Walid Khaled
@WTKLAB
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Professor @univcampharm and @SCICambridge. Fellow of @magdalenealumni. Ageing, Resilience and Cancer Prevention. @wtklab.bsky.social
Joined June 2014
I am pleased to share the final version of our Human Breast Cell Atlas with @MarioniLab now out @NatureGenet. There are important new additions, which I will leave to @Dr_SaraPensa and @AustinDReed to mention👇 . Couple of points i want to highlight 👇: https://t.co/tMCyMRJAdh
I am very pleased to share our second and largest contribution to “The Human Breast Cell Atlas” (HBCA) project. Buckle up a longish thread ahead! https://t.co/hEmnIJKNsr
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Thrilled our study on anti-progestin therapy for breast cancer prevention is out! A pleasure to be part of the team led by Bruno Simões, @RobClarkeLab + @DrSachaHowell, @MCRBreastCentre w @rmkhokha @WTKLAB. Team science moving us towards cancer prevention! https://t.co/gDsSLCunI9
nature.com
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
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PAPER OUT!! 🥳🥳🥳 Clinical potential of WGS data linked to mortality statistics in patients with breast cancer in England #shout out to #DaniellaBlack @GenomicsEngland And all the patients that shared samples across @NHS 1/n
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Could PARP inhibitors, targeted drugs already used to treat cancer, also help prevent it? We're part of a coalition of charities that believes the answer could be yes. And we're calling for urgent research to find out. https://t.co/NcyAYo2mtA
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Excited to share our new preprint introducing CenSegNet, a deep learning framework for high-throughput, spatially resolved, single-cell centrosome profiling in heterogeneous tissues. Co-led by brilliant PhD students, Jiaoqi Cheng & Keqiang Fan. 1/3 https://t.co/OVzDIsGFba
biorxiv.org
Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We...
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Congratulations to the team on all their hard work on developing this first of its kind model! @Dan_Lester8 @aventura71 @psalmotoxin @WTKLAB @ShelleyBuffens1 @KYTsaiLab @LabElsaFlores @CD_AACR
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Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l_cmurphy below. Check out the news feature https://t.co/r1bXqfpPSU and terrific editorial from Dennis Lo
science.org
The cells could be a new source of tumor DNA for liquid biopsies
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @ScienceMagazine! 🎉 🧽 📖 Read our paper here: https://t.co/CvYSNq2nHj 🎬 Watch a summary: https://t.co/qvuZR3reTj 🧵 Or keep reading for the key points! 🔑 1/19
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We are recruiting….Any clinician interested in doing a PhD in London on lymphoma and mechanisms of transformation/ TME….please apply (and get in touch with us)
Are you a #clinician in training? Do you want to do a #PhD in #cancerresearch? 🧪🔬🦠🧫Recruitment for the September 2026 start is open now!👨🏾🔬👩🔬 Check out our webiste for more information and potential supervisors. https://t.co/BLdHfk3mQD
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(1/12) Over a year ago, we launched a new project to explore whether the tissue microenvironment could predict cellular behaviour and whether reprogramming might unlock new therapeutic avenues. 🧬 Spatial transcriptomics provides deep insights into tissue organisation. We
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Today saw our final year PhD students and MPhil students give talks on their research, whilst 2nd years presented posters of their progress so far 😀 A great day showing the diversity of research in the Department - congratulations to poster and talk prize winners!
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We’re thrilled to share our latest publication in @Cancer_Cell, and very proud of C. Rozalén for this tour de force uncovering how TIM3⁺ breast cancer cells drive immune evasion during micrometastasis. #CancerImmunology #BreastCancer #Metastasis
cell.com
Rozalén et al. report that TIM3 in breast cancer drives a specific mechanism of immune escape during micrometastasis. TIM3+ tumor cells exhibit stemness/EMT features and promote immune-evasion by...
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Not long left to apply! Join us at the Stem cells and Cancer conference in Malta. Deadline 31st July!
🚨Programme Live! Our Stem Cells & Cancer Conference Programme is shaping up nicely, with final touches being made to the programme. This is now available to view on our website, don't miss out on joining @JonesLabUCSF @PlathLab @MariaPAlcolea & @KateMiro1 in Malta this
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Could this be the future of cancer prevention? Walid Khaled @Cambridge_Uni, a new ERC Advanced Grant recipient, will work on a preventive vaccine for breast cancer. 👉 https://t.co/HbsTkUTx4W
#ERCAdG #CancerResearch #FrontierResearch
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How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing https://t.co/OY9T4rHYrj & predict plasticity w. snRNA/ATAC+deep learning https://t.co/AwlOHu3cq6 🧵
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We're recruiting a teaching associate to work across Biochemistry and Pharmacology! 🔬 The role focuses primarily on the delivery of teaching and examining but will also be involved in course development. Please apply here: https://t.co/sZQFvChZYY
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A huge thank you to all patients, all the NHS hospital trusts, and trials teams that took part in the PARTNER trial @CUH_NHS; @CRUKCamBreast; @CRUKCamCentre; @Cambridge_Uni; @CambridgeBRC Thanks to @NatureComms and their editorial team!
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Congrats to all the team. Important findings and hopefully will change practice.
🔊Results from the PARTNER Trial hereditary BRCA #breastcancer cohort results have just been published in @NatureComms: https://t.co/lMHPRtsmir. A great read alongside the #TNBC result: https://t.co/LFTv80C16F. Thanks to all the patients that took part.
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Our Assistant/Associate Professor role closes in just a few days! See below to apply 🎓
New job posted! We are recruiting for a Research Assistant/Associate (Fixed Term) Find out more and apply here: https://t.co/ieDUp3rtJF
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Thanks to the team and collaborators @JCarrollLab, @LauraItzhaki @RahmanLab and funder @CRUKresearch @BreastCancerNow @UnivCamPharm @SCICambridge
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We identify some chemical fragments that could disrupt the interaction BUT more work is needed to make them into potent drugs - I am open to discussions with industry and academic partners to make this happen.
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If you are expecting UMAPs, you will be disappointed!! We found a TNBC specific protein-protein interaction between BCL11A and CHD8. We show that disrupting this interaction has the potential to specifically target TNBC without disrupting the other critical roles of BCL11A.
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