TomoTwin official release pt 1 🥳! After some code streamlining and writing documentation we’ve released the first stable build of TomoTwin. Here’s an example of TomoTwin picking Tc toxins based on a single reference without having to be trained on the protein beforehand. 🧵1/6

RT @FitzpatrickLab: Forward-looking preview by @WUBin10069342 to our latest paper @Structure_CP by @AndrewNChang highlighting the power of….

RT @mpimoph: Sebastian Tacke has been honored with the Paper of the Year Award by the Journal of Structural Biology @ElsevierConnect for h….

RT @fchollet: One more piece of evidence to add to the pile. This was an extremely heretic viewpoint in early 2023, and now it is increasin….

RT @ChailletMarten: Really happy to share that the last chapter of my submitted phd thesis is already on biorxiv!🥳.Using a tophat transform….

RT @mpimoph: We are proud of @oleg_sitsel former @Intein lab postdoc .who is now Assistant Professor and head of the Marine Structural Biol….

RT @maikaboiero: Curious about the molecular mechanism of #actin elongation by #formins?.Then check out our latest work in @ScienceMagazine….

Termine in anderen Monaten als April sind gar nicht erst buchbar. Ist das euer Ernst? Erinnert mich an die Erfahrungen aus der letzten Folge der @LageNation. .

RT @oleg_sitsel: So proud that our Tc toxin release story with @Intein was featured on the cover of today's @NatureMicrobiol issue! 🎉.Check….

RT @alexanderbelyy1: Are you ready to meet the #toxin with the most AWESOME name? Say hello🤗 to The Makes Caterpillars Floppy 1 toxin! It t….

RT @oleg_sitsel: My lab has exciting openings for postdocs/staff scientists and a technician. Involves super-cool projects, a dynamic inter….

RT @oleg_sitsel: It is my great pleasure to announce that I am joining @OISTedu as faculty!.My lab will focus on characterizing our oceans’….

RT @oleg_sitsel: Our paper revealing how specialized #Yersinia cells 🦠release a deadly Tc toxin-containing cocktail ☣️ by blowing themselve….

RT @mpimoph: Read how a few soldier cells armed to the teeth confer virulence to an entire bacterial #Yersinia population by sacrificing th….

RT @NjengaPAN: Very excited to share our preprint on the multi-state kinetics of the syringe-like injection mechanism of Tc toxins. Great c….

Great example (thx @proteincapsid for the tomogram) to experience how TomoTwin organizes the embedding space. The virus center is located in a completely different region than the "envelope" :-) Optimized clustering workflow will be released soon

RT @oleg_sitsel: Big thanks to (twitterless) Vicky Trinkaus,.@Intein and all our speakers for a stunning 2-day cryoEM/ET winter school @mpi….

RT @pixelbaumarkt: TomoTwin 0.7 is out and ready to use for #TeamTomo :-) This release adds new tools for advanced strategies that describe….

The second strategy creates masks using an estimate of the average background embedding. It can exclude large portions of irrelevant regions, dramatically speeding up the embedding step and allowing the umap to focus on relevant embeddings.

The first strategy helps you to refine manually selected references or cluster targets using umaps.

TomoTwin 0.7 is out and ready to use for #TeamTomo :-) This release adds new tools for advanced strategies that describe how to speed up the calculation of embeddings, potentially improve their umaps, and how to refine references/targets! 🧵. All changes: