🏃🏼 by 💧 Any recent 🚶🏻‍♀️🏃🏽‍♀️🚴🏼 photos from my oncology friends around the 🌍 ? @VedangMurthy @aadel_chaudhuri @cwspeers @andreasroder1 @HenningWillers @brookmans76 @_ShankarSiva @ResearchWyatt @ProfAJChalmers @shiv_smith @scserendipity1 @SimonMDLord @RenuEapen @AlisonBirtle

Artwork by @JeffKoons On display @UCSDHealth courtesy of Irwin and Joan Jacobs

@EricTopol @NEJM Very substantial reduction in mortality despite screening too late, too high a threshold, nonattendance in intervention arm, contamination in control arm, diagnosing too much low-grade dz, marginal dx/tx quality, and other issues. & NND 12 compares well to anything in prevention!

Went out to do an easy couple of miles but felt really strong so gave it a blast and that’s the fastest 2 miles since the knee replacement!

I think this supplemental figure from ERSPC prostate screening study is interesting with the mortality benefit still dominated by two countries. @pash22

@EricTopol @NEJM Each one of those deaths is me or a man like me whose families have been ripped apart by losing a Father, a Brother, a Husband, a Grandad. That’s the ultimate of harms!

📣 We’ve successfully randomised 1,645 patients to IP7-PACIFIC! RCT1️⃣ bpMRI vs mpMRI RCT2️⃣ image-fusion vs visual estimation targeting Top recruiters in October 🏆 1st – Imperial 🥈 Joint 2nd – Cumberland & St Peter’s Top total recruiters 🏆 Imperial - 346 🥈 Southend - 338

🚨23 years of PSA screening in @NEJM 🚨 👉ERSPC RCT of >162k patients 📅Median 23 year f/u PSA screening lead to... 📉 #prostatecancer mortality by 13% ✅1 death prevented for every 456 men invited for screening or 12 diagnosed w/ PCa 📉Risk of advanced PCa by 34% ⭐️Benefit

At 23 years of follow-up, population-based PSA screening of asymptomatic men led to a sustained reduction in prostate cancer mortality, although overdiagnosis remains a concern. Full ERSPC study results: https://t.co/DTw9NcUFJM Editorial: Early Detection of Prostate Cancer —

Exciting 23 year update from the ERSPC #prostatecancer screening trial from @MoniqueRoobol and team, and a great editorial @VickersBiostats. NND is down to 12 and still falling! And the benefit:harm ratio would be even better w/ modern screening/dx/tx pathways.

@TylerSbrt @DrSpratticus @dr_coops @NikiSushentsev @TonyFelefly @GhiamAlireza @alison_tree @OncoAlert @urotoday @PCF_Science @JAMAOnc @Uroweb @AmerUrological @wandering_gu @seanmmcbride @LoebStacy @LondonProstate1 @declangmurphy @CZamboglou @APCCC_Lugano @UroOnc @sophia_kamran There may be a way to capture some of that complexity in how we measure and report what is appreciable on imaging and biopsy. Thanks again for sharing this important information!

@TylerSbrt @DrSpratticus @dr_coops @NikiSushentsev @TonyFelefly @GhiamAlireza @alison_tree @OncoAlert @urotoday @PCF_Science @JAMAOnc @Uroweb @AmerUrological @wandering_gu @seanmmcbride @LoebStacy @LondonProstate1 @declangmurphy @CZamboglou @APCCC_Lugano @UroOnc @sophia_kamran I agree, it's complicated. The importance of cribriform histology is very important, visible on H&E and doesn't require molecular testing. Yet different foci may be competing molecular diseases of differering metastatic potential

@TylerSbrt @aadel_chaudhuri @cwspeers @andreasroder1 @brookmans76 @_ShankarSiva @ResearchWyatt @shiv_smith @scserendipity1 @SimonMDLord @RenuEapen @AlisonBirtle @mrsprostate @alison_tree @MariamAboian @sophia_kamran @lauren_henke @HimanshuNagarMD @JuanMiguelPechL @ethansgrumps @swoo_rad @Prof_Nick_James Great Ocean Road, VIC🇦🇺

Big News from #APCCC26 🚨 APCCC is opening a Call for Abstracts! Full details & submission 👉 https://t.co/U46NMslfll Creating new opportunities for younger investigators & the next generation of leaders in advanced #ProstateCancer @Silke_Gillessen & @AOmlin @fabioturco92

@lauren_henke @TylerSbrt @HimanshuNagarMD @aadel_chaudhuri @cwspeers @andreasroder1 @brookmans76 @_ShankarSiva @ResearchWyatt @shiv_smith @scserendipity1 @RenuEapen @AlisonBirtle @mrsprostate @alison_tree @MariamAboian @sophia_kamran @JuanMiguelPechL @ethansgrumps @swoo_rad @Prof_Nick_James @berlinmarathonE Sunset walkies w the 🐕

@TylerSbrt @HimanshuNagarMD @aadel_chaudhuri @cwspeers @andreasroder1 @brookmans76 @_ShankarSiva @ResearchWyatt @shiv_smith @scserendipity1 @SimonMDLord @RenuEapen @AlisonBirtle @mrsprostate @alison_tree @MariamAboian @sophia_kamran @JuanMiguelPechL @ethansgrumps @swoo_rad @Prof_Nick_James @berlinmarathonE Gorgeous! Here’s my sunrise run a few days ago!

@TylerSbrt @HimanshuNagarMD @aadel_chaudhuri @cwspeers @andreasroder1 @_ShankarSiva @ResearchWyatt @shiv_smith @scserendipity1 @SimonMDLord @RenuEapen @AlisonBirtle @mrsprostate @alison_tree @MariamAboian @sophia_kamran @lauren_henke @JuanMiguelPechL @ethansgrumps @swoo_rad @Prof_Nick_James @berlinmarathonE Great sunset, love it! Finally also beautiful autumn weather again in #Bavaria after 2 weeks of rain and storm - just coming back from a short cycling morning tour 🍁🍂☀️

Everyone in the lab loved having @carlosmacarrop visit!! Outstanding student from innovative @VHIO These international visits strengthen collaborations and spur us in new directions @RaqPerezLopez @quimmateo @PCF_Science community at its best! @UCSDCancer @UCSDRadMed

Wrapping up three amazing months in California at @TylerSbrt lab @UCSDHealth! Heading back full of new ideas and energy to keep advancing prostate cancer management. The perfect finale: attending the #PCFretreat25 - inspiring science and great collaborations ahead!! @VHIO

Balance is needed “a very complicated topic is being made unnecessarily simple” “men who had an unnecessary biopsy, or those not insubstantial men who were treated with significant side effects from surgery and radiotherapy and now regret their decision, must not be overlooked”

@LondonProstate1 NPCA says only 7% of men with low grade cancers had radical treatment. That suggests few men harmed. It also said men with aggressive cancers were being under treated. Agree that balance is necessary but the harm of late diagnosis is horrendous and far too often overlooked.