Grosshans Lab
@LabGrosshans
Followers
413
Following
421
Media
38
Statuses
383
Studying mechanisms of developmental clocks and timers
FMI Basel, Switzerland
Joined April 2021
Out now – our paper using temporally highly-resolved expression profiling and mathematical modeling to detect dynamic #miRNA expression in #C. elegans larvae and determine the mechanisms: @FMIScience 1/8.
1
5
10
Born out of a project on RNA silencing and thus funded, in part, by the @NCCR_RNADisease - thank you 🙏!.
0
1
3
Now out in @MolSystBiol 👇 - predicting protease activity quantitatively from a one-shot experiment as a way to engineer substrate half-lives and characterize proteases. Tweetorial (from the preprint) here:
@LabGrosshans develop a quantitative model for protease cleavage specificity and cooperativity of protease sites ➡️
1
2
8
Join us in our Proteomics Platform. And if you'd like a peek at some of the fun stuff we are doing, take a look at our latest paper, combining proteomics and modelling to assess and predict quantitatively protease substrate specificity (more details later).
The Proteomics Platform at the FMI is seeking a skilled Proteomics Specialist who is passionate about cutting-edge technologies in multi-disciplinary projects. Apply by November 30, 2024 at
0
2
2
Very cool 👇.
🔬✨ New insights into tissue regeneration! Our study uncovers a novel mechanochemical mechanism in Hydra, revealing how mechanical forces and Wnt signaling work together to create intricate tissue patterns. #Cnidarians #Hydra #Biology #Regeneration
0
1
0
RT @MDiazCuadros: We are recruiting a postdoctoral fellow @DiazCuadrosLab! Please spread the word! Check out our lab website for more infor….
0
13
0
RT @LCochella: Deadlines are approaching for @KeystoneSymp #NonCodingRNA Biology: New Roles and Diversity, this January in Keystone! See sc….
0
11
0
RT @alperakay_: We have a 4-year PhD position in our lab to study RNA splicing regulation in collaboration with @YiliangDing @biouea @alper….
0
96
0
Always a pleasure when alumni visit the lab, bringing back lots of fond memories. Thanks also for sharing the latest insights into miRNA decay, @mdlmata !
0
1
12
RT @NCCR_RNADisease: Register now & submit abstracts (deadline Dec 8) for the #Swiss #RNA Workshop on January 24, 2025, starting at 09:15 @….
0
5
0
RT @harvardmed: Nobel Laureate and HMS Professor Gary Ruvkun shared lighthearted tales about his start, a science revolution, and the power….
0
18
0
Super exciting opportunity in the lab of our new colleague Anupama - do apply 👇.
Looking forward to hiring my first PhD student this cycle🤩. If you are interested in using live imaging to understand how metabolic states are integrated with cell behaviors and fates, please apply! DM me for more info.
0
0
1
RT @NCCR_RNADisease: News Report of Swiss National Radio (@srfnews) on the #miRNA #NobelPrize featuring NCCR PIs Helge Grosshans (@LabGro….
0
5
0
Could not agree more - without "bluesky" fundamental research, no translational research, no clinical/medical application.
0
0
0
RT @Guillaume_Diss: We’re looking for a postdoc with a strong background in AI, biophysics, modeling or related. Please forward to potent….
0
13
0
Because developmental processes are no longer properly timed across tissues, the vulva is no longer properly attached in the mutant worms - with dramatic consequences.
0
0
1
How timely - Ambros and Ruvkun discovered miRNAs by studying the developmental timing pathway on which this PhD project focuses - the video 👇shows the consequences of mutating the let-7 miRNA,
1
2
9
RT @azziChiA: It couldn’t be a better day to apply for a PhD in the @LabGrosshans! Amazing environment and great mentor!.
0
1
0
Excellent choice - congratulations, Victor and Gary, for this deserved recognition of your breakthrough work!.
BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
0
4
36
RT @NobelPrize: BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc….
0
12K
0