CBDD (Chemical Biology & Drug Discovery)
@UU_Glycoscience
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Synthesis, chemical glycobiology, MedChem, host-microbe interaction, germinal center, RNA, post-translational modification… https://t.co/3rZU3TQP1K
Utrecht, The Netherlands
Joined June 2018
“I’m thrilled to receive an ERC-CoG 2025. This reflects the collective effort of many brilliant mentors, collaborators, students, and colleagues — thank you for shaping this journey. Douze points from Brussels!” #glycotime @UU_Glycoscience
erc.europa.eu
The European Research Council (ERC) has selected 349 mid-career researchers to receive this year's Consolidator Grants. With funding from the EU’s Horizon Europe programme, these grants will support...
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Tremendous help from @RobertPdeVries1 lab and @LiangRuonan with the red blood cell related work.
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New @angew_chem paper jointly supervised by @zeshi_li and @TheBoonsGroup describes the chemoenzymatic synthesis of all O-acetylated forms of GD3 as intact glycolipids, and the use thereof to study virus binding in cellular context. https://t.co/pI1jtJBewY
onlinelibrary.wiley.com
7-O-, 9-O-, and 7,9-di-O-acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α-glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed...
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Super excited that our division is part of this great scheme! #glycotime @UU_Glycoscience @TheBoonsGroup @zeshi_li
uu.nl
A better understanding of protein glycosylation offers insights into disease mechanisms and helps improve therapeutic medicines.
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Congratulations to CBDD researchers, Geert-Jan Boons and @zeshi_li and members of #BioBeyond_NL, a consortium co-led by Maastricht, Utrecht, Radboud University and LUMC researchers to advance (glyco)proteomics, glycomics and spatial omics. Read more👇 https://t.co/Y5hhcFrD4t
uu.nl
A better understanding of protein glycosylation offers insights into disease mechanisms and helps improve therapeutic medicines.
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New @J_A_C_S paper from @TheBoonsGroup, spearheaded by Mehman @mehmanbunyadov describes the chemoenzymatic synthesis of intact HNK-1 glycolipids, which were used to glycoengineer erythrocyte surface for binding and lysis assays. https://t.co/aKytxyvez6
pubs.acs.org
Several neuropathies, such as Guillain–Barré syndrome and myelin-associated glycoprotein neuropathy (MAG), are caused by antibodies targeting glycosphingolipids. Several studies have indicated that...
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Excited to have this story out on bioRxv! #glycotime #lovevirology #H5N1 The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans.
biorxiv.org
Highly pathogenic H5Nx influenza A viruses are causing unprecedented, season-independent outbreaks across avian and mammalian species, including dairy cattle, a novel reservoir. The sialoside-binding...
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Congratulations to the research team on their recent publication in Nature, titled "Receptor-binding specificity of a bovine influenza A virus" 💯🦠🐮 #InfluenzaResearch #CollaborativeScience @tompkins_lab @ugavetmed @UGAResearch
https://t.co/QNFbqN4oXl
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Excited to share an update on heparan sulfate (HS)-associated cell-surface RNA (hepRNA): https://t.co/I0O8yi9t9U
biorxiv.org
Recent discoveries have shown the presence of RNA molecules on the cell surface, defying the traditional view that RNA only functions intracellularly. However, it is not well understood how cell-su...
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Another heads-up for the #glycoRNA community from Uni Marburg👇There are many glycoproteins co-isolated with RNA by TRIzol method. They persist throughout RNA sample processing and are not easily degraded by proteinase K. Careful what you are looking at in an RNA blot!
Proteins are a source of glycans found in preparations of glycoRNA https://t.co/8eUZkGaU0j
#biorxiv_molbio
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Yes, viruses like it sweet! @UUUIPS CBDD researchers @TheBoonsGroup and @RobertPdeVries1, together with researchers in Erasmus Rotterdam, were awarded an #ENW-XL from the Dutch Research Council (NWO). It’s #glycotime for virology! #glycovirology
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I'm super excited that our consortium has been funded by the NWO! Can't wait to get started! @DebbyvanRiel @miranda_graaf @bart_haagmans @LisaBauerVirus @TheBoonsGroup @UU_Glycoscience @UUUIPS #glycotime
https://t.co/JRjZ3pHzx2
nwo.nl
21 research consortia have the chance to reach a breakthrough thanks to funding from the Open Competition Domain Science - XL. From fundamental research on the effects of certain materials on the...
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New @J_A_C_S paper from @TheBoonsGroup demonstrating peptidoligase-mediated, site-specific introduction of N-glycans into native proteins such as insulin, IL18 and IFNalpha-2a. This project was led by former post-doc Ana Gimeno.
pubs.acs.org
Glycosylation is an attractive approach to enhance biological properties of pharmaceutical proteins; however, the precise installation of glycans for structure–function studies remains challenging....
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Another week another editors’ pick, now out in ACS Infectious Diseases. HKU is quite promiscuous for glycan cores snd only really cares for 9-0-acetylated sialic acids
pubs.acs.org
Coronaviruses (CoVs) recognize a wide array of protein and glycan receptors by using the S1 subunit of the spike (S) glycoprotein. The S1 subunit contains two functional domains: the N-terminal...
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HKU1 - TMPRSS2 done ☑️! Now time for OC43!
The new issue is out! 👉 https://t.co/kgvR58Ln4z This issue features a high resolution structural analysis of the Prototype Foamy Virus, a pan-cancer proteogenomics study that expands the landscape of therapeutic targets and the recognition of the TMPRSS2 host receptor by
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#glycotime #H5N1 Receptor Binding Specificity of a Bovine A(H5N1) Influenza Virus
biorxiv.org
Outbreaks in the US of highly pathogenic avian influenza virus (H5N1) in dairy cows have been occurring for months creating new possibilities for direct contact between the virus and humans. Eisfeld...
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Check out our latest publication by Chun-Wei Chang (@rggOcdppppFsepC ) In this study, we elucidate the structure of glycosyl cations using cryogenic infrared ion spectroscopy and computational methods. 👉 https://t.co/Uv44rPxRpg
nature.com
Nature Synthesis - The role of cationic intermediates in the benzylidene-directed synthesis of 1,2-cis glycosidic linkages is unclear. Now cryogenic infrared spectroscopy provides insight into the...
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Two independent studies on Heparan sulfates’ role of presenting RNA and RBP on cell surface. One is from our CBDD researcher @zeshi_li 👇🏻
It’s heparan sulfate again?! In my post-doc research at @ChirlminJoo_Lab , we demonstrate heparan sulfate acts as scaffold to present RNA and RBP on cell surface. The three biomolecules work together to modulate cell-surface receptor-ligand interaction. https://t.co/OZbEu7HTN6
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