Grosshans Lab
@LabGrosshans
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Studying mechanisms of developmental clocks and timers
FMI Basel, Switzerland
Joined April 2021
Out now – our paper using temporally highly-resolved expression profiling and mathematical modeling to detect dynamic #miRNA expression in #C. elegans larvae and determine the mechanisms: https://t.co/aUO9MoBibw
@FMIScience 1/8
academic.oup.com
Abstract. Temporally and spatially controlled accumulation underlies the functions of microRNAs (miRNAs) in various developmental processes. In Caenorhabdi
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Born out of a project on RNA silencing and thus funded, in part, by the @NCCR_RNADisease - thank you 🙏!
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Now out in @MolSystBiol 👇 - predicting protease activity quantitatively from a one-shot experiment as a way to engineer substrate half-lives and characterize proteases. Tweetorial (from the preprint) here:
@LabGrosshans develop a quantitative model for protease cleavage specificity and cooperativity of protease sites ➡️ https://t.co/QeT8SEzkCy
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Join us in our Proteomics Platform. And if you'd like a peek at some of the fun stuff we are doing, take a look at our latest paper, combining proteomics and modelling to assess and predict quantitatively protease substrate specificity https://t.co/u1XgTu7KMV (more details later)
link.springer.com
Molecular Systems Biology - Substrate specificity determines protease functions in physiology and in clinical and biotechnological applications, yet quantitative cleavage information is often...
The Proteomics Platform at the FMI is seeking a skilled Proteomics Specialist who is passionate about cutting-edge technologies in multi-disciplinary projects. Apply by November 30, 2024 at https://t.co/OvBnCN4V31
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Very cool 👇
🔬✨ New insights into tissue regeneration! Our study uncovers a novel mechanochemical mechanism in Hydra, revealing how mechanical forces and Wnt signaling work together to create intricate tissue patterns. #Cnidarians #Hydra #Biology #Regeneration
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We are recruiting a postdoctoral fellow @DiazCuadrosLab! Please spread the word! Check out our lab website for more information: https://t.co/ZtGvGsJquM
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Deadlines are approaching for @KeystoneSymp #NonCodingRNA Biology: New Roles and Diversity, this January in Keystone! See scholarship, abstract and discount reg dates: https://t.co/nSQjFRWXkv
#KSncRNA25
keystonesymposia.org
Join us at the Keystone Symposia on Non-Coding RNA Biology: New Roles and Diversity, January 2025, in Keystone, with field leaders!
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We have a 4-year PhD position in our lab to study RNA splicing regulation in collaboration with @YiliangDing @biouea @alperakaylab @NorwichRNAClub #RNA #Celegans #PhDposition
biodtp.norwichresearchpark.ac.uk
AKAY_U25DTP
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Always a pleasure when alumni visit the lab, bringing back lots of fond memories. Thanks also for sharing the latest insights into miRNA decay, @mdlmata !
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Register now & submit abstracts (deadline Dec 8) for the #Swiss #RNA Workshop on January 24, 2025, starting at 09:15 @unibern. Short talks selected from abstracts. Registration free of charge. See the next tweet for sponsors. https://t.co/066l8WgQMr Please help spread the word!
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Nobel Laureate and HMS Professor Gary Ruvkun shared lighthearted tales about his start, a science revolution, and the power of worms.
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Super exciting opportunity in the lab of our new colleague Anupama - do apply 👇
Looking forward to hiring my first PhD student this cycle🤩. If you are interested in using live imaging to understand how metabolic states are integrated with cell behaviors and fates, please apply! DM me for more info.
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News Report of Swiss National Radio (@srfnews) on the #miRNA #NobelPrize featuring NCCR PIs Helge Grosshans (@LabGrosshans, @FMIscience) and Markus Stoffel (@ETH_DBIOL, @ETH_en): https://t.co/7l1M5pRoPY
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Could not agree more - without "bluesky" fundamental research, no translational research, no clinical/medical application.
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We’re looking for a postdoc with a strong background in AI, biophysics, modeling or related. Please forward to potential candidates and RT 🙏 More details below 👇
Postdoc Opportunity👉Join @Guillaume_Diss' group to study how the sequence of a protein determines its function! In this role, you'll leverage large datasets to train generative models to predict protein-protein interaction affinity from sequence. Apply at https://t.co/8N4x7jfECh
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Because developmental processes are no longer properly timed across tissues, the vulva is no longer properly attached in the mutant worms - with dramatic consequences.
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How timely - https://t.co/bZ6JE5FrXU: Ambros and Ruvkun discovered miRNAs by studying the developmental timing pathway on which this PhD project focuses - the video 👇shows the consequences of mutating the let-7 miRNA, https://t.co/Sg2nRoBTE3
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It couldn’t be a better day to apply for a PhD in the @LabGrosshans! Amazing environment and great mentor!
We will be hiring 👇 - apply if you are interested in understanding mechanisms of developmental timing using genomics, genetics, molecular biology, quantitative time lapse imaging, modelling, ...
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Excellent choice - congratulations, Victor and Gary, for this deserved recognition of your breakthrough work!
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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