Marc Bühler
@MarcBhler4
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Research Group Leader at @FMIscience. Studies Gene Expression and rides mountain bikes. https://t.co/hzQzQWsmdN
Schweiz
Joined May 2017
Requirements for establishment and epigenetic stability of mammalian heterochromatin https://t.co/kqyoS189Fv
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We want you! Join the Department of Molecular and Cellular Biology @MoCel_Geneva at the University of Geneva @unige_en @UNIGEnews @sciences_UNIGE and become our new colleague! Assistant (tenure-track) Professor or Associate Professor! Please RT - thanks https://t.co/mQzmG00cxA
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📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @ISBSIB). Apply here: https://t.co/XzEVss5wOO
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We are hiring- outstanding environment where colleagues share and care.
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at https://t.co/zpnP1Y4ZQx
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Kudos to @JosipAhel and the entire team for this important contribution to our mechanistic understanding of chromatin repression by the ChAHP complex. 🧬👏
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In conclusion, we propose that ChAHP represents a functional module that enables sequence-specific targeting of chromatin remodeling activity to counteract the binding of other chromatin regulators.
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ADNP binding to chromatin is independent of CHD4, and CHD4’s ATP-dependent remodeling activity is not required for its recruitment to these sites. Instead, CHD4 functions to restrict the access of other TFs, such as CTCF, to ChAHP target sites.
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The prevailing view is that chromatin remodelers promote transcription factor (TF) binding by making chromatin more accessible. However, this paradigm is reversed in the case of the transcription factor ADNP and the chromatin remodeler CHD4 within the ChAHP complex.
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Novel insights into the silencing of an understudied transposable element - check out our latest preprint by Jakob Schnabl-Baumgartner and colleagues https://t.co/sQUYsJQjK1
biorxiv.org
Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence...
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🚨 Only a few more days to REGISTER for the TriRhena Gene Regulation Club #Freiburg. Whether you are new or an established researcher in the Basel-Freiburg-Strasbourg region, this is your meeting when working in transcription, chromatin & gene regulation! https://t.co/WLwLRc3XLw
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The next TriRhena Gene Regulation Club takes place at the MPI-IE #Freiburg. Save your seat & submit a talk. Strengthen your local network & collaborate with peers. 📅 16 Jun 2025 | 14:00 🎟️ Free entry, registration required ✍️ Register by 6 Jun https://t.co/WLwLRc3XLw
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🚨 Job alert: We're looking for a collaborator with experience in animal care & administrative work to support our Animal Facility team. Strong interest in animal welfare & research essential. Apply now at https://t.co/aAcHdG7DwO
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Now in @MolecularCell: researchers led by @MarcBhler4 shed light on how transcription factors control genes in fission yeast—plus, they created FMI TFexplorer, a free tool for scientists! @PomBase Read more about this work: https://t.co/drL1Tl9GzP
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SRF, the public 🇨🇭broadcaster, wants to make major cuts in science journalism, e.g. cancelling the excellent Wissenschaftmagazin, to which FMI has contributed in the past… Bad idea in a world increasingly filled with misinformation! Sign the petition👇 https://t.co/95gIixteot
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The next TriRhena Gene Regulation Club takes place at @IGBMC in #Strasbourg. Save your seat & submit a talk. Strengthen your local network & collaborate with peers. 📅 5 Feb. 2025 | 14:00 🎫Free entry, registration required ✍ Register by: 14. Jan. https://t.co/WLwLRc4vB4
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We have open PhD positions! Application is now open. Apply to our and other NKI groups via the NKI PhD program at
Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other @NKI_nl labs. https://t.co/ZyuJE43wsH
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Congratulations to FMI alumna Claudia Keller Valsecchi (@KellerValsecchi) on being awarded the prestigious Friedrich Miescher Award 2025, recognizing her outstanding achievements in biochemistry 🎉 https://t.co/BFtBUh50lD
biozentrum.unibas.ch
Dr. Claudia Keller Valsecchi who was recently appointed to the Biozentrum has been selected to receive the Friedrich Miescher Award 2025.
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📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: https://t.co/9VkmdAZqzP
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China clearly sees the potential of proteomics and is about to place a gigantic bet on it; multi-billion dollar and 30 years!!! All the better for the advancement of science and health. We contributed to the white paper out now in @Nature
https://t.co/480tmOJQ3C
nature.com
Nature - We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our...
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