MPI Dortmund
@mpimoph
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'Bridging scales' from #smallmolecules to #cells. How can we combat the development of #humandiseases like #cancer? Max Planck Institute of Molecular Physiology
Dortmund, Deutschland
Joined March 2016
Pushing calcium against the flow: high-speed pumps in the cell - The first comprehensive transport model of a plasma membrane calcium pump explains its high speed and opens up new avenues for drug development.➡️
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paper alert🚨.Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - published by @Intein lab @maxplanckpress & Fakler lab @UniFreiburg in @Nature - congrats to @oleg_sitsel et al.
nature.com
Nature - Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.
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Decoding the language of PLK1 docking motifs and activation mechanisms - #Review from the Musacchio Lab in @TrendsCellBio .➡️
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Packing 🧬DNA on time for cell division .Trans-European research team discovers how a molecular switch controls DNA packing on time for cell division. Read the story ➡️
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RT @mpgpresident: Ein starkes Signal für Wissenschaft und Innovation! Vielen Dank an den Freistaat Bayern, @Markus_Soeder und @MarkusBlume….
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🚨Paper alert.Condensin II activation by M18BP1 - published by Musacchio Lab & @VanniniLab @humantechnopole & Rowland Lab @NKI_nl in @MolecularCell . ➡️
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Arp2/3-complex regulation - Novel insights and open questions - published by Peter Bieling, Micaela Boiero Sanders and Theresia Stradal in Curr Opin Cell Biol.
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🚨Paper alert🚨.Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex - published by the Musacchio Group @maxplanckpress in @NatureComms .
nature.com
Nature Communications - The spindle assembly checkpoint protects cells from chromosome missegregation. Here, the authors use sophisticated biochemical reconstitutions to address how kinetochores,...
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The Max Planck Institute in Dortmund mourns the loss of Philippe Bastiaens.
mpi-dortmund.mpg.de
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With great sadness and deep regret, we have to inform you that our department director and highly esteemed colleague Philippe Bastiaens @maxplanckpress passed away suddenly and unexpectedly on 15th of May.
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RT @maxplanckpress: In a twin study, researchers @MPIforBI successfully characterized gut bacteria involved in #MultipleSclerosis and provi….
mpg.de
Study of twins detects bacteria in the small intestine that play a role in the development of MS
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There are currently high hopes for the development of novel Parkinson's drugs. @MalteGersch group has now deciphered the mode of action of these drugs. The findings can help to develop innovative therapeutics for #Parkinsonsdisease & other disorders.
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New Parkinson’s disease paper:.Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by @MalteGersch group @maxplanckpress in @Nature Struct. & Mol. Biol.
nature.com
Nature Structural & Molecular Biology - Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP30, a clinical stage Parkinson’s disease drug target, in complex...
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An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products - New publication by the Waldmann Group published in @ChemBioChem .
chemistry-europe.onlinelibrary.wiley.com
An indole-dearomatization/reduction strategy is developed to expand a collection of indole-containing pseudo-NPs. This approach enhances the three-dimensionality of the original compound classes...
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We congratulate Max Haase, #Postdoc in the lab of Andrea Musacchio, on receiving the highly-coveted @MSCActions Postdoctoral Fellowship funded by the @EU_Commission
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🚨Paper alert🚨 The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning - Published in @embojournal by the Peter Bieling Group & @BementLab & Scott Hansen Group.
embopress.org
imageimageFormation of Rho GTPase activity patterns on the plasma membrane is key to numerous morphogenic processes in eukaryotic cells. This study employs a reconstitution approach to reveal the...
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RT @maxplanckpress: 🚀 Exciting news for early-career researchers! . The new Max Planck #Postdoc Program offers a guaranteed contract of at….
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RT @JCellBiol: Interactions with multiple inner #kinetochore proteins determine mitotic localization of FACT, say Julia Schweighofer, Bhagy….
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