The Roberts Lab
@TheRobertsLab1
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The lab of Charlie Roberts at @stjuderesearch studying SWI/SNF chromatin remodeling complex. Tweets are from lab members unless signed CR.
Joined August 2019
The Roberts Lab is looking for highly motivated, intellectually engaged candidates with an interest in #ChromatinBiology to fill a Researcher position. Check out the link below and feel free to reach out with any inquiries!
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Fascinating new @CellReports paper from @HainerLab directly comparing the effects of all SNF2 family chromatin remodelers upon transcription of mRNAs, eRNAs, and uaRNAs in ES cells.
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RT @StJudeResearch: Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continu….
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The Roberts Lab is looking for highly motivated, intellectually engaged candidates with an interest in #ChromatinBiology to fill a Researcher position. Check out the link below and feel free to reach out with any inquiries!
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We are excited to have Kirill Miachin, an MD,PhD student from @GarciaLabMS's lab train with us for the next two weeks. Welcome aboard, Kirill!
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Check out this fantastic Research Highlight covering our recent work with @HongYue88665668 @fischerlab1 on DCAF5 published in @Nature. Original Tweetorial linked below!.
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Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate @stjuderesearch #swisnf (1/9)
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We are delighted to see our Review featured on the cover of the September issue of @NatRevDrugDisc. Original tweetatorial is linked below! @HaydenMalone3 @StJudeResearch @stjudegraduate.
Our September issue is live! Read about muscarinic receptor modulators for schizophrenia, chromatin remodellers as therapeutic targets, lipid nanoparticles for nucleic acid delivery, new epilepsy therapies in development and more here
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Join me in The Science of Childhood Cancer lecture series this Thursday, September 5 at noon CT/1pm ET where I will be presenting “Chromatin and Cancer: from mechanisms to emerging therapies.” Register to attend: CR
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We are deeply grateful to our funding sources: @NIHfunding, @theNCI, @CureATRTNow, The Garrett B. Smith Foundation, and @StJude. We also extend our thanks to our institutions for their collaborative support: @StJude, @StJudeResearch @StJudeGraduate, @UMich, and @Penn.
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@xubeisi, @YiannisDrosos, @ShondraP_Miller, Mats Ljungman, @GarciaLabMS, @wufgang and @JanetPartridge7.
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We thank all co-authors who contributed to this work:@priya1012007,@jackiem_bioinfo,@raymonddcarter, Sandi-Radko-Juettner, @HaydenMalone3, Wojciech Rosikiewicz, Alexis Robertson, @ZhexinZhu, Ishwarya Narayanan, Baranda Hansen, Meadow Parrish, Natarajan Bhanu, Jerold E. Rehg.
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Together, PHF6 facilitates the recruitment of #SWISNF complexes to regulate transcriptional licensing via the release of #RNApolymerase.
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PHF6 recruits bromodomain-containing subunits of the #SWISNF complexes (SMARCA4, PBRM1, and BRD9) that recognize H3K14 acetylation.
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Specifically, PHF6 regulates H3K14 and H3K27 acetylation by recruiting the histone acetyltransferase p300.
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Through this discovery, we gained new insights into how PHF6 functions as a dynamic hub, regulating the crucial interface between chromatin and #Transcription.
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We identified PHF6 as a critical #dependency for the survival of #SMARCB1-mutant cancers through #CRISPR screenings conducted in collaboration with @cancerdepmap.
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