graduate Student Researcher Joshua Robinson in the @GDE_UTSW Lab, who successfully defended his dissertation. Congratulations, Dr. Robinson!
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Great visit last week to @DJSiegwart, Ph.D., research lab at @utswbme! His groundbreaking work on lipid nanoparticles for alpha-1 antitrypsin deficiency offers hope to thousands affected by this rare genetic condition. Learn more: https://t.co/c11eoYv4t3
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Congrats to our team on publishing in ACS Nano! We engineered LNPs to target kidney tumors via vitronectin binding, boosting mRNA delivery 952x in vitro and 42x in vivo. #CancerResearch #LNP #mRNA Read more:
pubs.acs.org
Although the delivery of genetic therapies to tumors using nanoparticles remains challenging, targeting may be enabled via plasma membrane receptors overexpressed on certain cancer cells. Here, we...
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Congrats to Yehui for winning the 2025 Ida M. Green Award at UT Southwestern! Her work offers new hope for cystic fibrosis patients. A true leader in science and the student community! #WomenInSTEM #GeneTherapy #LNP #UTSouthwestern Read more:
utsouthwestern.edu
Yehui Sun, a graduate student in the Siegwart Lab, has been honored with the 2025 Ida M. Green Award for research developing lipid nanoparticles that deliver molecular gene editing machinery to lung...
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Yehui Sun, PhD candidate in @GDE_UTSW Lab, was presented with the Ida M. Green Award on Friday, July 11 during a small reception. Congratulations to Yehui for her commitment to research excellence, the well-being of fellow students and community service!
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The Dallas Morning News recently featured @GDE_UTSW in Rescued by fat bubbles: UTSW scientists treat rare genetic disease with designer molecule. Read the article at the link below.
Rescued by fat bubbles: UTSW scientists treat rare genetic disease with designer molecule
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Rescued by fat bubbles: UTSW scientists treat rare genetic disease with designer molecule
dallasnews.com
In a paper published last month, researchers at UT Southwestern Medical Center introduced lipid nanoparticles — hollow, fatty spheres often 100,000 times...
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Last evening, we were proud to induct the newest class of NAI Fellows into the Academy. The highest professional distinction awarded solely to inventors, this distinction recognizes a lifetime of innovation, impact, and leadership in invention. These scholars have not only
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It was an honor to be inducted into the National Academy of Inventors (NAI) @AcadofInventors tonight!
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Congratulations to Dr. Minjeong Kim and all additional coauthors!
Our lab’s latest publication in @NatureBiotech led by Minjeong Kim and @DJSiegwart. Read the full story here:
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Our lab’s latest publication in @NatureBiotech led by Minjeong Kim and @DJSiegwart. Read the full story here:
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Amogh Vaidya, Graduate Student Researcher in the @GDE_UTSW Lab, successfully defended his dissertation "Development of Organ-specific Lipid Nanoparticles for Delivery of Nucleic Acid Therapeutics" on Friday, May 30. Congratulations, Dr. Vaidya!
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Science at #UTSW goes deep – down to the nucleic level. Research led by @DJSiegwart has unlocked synthetic lipid nanoparticles as delivery vehicles for genetic medicines. Explore more in the latest edition of #DiscoveryAtUTSW. https://t.co/ANCIQt64cK
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RBL LLC Announces Launch of Sentinel BioTherapeutics at the 2025 ASCO Annual Meeting
finance.yahoo.com
RBL LLC, a pioneering biotech venture creation studio dedicated to rapidly building companies based on breakthrough medical technologies from Rice University, today announced the launch of Sentinel...
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A must watch (and share) on the importance of science funding. Clear articulation of the massive return on investment back to society. @davidrliu @GDE_UTSW
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! https://t.co/cyVZpAwJiq
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Throwing it back today to celebrate @YehuiSun, @GDEatUTSW Graduate Student Researcher, for earning a scholarship award to attend @KeystoneSymp's Precision Genome Engineering meeting in March. Yehui gave a talk on the lab's most recent publication in Science. #ThrowbackThursday
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Principal Investigator Daniel Siegwart (@DJSiegwart) and researchers at @UTSWMedCenter report the chemical design, synthesis and optimization of high-density brush-shaped polymer lipids that reduce anti-PEG antibody binding to improve protein production consistency in repeated
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@C_Martins__ and @juan_avetrece just wrapped up a fantastic interview with @DJSiegwart for the upcoming @CRS_YSC & @DDTReMedia joint series. Insightful, inspiring — and just the beginning. Stay tuned for what’s coming! #NewBeginnings #YoungScientists @CRSScience
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Check out our work on brush-shaped polymer lipid as a potential replacement for clinically used DMG-PEG lipid for future mRNA therapeutics in @NatureMaterials led by @YufenXiao @DJSiegwart ⬇️
Lipid NPs containing brush-shaped polymer lipids as a replacement for commonly used PEGylated lipids enable the repeated administration of mRNA therapeutics without loss of performance in protein replacement therapy and genome editing models. @GDE_UTSW
https://t.co/jKURbNgEuF
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