Thomas Welte
@WelteThomas
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Clinician scientist @unispital_usz, @UZH_en, @SFB1453_NephGen @NCCR_RNADisease. RNA + dev. biology.
Joined August 2019
RT @MarcBhler4: Novel insights into the silencing of an understudied transposable element - check out our latest preprint by Jakob Schnabl-….
biorxiv.org
Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence...
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RT @NCCR_RNADisease: Welcome to @WelteThomas as a new Associate Member of the NCCR RNA & Disease! Clinician Scientist at University Hospita….
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RT @LabGrosshans: Excellent choice - congratulations, Victor and Gary, for this deserved recognition of your breakthrough work!.
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Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
pubmed.ncbi.nlm.nih.gov
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been extensively investigated in the past, the advent of...
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RT @GenesDev: A novel protein complex, ChAHP2, is involved in silencing of ERVs and LINE1 elements, complementing the SINE-targeting ChAHP….
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RT @NCCR_RNADisease: Preprint by @LabGrosshans (@FMIscience) & @ward_lab (@ucsc) w/ 1st authors Rebecca Spangler, @GuinevereAshley, @Kathri….
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RT @betowbin: Two more weeks to apply for #PhD position in #Quantitative #Developmental #Biology using #Celegans. Join us to study how grow….
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RT @LabGrosshans: What's better than publishing a paper? Publishing it next to another paper from your former postdoc's lab. Congratulation….
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RT @SchragaSchwartz: What are the forces shaping m6A evolution? Using interspecies hybrids in yeast and mammalian systems, we find that cha….
genomebiology.biomedcentral.com
Background N6-methyladenosine (m6A) is the most abundant mRNA modification, and controls mRNA stability. m6A distribution varies considerably between and within species. Yet, it is unclear to what...
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RT @LabGrosshans: Ever wondered how biological clocks time developmental events? @LabGrosshans @FMIscience we do - and use experiments and….
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Congratulations Luke!.
@mscienceaustnz is proud to once again sponsor the Mid-Career Awards at @GenomeConf. Congratulations to @LukeIsbel and @HaloomRafehi. Impressive research and excellent communication.
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RT @PetersLabFMI: @PetersLabFMI: Excited to share our latest preprint lead by Greg Fanourgakis (@Grigo_Fanou). Key findings are that DNA me….
biorxiv.org
DNA methylation (DNAme) serves a stable gene regulatory function in somatic cells ([1][1]). In the germ line and during early embryogenesis, however, DNAme undergoes global erasure and re-establish...
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RT @MarcBhler4: We’re thrilled to report the discovery of ChAHP2! Its chromatin binding specificity is distinct from ChAHP, predominantly a….
biorxiv.org
Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive...
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RT @ItaiYanai: Our paper is out today in @Nature! Imagine getting this plot when studying single-cell data of growing bacteria! Could it be….
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RT @betowbin: In our new paper in @NatureComms ( we show #robustness of pharynx-to-body #scaling to tissue-specifi….
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Massively parallel mapping of substrate cleavage sites defines dipeptidyl peptidase four subsite cooperativity
biorxiv.org
Substrate specificity determines protease functions in physiology and in clinical and biotechnological application. However, affordable and unbiased assays for large-scale quantification of substrate...
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Great collaboration by @SFB1453_NephGen scientists Frederic Arnold and @LukasWesterman4.#diabetes #KidneyWeek2023.
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How does sugar consumption affect renal health? Data from ~19k patients at @Uniklinik_Fr show the scary truth: Renal risk starts to increase already in the prediabetic range. Find out more in our newest publication in @JInternMed:
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