SchwartzLabMIT
@schwartzlabmit
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Nucleo-cytoplasmic communication. MIT, Department of Biology @MITBiology #structuralbiology #cellbiology #cryoEM #Xrays
Cambridge, MA
Joined October 2018
New paper from the lab out today on how the assembled HIV-1 capsid mimics nuclear transport receptors to pass the nuclear pore complex. Fantastic collaboration with Dirk Görlich @mpi_nat !.
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Congratulations to all the labs that have contributed to this extraordinary feat @hoelza @Beck_Laboratory @jankosinski @WuLabHarvard and others. Looking forward to seeing the structural knowledge being used for detailed functional analyses in the future.
A new special issue of Science reveals a near-atomic picture of the human #NuclearPoreComplex—an elaborate structure composed of hundreds of proteins that mediates the exchange of material between a cell’s nucleus and the surrounding cytoplasm. Read more:
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Very sad to see Ned Seeman pass away. One of my favorite papers from grad school, back then in the pre-PDF era proudly photocopied in the cavernous MIT library. One of the great Rich lab alumni. What an inspiration he was.
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RT @MITBiology: A team led by @aschuller17 & @schwartzlabmit found a way to analyze the nuclear pore complex directly inside cells. The por….
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RT @aschuller17: Excited to share my work from @SchwartzLabMIT in @MITBiology titled “The cellular environment shapes the nuclear pore comp….
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Out today: Native environment significantly influences shape of the NPC. First venture into cryo-ET. Great work by the infatigable @aschuller17 and wonderful collaborators: Medalia lab @UZH_ch @KarstenWeisLab @MDassolab @mit_nano @kochinstitute.
nature.com
Nature - Structure of human nuclear pore complex in its cellular environment reveals a substantially dilated central channel and shows that its nucleoplasmic and cytoplasmic rings restrict channel...
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BIG Congratulations to Elizabeth @TheVillaLab for becoming a new HHMI investigator! Great to see.
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