Assoc. Prof. Tim Sargeant
@TimSargeant1
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Group Leader - Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, SAHMRI
Joined May 2018
Check out our latest Comment in @NatureCellBio on #autophagy (how cells of your body recycle damaged material). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea. @sahmriAU @UniofAdelaide
https://t.co/eh9Eu7I9hi
nature.com
Nature Cell Biology - Autophagy has long been presumed to decline with age, underpinning its designation as a hallmark of ageing. However, emerging evidence challenges this notion, showing...
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Gabriela Geraldo Benzoni (@fmrpusp) offers this #JournalClub article discussing time-restricted feeding and autophagic flux based on the recent work of Bensalem et al. (2025) ✍️ 🔗 Access it here: https://t.co/WQ1Viq9ipE
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ICYMI: Autophagy is a cellular recycling process linked to health span and modified by nutrition. Can one meal suppress it? @TimSargeant1 @sahmriAU show a high-protein meal does not alter autophagic flux in human peripheral blood mononuclear cells within 1 hour—challenging the
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"It's not the end of the world, let's just send it to another journal" https://t.co/fswwpXkBHU
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Autophagy is a cellular recycling process linked to health span and modified by nutrition. Can one meal suppress it? @SanjyySingh @TimSargeant1 @sahmriAU show a high-protein meal does not alter autophagic flux in human peripheral blood mononuclear cells within 1 hour—challenging
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Check out our recent paper from Lysosomal Health in Ageing on #autophagy in response to a high-protein milkshake in humans in @JCI_insight. A surprising negative result. Great job Dr @SanjyySingh! @sahmriAU
Our paper is out in @JCI_insight ! We asked a simple question: does a high protein shake after fasting change autophagy? Surprisingly, the answer was no – autophagy in blood cells did not change 1 hour after eating, despite clear metabolic responses. https://t.co/wcVubuje8C
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Dr Linh Dang and I penned this commentary on our own article that explores cell-type specific #autophagy in humans. We discuss #aging, sex, nutrient restriction, and the technology we need to better understand this process in people: https://t.co/Kv2Zq5GRUn
@sahmriAU
tandfonline.com
Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a ...
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Well worth a five minute read - Interventional study showing lifestyle interventions boost #cognition during #aging - the structured intervention group focused on #exercise, #diet advice, and cognitive exercises. Lifestyle is important for #brain aging!
U.S. POINTER confirms that lifestyle change can boost cognition in older adults. https://t.co/GKC3dW89zm
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Want to get 31% "younger" biologically? Play 90 mins of Bundesliga soccer. The catch? You're back to baseline within 24 hours. 🤣This isn't hype, it's a wild finding! A new study reveals GrimAge (the most robust epigenetic clock for mortality risk) shows a significant dip after a
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The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy. 👏 Congrats to our Keystone scholarship awardees—your future in science is bright! 🔗 https://t.co/4NuGmKRIlu
#KSAutophagy25 @bealelab
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Well done @SanjyySingh for receiving important recognition for your work on #autophagy at the recent Keystone Symposium in Canada
The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy. 👏 Congrats to our Keystone scholarship awardees—your future in science is bright! 🔗 https://t.co/4NuGmKRIlu
#KSAutophagy25 @bealelab
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New research paper on human #autophagy from our group at @sahmriAU. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: https://t.co/mYqp5J8dsW
#aging
faseb.onlinelibrary.wiley.com
We previously established a whole-blood assay to measure autophagic flux by adding chloroquine to whole blood to inhibit lysosomal degradation of autophagosomes. We adapted this technique to flow...
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Our paper about how autophagy changes in mice as they age is now available at @PLOSONE ! Big thanks to @TimSargeant1 , @turnerMNDlab & team, as well as @sahmriAU , @uniofadelaide & @hosp_research ! https://t.co/woZossXk7k
journals.plos.org
Autophagy is a ‘waste-disposal’ pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet the role that sex and diet-related obesity play during...
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A/Prof @TimSargeant1 is the latest guest to feature on the Community Conversations podcast. 🎙️ A/Prof Sargeant discusses all things autophagy - the latest research, tips for optimising cellular health and more! Listen 🎧 https://t.co/H6kmdiP0BC
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Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: https://t.co/TrmWE3KNvQ Join us for five inspiring days of cutting-edge autophagy research!
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I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: https://t.co/8Ttunj0RuH
#isa11
isa11.org
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Crucial new pilot study to investigate whether #rapamycin can be used against dementia causing diseases published yesterday. https://t.co/8fzZ9I53G5
nature.com
Communications Medicine - Gonzales et al. conducted an open-label phase 1 clinical trial of rapamycin for mild cognitive impairment and dementia due to Alzheimer’s disease. Rapamycin is not...
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NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy Huh? Is fasting still worth it? ... 🧵
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In a recent study published by our group, we measured autophagic flux in human PBMCs. We cannot yet measure #autophagy in organs, which is why we are developing tissue specific autophagy biomarkers.
They didn't measure autophagy in liver, kidney, or any other tissue, which might be more responsive to diet and more important for health and longevity
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