We have not gone far enough in harm reduction once treatment is given
Still too many biopsies, not enough active surveillance, too much conversion of AS to radical, too many having radical therapy with significant side effects & not enough focal therapy
#ipmasterclass24
@ethansgrumps
@philipdrinkwat6
@IP_London
Haha! Thanks,
@ethansgrumps
. I love the passion which is super important. There is nothing I want more than finding out how to find aggressive cancers early. On that journey, we just have to keep talking about the problems associated with screening of a healthy population.
Congratulations to Rakesh Heer for promotion to Professor of Urology at Newcastle!
He made no fanfare so I wanted to make a bit of noise for him.
He also Chairs NCRI’s Prostate Research Localised Subgroup.
@Heer_Lab
@NCRI_partners
@NewcastleHosps
@UniofNewcastle
I spent so much time 3-4 years ago writing this out every day several times a day, that it made sense to create this.
Did one for prostate cancer treatment options too.
Patients and relatives immediately saw their value.
@imperialurology
@IP_London
Thank you
@soph_cash
for referencing our decision aid. A real menu of BPH options available to men. Clear and concise information & adequate time for patients to digest the information is key
#bph
On this day, 14 years ago, Mark Emberton & I treated the very first patient with prostate cancer with focal HIFU.
Immensely grateful to all 20 prostate cancer patients for trusting us to join the first focal trial.
⭐️ The EAU guidelines on focal HIFU and focal cryotherapy have changed ⭐️
For advice on eligibility criteria & how patients can access focal HIFU or cryo routinely via HEAT and ICE registries, DM or email.
@UkFocal
@FocalSociety
@IP_London
Speaking today on
@BBCr4today
about sad news regarding Bill Turnbull
Key is early diagnosis
For that, we need a screening programme
To get screening, we need a massive study over the next 10-15 yrs to impact national policy
Support
@ProstateUK
Imperial Urology
@ImperialNHS
is delighted to welcome the internationally renowned Suks Minhas, Urologist/Andrologist who joins our permanent faculty from tomorrow.
I have the privilege and pleasure in welcoming Professor Rakesh Heer in joining Imperial College London.
These are truly exciting times for Imperial.
@imperialurology
@Heer_Lab
Just over a decade ago, Mark Emberton and I formulated a Nature Reviews Clinical Oncology perspective & position paper on the reasons to carry out pre-biopsy MRI & strategy to evaluate it.
@NatRevClinOncol
@IP_London
It’s come to the point where if you don’t offer focal therapy in your centre, you should offer referral to a unit that does
In UK at least, you’re breaking informed consent legal precedence, if you do not
Here are the focal therapy criteria
NB: NICE IPG & EAU guideline covered
⭐️ The EAU guidelines on focal HIFU and focal cryotherapy have changed ⭐️
For advice on eligibility criteria & how patients can access focal HIFU or cryo routinely via HEAT and ICE registries, DM or email.
@UkFocal
@FocalSociety
@IP_London
Focal vs radical
"Within the limitations of a cohort-based analysis in which residual confounders are likely to exist, we found no clinically relevant difference in cancer control conferred by focal therapy compared to radical therapy at 6 years"
RAPID is an example of the greatness that the NHS can achieve - from the pivotal PROMIS publication in Jan 2017 to sector wide pathway change 6 months later
Patients, general practice, management, radiology, pathology, urology - all working together for common purpose. Thank you
Myself, Mark Emberton and the PROMIS team around the UK are honoured to receive this award from
@Uroweb
and Fritz Schroder Foundation. Thanks above all to patients who agreed to take part.
@MRCCTU
@OfficialNIHR
Honoured to be appointed Chair, NHS England’s Prostate Clinical Expert Group with great Freddie Hamdy as Vice-Chair. Chance to align with research in my duty as Chair, NCRI Clinical Studies Group.
@Freddie_Hamdy
@NHSEngland
.
@NHSEnglandLDN
. Supported by
@ProstateUKProfs
Glad to be heading home from Oxford.
18yrs ago, I failed my medical finals here.
For not ‘accurately describing’ bladder catheterisation.
6yrs ruined by 1 flawed (surgical) examiner.
Inner self railed against being there today - it didn’t see the amusing irony of it all!
Imperial Prostate will be offering a Prostate Cancer Focal Therapy fellowship (Oct 2021 onwards)
UK (post-CCT, OOPT) or international urology trainees all welcome
Advert in next month. DM if interested
@IP_London
@imperialurology
@FocalSociety
@MMSiddiquiMD
@kareemfatairy
For literally decades, urologists who complain about a 5% miss-rate of prostate mpMRI have accepted a 30% miss-rate of TRUS biopsy. Cognitive dissonance at its worse.
I did this interview with a deep delve into my childhood, schooling and university life in the hope it might help others. Didn’t think I would get emotional at the end. Hope it doesn’t come across too navel gazing.
It is a pleasure to congratulate Mr Archie Hughes-Hallett who was appointed as Consultant Urological Surgeon with specialist interest in robotic and complex renal cancer surgery as part of the growing Imperial Bladder & Renal group within
@imperialurology
@archie_hh
10 years ago, Tim Wilt & I wrote rather negatively about screening, diagnosis & treatment of localised prostate in
@bmj_latest
BUT, with MRI, transperineal biopsy, active surveillance and focal HIFU & focal cryotherapy things are more positive now.
13 years after delivering an exemplary doctoral thesis, with the pivotal PICTURE MRI study at its core, Lucy Simmons, Consultant Urological Surgeon &
@ProstateUKProfs
Clinical Champion starts a focal HIFU programme in Bath
Proud to be there
@lucysimmons1
@prost8uk
@RUHBath
NICE guidance for Focal Irreversible Electroporation (Nanoknife) upgraded from ‘research & trials only’ to ‘special arrangements’
Can be offered outside of trials or research within a prospective audit registry (same as HIFU & cryotherapy NICE & EAU)
Another win for focal therapy
Prostate cancer focal therapy (using HIFU & cryotherapy) is cost effective compared to radical therapy
Lower cost, better quality of life
4 years to the day moving to Imperial College London
So many colleagues to thank at UCL where I 'grew up' & ICL for support and enthusiasm
Thanks to all patients whose care I have been privileged to be involved with
@IP_London
@imperialurology
@ImperialSandC
@profgeorgehanna
Great to be invited to speak at the Focused Ultrasound Foundation opening event at House of Lords.
@FUSFoundation
Pushing the clinical & research agenda for UK patients to access treatments like focal HIFU for prostate cancer, in partnership with Prost8
@prost8uk
Professor Hash Ahmed
@LondonProstate1
talks about the work they have done in west london to flip the diagnostic pathway to allow men to access rapid testing and MRI scanning in one day.
Congratulations to Deepika Reddy for best poster in session for abstract reporting excellent focal HIFU outcomes in the UK using transrectal (Sonablate) device.
@Reddy4Urology
@IP_London
@imperialurology
Great initiative BUT
You’ve missed focal therapy out as an option so again reinforcing the outdated unethical view that 12,000 men who are eligible for HIFU & cryotherapy every yr in UK are better off NOT told about it. You should correct ASAP.
These are the criteria👇🏽
We are excited to announce the launch of the infopool - a new, interactive website for people affected by prostate cancer. We are holding a Zoom webinar for healthcare profs on 25th April at 6pm - join us to learn more. Register at:
ATTENTON ALL UK UROLOGISTS
New
@IP_London
IP9-ATLAS 8 year RCT
Active surveillance RCT evaluating whether regular prostate MRI scans compared to standard care can better detect progression
Funded by NIHR HTA (£~2.6M)
Webinar for UK sites only - please email/DM me for login
Congratulations to Steph Guillaumier, Urology Specialist trainee for award of Research MD degree thesis on Focal HIFU on treatment of prostate cancer.
Pleasure being primary supervisor.
@SGuillaumier
@IP_London
And that’s it for
#ipmasterclass24
!
A big thank you from the
@IP_London
team to all our speakers, delegates, and industry 🙏
See you in 2025 for the next Imperial Prostate Masterclass jointly held with
@FocalSociety
!
And that’s a wrap on the
#IPmasterclass22
!
A massive thank you to all of our delegates and faculty - a small fraction of whom are pictured here
Till next time!
Harvest time of Bengali ‘mishti khodu’ or ‘sweet gourd’ grown from (approved, commercially packaged) seeds from Bangladesh.
Variable success from 2Kg to 7.5Kg!
@jteoh_hk
Shocking / disappointing how many would offer RARP.
Pt going to another surgeon is no excuse. ONLY option is AS. Treatment will cause harm and virtually no benefit.
No wonder screening committees have a field day on
#prostatecancer
Spot on with conclusions from
@declangmurphy
about the new paradigm in prostate cancer diagnosis following PRECISION RCT in NEJM today. Message for UK urology departments - shift practice urgently for all men.
#EAU18
@NHSEnglandLDN
@NHSEngland
Being honoured by Mayor Fozlur Rahman & Councillor Md Nahid Hussain of Moulvibazar Municipality (Pouroshoba), my town of birth in Bangladesh, with a surprise visit & award ceremony. Thank you to all.
It was very humbling.
9 focal PCa treatments today
5 focal HIFU cases & 4 focal cryotherapy cases today over two parallel lists.
All opportunities for training next generation of experts.
Business as usual every fortnight at
@IP_London
@imperialurology
with
@TaimurShah
This retrospective series, NOT approved by an ethics committee, should have brought about more outrage than the ENACT RCT of enza in AS.
What exactly was aim?
Pandering to patient fears that biopsy spreads cancer? Need to investigate that concern not bypass it in this way…
August 2022 Issue
Radical Prostatectomy Without Prior Biopsy Following mpMRI and PSMA PET
Editorial: Radical Prostatectomy Without Biopsy: Audacious, Imprudent, or Innovative?
COMPARE
Men with prostate cancer willing to prioritise quality over quantity of life.
Even trade-off survival gains (equivalent to those for radical therapy) for better genitourinary function.
Those suitable for focal therapy almost certainly don’t need to make that trade.
Heading to
#UROonc23
to explain tomorrow how focal HIFU and focal cryotherapy are standard approaches in managing localised prostate cancer.
Eligible men should be informed!
It’s come to the point where if you don’t offer focal therapy in your centre, you should offer referral to a unit that does
In UK at least, you’re breaking informed consent legal precedence, if you do not
Here are the focal therapy criteria
NB: NICE IPG & EAU guideline covered
1/6 Looking at discussion around delayed 2nd Covid vaccine strategy.
For those thinking ‘well, at least you’ve had 1 jab’, there are some issues.
Some argue that Pfizer are being too ‘pessimistic’ about outcomes.
Why? Because they looked at the FULL data (as they should)!
Really? Drive 30 minutes into town for a scan thats gives you a 2 in 5 chance of avoiding a biopsy, or have 12 needles thrust through the rectum at random straight up?
Or is it because they’re told they’ll have the needling anyway?
@urologistmaya
@LondonProstate1
@IP_London
Would love to MRI everyone prior. However it’s not available in my town, patients have to drive 30 minutes into the city to get it and many don’t want to do that. The logistical barrier to care is more of the realistic problem to underutilization.
You are invited to Professor Marcus Drake’s Inaugural Lecture
Let’s talk bladder - don’t be shy
Date: Wednesday 17 January 2024
Time: 17.30 – 18.30
Venue: YouTube / Lecture Theatre 200, City and Guilds Building
@imperialurology
Need a hand with exam prep?
@CRCPress
have released a study guide to prepare you for your FRCS(Urol) examinations!
With only 4 months to go until the next sitting, be sure to order yourself a copy today!
@Dr_Andrology
@UroShergill
@LondonProstate1
Congratulations to Dimitrios Papadopoulos, Imperial Prostate Focal Fellow for last 5 months, in being signed off as independent in carrying out focal cryotherapy (Boston) & focal HIFU (Sonablate).
Training from Mr Arya, Mr Shah (
@TaimurShah
) & myself
@IP_London
@imperialurology
Before Prof Hing Leung examined Jo Tam’s PhD thesis under supervision of
@Fletcher_C
@BevanLab
, we had an early morning catch up.
Hing was the lead panelist on my very first
@The_MRC
Clinical Research Training Fellowship imterview in 2007 (ever grateful)!
Lenny Marks PAIREDCAP study shows almost all MRI missed cancer 6/8 had PSA density >0.15. Important confirmatory evidence for role of triage and PSAD. UCLA consider no biopsy in MRI negative with low density.
#ftmasterclass
#UroSoMe
You really do make some offensive comments.
It is truly outrageous and should be called out by colleagues in radiation oncology for them,
I have no desire to debate with people who stoop to such lows.
Somehow despite largely single arm small trials and lots of retrospective data that is enough to have an entire meeting to spread training on focal.
Let’s be honest.
-It is to gain competitive advantage to do something different, not necessarily better
- gain quick cash at…
Professor Muhammad Bulbul of American University of Beirut Medical Center visiting Imperial Prostate
@ImperialSandC
Prelude to starting high quality focal therapy program using HIFU and cryotherapy.
@AUBMC_Official
Focal HIFU: 1,829 over 15yrs
Focal HIFU provides a safe alternative to treating the whole prostate for non-metastatic prostate cancer, with good 5-7 year cancer control
63%: Inter
26%: High
GG>/=2: 77.1%
Are ~8,000 eligible UK pts given fully informed choice?
#BAUS21
#BAUS2021
Congrats to our first IMPACT Award winner
@AJWLight
! His manuscript "mpMRI for assesing radiorecurrent PCa" been recognised as the most influential work featured in our Jan 2024 issue!
Read it here:
Watch the spotlight here:
Our second group of esteemed UK consultants looking to see how focal prostate therapy can fit into their units.
Bradford (Chidi Molokwu & Christos Gkikas)
Royal Marsden (Vincent Khoo)
Sheffield (Marcus Cumberbatch
@marcuskwesi
)
@IP_London
I’ve had both first doses & the booster vaccine.
I believe AND trust the science that it protects patients entrusted to my care, myself, my loved ones & friends, my colleagues & vulnerable members of my society.
It’s the way out of this pandemic.
Available in both print and digital formats Urology News provides an invaluable forum for the sharing of ideas and information in the field of urology and related specialties.
Subscribe here >
#urosome
@vishhanchanale
TRUS sextant biopsy upfront (known 50% sensitivity for significant cancer)
No MRI pre-biopsy
No protocolised Active Surveillance with either regular MRI or biopsy.
Absolutely NO relevance to current era.
No one should use this to justify treating low risk men. Unethical.
IMRIE is out! Our large cohort study found mpMRI could accurately exclude clinically significant PCa (>=GG2) in both specialist and local hospitals. We found a NPV of 90.6% when mpMRI was used in conjunction with PSAD cut-off of 0.15
@LondonProstate1
Thank you for the gift Dr Marks. The tie is in Latin. “Non illegitimi carborundum”.
“Don’t let the bastards grind you down”.
#ftmasterclass
#urosome
@UCLAHealth
leads the way in imaging and focal therapy.
My addendum to this great wake up call by Professor Walz.
Urologists involved in prostate cancer care should routinely offer and embrace focal therapy using HIFU and cryotherapy.
Consequently, the future will be very bright for the urological community.
Striking comments from Jochen Walz (1/2)
“…as surgeons we need to integrate new technologies and approaches in a more proactive manner in order to improve ontological and functional outcomes for our prostate cancer patients.“
Striking comments from Jochen Walz (1/2)
“…as surgeons we need to integrate new technologies and approaches in a more proactive manner in order to improve ontological and functional outcomes for our prostate cancer patients.“
New Words of Wisdom from Jochen Walz
Re: Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients with Localized Prostate Cancer: Results from the FLAME Randomized Phase III Trial
A comprehensive suite of treatment options
For patients with prostate cancer that needs treating,
Focal HIFU
Focal cryotherapy
Robotic prostatectomy (new robot arrived in March 2019)
Radiotherapy
For benign enlargement
TURP
HoLEP
Rezum
Urolift
PAE
It is with great sadness to let everyone know that Professor Paul Abel, Emeritus Chair of Urology at Imperial College London has passed away
His kindness combined with a wonderful sense of humour will not be forgotten
His legacy remains strong
@IP_London
@imperialurology
🏆 Our next award is the Professor Paul Abel Award for Lifetime Achievement in Prostate Cancer
🏆 We are delighted to award this to Professor Mark Emberton
@ucl
!
Citation by
@LondonProstate1
and presented by
@SageOfLondon1
Richly deserved!
#IPmasterclass22