Bart Haagmans 🦠🐪 🤧
@bart_haagmans
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virologist, Erasmus Medical Center Rotterdam
Joined June 2015
Very proud of our new paper that demonstrates the importance of respiratory transmembrane mucins in defense against SARS-CoV-2. A true collaborate effort with @bart_haagmans and @UtrechtVirology that started in the first lockdown of the corona pandemic. https://t.co/4Zia6d1LIy
journals.plos.org
Author summary SARS-CoV-2, the virus that has caused the devastating COVID-19 pandemic, causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress...
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Our recent study to further characterization a MVA-MERS vaccine candidate: Monkeypox Virus Cross-Neutralizing Antibodies in Clinical Trial Subjects Vaccinated with Modified Vaccinia Virus Ankara Encoding MERS-Coronavirus Spike Protein
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My first paper is out! We identified the intestines of Nathusius's Pipistrelle Bats as a replication site of a naturally occuring Betacoronavirus to contribute to our knowledge on interactions of bat coronaviruses in their natural hosts. https://t.co/ejxEtHN6rz
journals.asm.org
Virtually all mammal species circulate coronaviruses. Most of these viruses will infect one host species; however, coronaviruses are known to include species that can infect multiple hosts, for...
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The HERA laboratory network, called DURABLE, kick off is now 🥳 Coming together in Paris with the common goal of advancing health security. DURABLE will provide rapid, high-quality scientific information to support 🇪🇺 preparedness & response to cross-border health threats.
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We made some interesting observations on the Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain https://t.co/NLeMy4rRdk
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Our latest research is now online @FrontImmunol! @du_wenjuan et al made a hexavalent biparatopic HCAb targeting the SARS-CoV-2 spike. This molecule neutralised multiple VOCs, whereas the parental HCAbs lost potency. Congrats to everyone involved! https://t.co/zyuEQdEs3J
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Mapping XBB.1's antigenic distance (among others): "We observed that human post-vaccination neutralisation titres reflected the antigenic map, as the largest reduction in neutralising titres compared with the D614G variant" https://t.co/epa5txNqqw
@LancetMicrobe
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Historic #smallpox vaccination and #monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but these responses are of lower magnitude after vaccination with MVA-BN, the #vaccine in use for protection against MPXV and smallpox @Corine_GvK
https://t.co/hTLaYmKJqg
nature.com
Nature Medicine - Historic smallpox vaccination and monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but MPXV-neutralizing antibodies are less frequent and of lower magnitude...
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This study is the result of another team effort between well prepared clinicians, virologists, public health specialists and others, honoured to work with all of them! @rorydevries @LucaMZaeck @MarionKoopmans @bart_haagmans @NatureMedicine @BayAreaBioEd @ErasmusMC
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First observations on vaccinia and monkeypox specific responses in person with infection and vaccination, with and without historic smallpox vaccination https://t.co/iLJVMhVSXF great teamwork again @rorydevries @Corine_GvK @bart_haagmans @GGD_RR @MartLamers
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Our new paper is out now! Persistence of MERS-CoV spike specific B cells and antibody responses induced by the MERS vaccine candidate MVA-MERS-S. Great work by @LeoMarWes and thanks for the great collaboration @SBeckerLab @bart_haagmans
cell.com
Weskamm et al. longitudinally describe B and T cell responses as well as antibody subclasses and neutralization capacity induced by three homologous immunizations with the MVA-MERS-S vaccine candid...
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New preprint: Pulmonary lesions following inoculation with Omicron in hamsters. Great work from Melanie Rissmann with help from @bart_haagmans @rorydevries @DebbyvanRiel @thijskuiken @MarionKoopmans and many others.
biorxiv.org
The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune-escape and increased viral spread. It remains unclear...
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A new Report finds that #Omicron BA1 and BA2 subvariants are antigenically distinct, offering insight into the #SARSCoV2 Spike antigen’s evolution and future vaccine development. ➡️ https://t.co/nzovZyrCMi
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Our 87G7 manuscript is now online @SciImmunology! 🎉 https://t.co/24NZX6KRnJ Thank you (and congrats) to the entire @MancoProject team! @du_wenjuan, @DanielHurdiss, @IevaDrulyte, @bart_haagmans, @LEnjuanes, @ncohnl, @H2020Projects, @dfg_public, @SURF_onderzoek @UniUtrecht
science.org
A broadly protective SARS-CoV-2–neutralizing monoclonal antibody targets a conserved epitope in the S protein receptor binding site.
We've been hunting for broadly reactive monoclonals to treat COVID-19. In our recent @biorxivpreprint, we describe an antibody capable of neutralising all known variants of concern to date! Great work from @du_wenjuan et al. https://t.co/vgy0sdL1hb
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Alright, the SAVE (SARS-CoV-2 Assessment of Viral Evolution program) paper is out! "Defining the risk of SARS-CoV-2 variants on immune protection" https://t.co/xGDthIHMnE
nature.com
Nature - The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and...
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SARS-CoV-2 pathogenesis https://t.co/ps93816wuJ
@bart_haagmans and @MartLamers explore recent clinical and experimental advances in understanding SARS-CoV-2 pathogenesis, interactions with host cells and the involvement of the immune system in the development of severe disease.
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In our recent review in Nat Rev Micr ( https://t.co/8yHRgbpxF8), we explore recent advances regarding SARS-CoV-2 pathophysiology, specifically focusing on new insights obtained using technologies such as single-cell omics, organoid infection models and CRISPR screens. @MartLamers
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Spreading of SARS-CoV-2 from hamsters to humans https://t.co/Mb3dQaYREk our comment on
thelancet.com
During the past 2 years, SARS-CoV-2 has spread globally through human-to-human transmission causing a devastating pandemic. Since its emergence, SARS-CoV-2 has displayed considerable host plasticity,...
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