Exciting news - Our lab is recruiting a postdoc to join our explorations into the Plasmodium cytoskeleton. Do reach out if you'd like further details. Apply here; closing date 8th Sept: https://t.co/hyGSoTK9XG

We also discovered 4 previously uncharacterised proteins, which we named centromeric subunits 1-4 (CS module), functionally repurposed from the outer kinetochore Dam1/DASH complex. It will be very interesting to see how many other species contain this CS module

Interestingly, this species also lost centromeric CENP-A nucleosome, but instead evolved a unique histone fold protein that dimerises via non-canonical interfaces to fold the DNA

We discovered that holocentric kinetochore assembles into a self-contained, head-to-head dimer that topologically entraps and loops DNA, creating a point-centromere-like architecture.

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! https://t.co/PP5oUXVdvW

Wonderful meeting at the Centromere Biology Gordon Conference in Maine! Lot of great science and nice friends to meet! Thanks @centromellone and @iaincheeseman for organizing it! @astraight @oegemadesai_lab @larsjansenlab @Foltz_Lab @StanislauY

New work from @palconh in my group shows that DNA repair proteins FANCD2-FANCI slide on double-stranded DNA. Surprisingly they specifically recognise single-stranded junctions #cryoEM Our first foray into single molecule imaging thanks to @RuedaLab @MRC_LMB @MRC_LMS Thread here:

Over and out for the Centromere Biology GRS! Great talks, great panel discussion, and a great intro to the GRC week ahead! Thanks to everyone who helped make these two days a success!

Last year, Stanislau Yatskevich (@StanislauY, then @MRC_LMB) won a Birnstiel Award for his groundbreaking research on chromosome segregation. His talk is now available online:

A gentle reminder that there is less than 1 month to register for the centromere biology GRS & GRC! The GRS is almost (!) fully subscribed so get your applications in ASAP if you wish to present a poster. We have a great lineup of speakers and mentors so don’t miss out!

When I joined David Barford's group @MRC_LMB it was with the goal of using my cryo-ET and computational skills to help them understand funky biology. I joined @TDendooven and @StanislauY's efforts to average the native gamma tubulin ring complex (γTuRC) from tomograms of SPBs

Happy to see one of the last pieces of my PhD work published! Very lucky to have awesome @TDendooven as a partner in crime Also many thanks to @AlisterBurt, Dom, John, David and @RappsilberLab

Excited to see this work from @StanislauY and I out in @NatureSMB! We averaged the native yTuRC from Yeast SPBs, and discovered a novel coiled-coil protein stapling the Tubulin lattice to yTuRC. Huge thanks to @ABurt, David, John, @RappsilberLab and Dom! https://t.co/SpCaAtDdLt

Our new paper about the structural mechanism by which RAD51 assembles at double-stranded DNA break sites on chromatin has been published in Nature! https://t.co/bR8Oxjv8RP #CryoEM #Nucleosome #RAD51 #DNArepair

Thank you! It was a pleasure to coordinate the publications

Happy to see our work on the structure of the outer kinetochore in print https://t.co/VvKmx2snJy Special thanks to David, Dom, @JYang188 and @ZhangZiguo Glad to see the complementary study by @AndreaMusacchi1,@polley_dilse and @TobiasRaisch in the same issue! Congratulations 🎉

Congratulations @ElyseFischer7, @connyyu, David and co authors! Insightful work on the mechanism of Mad2 conversion by Cdc20 to a closed, active state 🎉

Very insightful work on the gamma-TuRC activation mechanism

Phenomenal work on the yeast outer kinetochore! Congratulations 🎉