Siyu Chen
@SiyuChen91
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Graduate student at @NorthwesternU @YuanHeJHU HHMI @JCChildsFund fellow at @UCSD @TheVillaLab #CryoEM #TeamTomo
Joined March 2021
RT @EisFabian: SPACEtomo v1.2 is online! - Improved GUIs for lamella detection, target selection and CLEM registra….
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Huge thanks to our best LRRK2 team member @TheVillaLab and the @aleschziner group with in the @ASAP_Research team who I worked with all the time!.
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Check out our new preprint revealing an unidentified LRRK2 oligomerization state on microtubules: Satisfying first attempt working on the cryo-ET #TeamTomo data led to a nice piece of finding😌 More to come on this versatile and intriguing protein!.
biorxiv.org
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. Mutations in leucine-rich repeat kinase 2 (LRRK2), a multi-domain protein containing both a kinase and a GTPase, are a...
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Huge honor to receive this reward! Many thanks to @thermosciEMSpec! This means a lot to me.
Please give a big round of applause to @SiyuChen91, @thermofisher's 2023 #CryoEM Grant Program Silver Winner!. Siyu is a postdoctoral fellow at @TheVillaLab at @UCSanDiego / @HHMINEWS. Learn about his research proposal here:
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Truly honored and excited to join the cohort of 2023 @JCChildsFund fellows. Many thanks to everyone in @TheVillaLab and @YuanHe_NWU. Nothing would be possible without you all.
jccfund.org
NEW HAVEN, CT– June 27, 2023 – The research landscape has changed greatly since the Jane Coffin Childs Fund for Medical Research (JCC) first awarded fellowships to postdoctoral scientists almost 80...
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Also don't forget to check out this complementary study from @AmandaChaplin10 and colleagues:.
science.org
PAXX and XLF structurally bridge alternate forms of DNA-PK dimers, explaining the redundancy between XLF and PAXX in NHEJ.
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Many thanks to everyone in the He lab (miss you guys so much!!) and as always, our wonderful collaborators Susan Lees-Miller and Alan Tomkinson!.
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Glad to present the second part of my thesis project done with @YuanHe_NWU! Using #CryoEM, we visualized how DNA-PKcs adopt different intermediate states during NHEJ #DNArepair and how a scaffolding factor, PAXX, stabilizes the complexes. Please check
science.org
Three transitional states in NHEJ reveal distinct DNA-PKcs dimeric form and a likely conserved mechanism of PIKK family kinases.
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RT @TheVillaLab: #teamtomo tweeps, @lindsey__young wrote a tell-all. Clutch your pearls and get ready to plan your project! (Or explain to….
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RT @MarlovitsLab: Resolving the AAA+ ATPase Puzzle in Slow Motion. Cutting-edge cryoEM, time-resolved studies and slower burning fuels. Bi….
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RT @deniswirtz: Rather stunning, but here we are: we have identified 552 funding opportunities that are specially targeted to early-career….
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RT @cryoEM_Papers: Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids .
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RT @cryoEM_Papers: In situ architecture of the ciliary base reveals the stepwise assembly of IFT trains
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RT @cryoEM_Papers: In situ Alphavirus Assembly and Budding Mechanism Revealed by Cellular CryoET
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RT @aschuller17: Excited to share my work from @SchwartzLabMIT in @MITBiology titled “The cellular environment shapes the nuclear pore comp….
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RT @cryoEM_Papers: Whole-cell organelle segmentation in volume electron microscopy
nature.com
Nature - Focused ion beam scanning electron microscopy (FIB-SEM) combined with deep-learning-based segmentation is used to produce three-dimensional reconstructions of complete cells and tissues,...
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RT @iamscicomm: A thread on understanding the importance of 'complementary colors' in science figures 🎨👇🏼.(tl;dr, it will enhance color har….
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RT @HHMINEWS: HHMI News: We are proud to announce our 33 new #HHMIInvestigators. These individuals have the potential to make transformativ….
hhmi.org
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