Utrecht Institute for Pharmaceutical Sciences
@UUUIPS
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Utrecht Institute for Pharmaceutical Sciences; Faculty of Science; Utrecht University; the Netherlands.
Utrecht, The Netherlands
Joined January 2022
Receptor-mediated transcytosis of nanobodies targeting the heparin-binding EGF-like growth factor in human blood-brain barrier models/ | Massimiliano Caiazzo @UUUIPS | @CRSBeNeLuxFr [Open Access] #nanobody #transcytosis #BloodBrainBarrier
https://t.co/InO7OWLnf3
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Save the date! June 27th is our 3rd GlycoScienceNL symposium...Geertekerk Utrecht! major #glycotime! @UU_Glycoscience @UUUIPS
https://t.co/DTkPWgOmQ4 Please tag and RT at will!
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I'm super excited that our consortium has been funded by the NWO! Can't wait to get started! @DebbyvanRiel @miranda_graaf @bart_haagmans @LisaBauerVirus @TheBoonsGroup @UU_Glycoscience @UUUIPS #glycotime
https://t.co/JRjZ3pHzx2
nwo.nl
21 research consortia have the chance to reach a breakthrough thanks to funding from the Open Competition Domain Science - XL. From fundamental research on the effects of certain materials on the...
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New Editors' Choice article in #ACSInfectiousDiseases 🏅 📑 The HCoV-HKU1 N-Terminal Domain Binds a Wide Range of 9-O-Acetylated Sialic Acids Presented on Different Glycan Cores 🖊 Ilhan Tomris et al @UUUIPS Read for free ➡ https://t.co/WYgdlIHaBY
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Another week another editors’ pick, now out in ACS Infectious Diseases. HKU is quite promiscuous for glycan cores snd only really cares for 9-0-acetylated sialic acids
pubs.acs.org
Coronaviruses (CoVs) recognize a wide array of protein and glycan receptors by using the S1 subunit of the spike (S) glycoprotein. The S1 subunit contains two functional domains: the N-terminal...
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Last Friday @mfalandt joined @UniStemDay @UniUtrecht to share our lab's work @ERC_Research #Volumebio and his research experience! So nice to see all the curiosity and interest from the high school students present #STEMeducation #Unistemday2024 thanks @UUUIPS for organizing
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Another chapter of Yunfei published. We got some real chemoenzymatic synthesis of kerstan sulfates for you https://t.co/2Tf1xw7jPS
@TheBoonsGroup @UU_Glycoscience @UUUIPS
pubs.acs.org
Keratan sulfate (KS) is a proteoglycan that is widely expressed in the extracellular matrix of various tissue types, where it performs multiple biological functions. KS is the least understood...
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The 2024 Advanced Functional Polymers for Medicine Conference will take place at @UUUIPS, June 5-7! Discover the latest developments in polymer-based systems for drug delivery, regenerative medicine & diagnostics. Info & registration (limited spots!): https://t.co/6P4yVDIW4e
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Many new cancer drugs in the EU lack clear proof of added benefit. But still nearly all those drugs manage to recover their substantial research and development (R&D) costs relatively quickly after approval. @UUUIPS #healthcare #costs
https://t.co/Ku1NRed66w
uu.nl
Many cancer drugs recently approved by the European Medicines Agency (EMA) lack clear proof of added benefit. This is particularly the case for drugs that are granted via special processes, intended...
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Very relevant articles: Many new oncology drugs approved in the EU lack proof of added benefit
uu.nl
Many cancer drugs recently approved by the European Medicines Agency (EMA) lack clear proof of added benefit. This is particularly the case for drugs that are granted via special processes, intended...
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Assymetry for the win! 10+ years of N-glycan synthesis and here we demonstrate that human influenza A viruses preferentially bind to the the a3 arm! #glycotime
https://t.co/dsq298xIlD
pubs.acs.org
Glycan binding properties of respiratory viruses have been difficult to probe due to a lack of biologically relevant glycans for binding studies. Here, a stop-and-go chemoenzymatic methodology is...
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Interested in the fascinating field of microproteins? Join my group in a collaboration with @s_heesch at the PMC. PostDocs apply below: https://t.co/G52z1I7HR0
@hecklab @prinsesmaximac
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Analytical #glycotime! If you are interested in analyzing O-acetylated sialoside-containing glycoproteins with precision, differentiating all O-Ac positional isomers, take a look at this one from @TheBoonsGroup. https://t.co/iOjt9tAbqC
@UUUIPS @UUBeta
nature.com
Nature Communications - O-acetylation is a common modification of sialic acids. Here, a library of synthetic O-acetylated sialosides made it possible to develop an ion mobility mass spectrometry...
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Now published in JACS Au! 6-O-sulfotransferase specificities! Great work by Yunfei @UUBeta @UUUIPS @UU_Glycoscience
https://t.co/kk9XbbgQ13
pubs.acs.org
Keratan sulfate (KS) is a glycosaminoglycan that is widely expressed in the extracellular matrix of various tissue types, where it is involved in many biological processes. Herein, we describe a...
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@mehmanbunyadov of @TheBoonsGroup developed a strategy for making HNK glycans. Backbone were prepared using enzymes, then chemical modifications. This is a reversal from what’s normally done in chemoenzymatic glycan assembly. You wanna coin a new term, Mehman? @UUUIPS @UUBeta
Now online: Article by @mehmanbunyadov, Geert-Jan Boons & co-workers @TheBoonsGroup @UU_Glycoscience Chemoenzymatic synthesis of human natural killer-1-containing glycans and application as serum antibodies probes https://t.co/CU6PdVrUGp ($)
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Congratulations to new UIPS PI's Kelly Stecker and @BvRavensteijn for receiving prestigious grants https://t.co/3JYPNubCSj
@UUPharmaceutics @hecklab
uu.nl
Two new PI's of UIPS have recently been successful in obtaining prestigious grants
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Success for chemical biology researchers. Two PIs from UIPS have received NWO Impulse funding.
uu.nl
Just before the summer a VENI and a VIDI grant landed in the same group.
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https://t.co/JU1A5t2MMf An excellent systematic review on ‘Animal Models for Studying Protein-Bound Uremic Toxin Removal’! In which Prof Masereeuw and @SilviaMMihaila from our consortium partners @UUUIPS were involved in 🔬#ckd #strategyckd #kidney
mdpi.com
Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to...
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Synthetic Heparanase Inhibitors Can Prevent Herpes Simplex Viral Spread (Geert-Jan Boons and co-workers) #glycotime #openaccess @TheBoonsGroup @UUUIPS @UICnews @uicovs @universityofga
onlinelibrary.wiley.com
A range of heparan sulfate (HS) oligossacharides was synthesized by a modular synthetic approach and evaluated as human heparanase (Hpse) inhibitors. Treatment of herpes simplex-1 virus (HSV-1)...
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