Stuart Schreiber
@SchreiberStuart
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Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Boston, MA
Joined August 2018
1/4 A Perspective on proximity-inducing #molecularglues and bifunctional compounds in relation to hot-spot-associated missense mutations enshrined by natural selection and posttranslational modifications (PTMs).
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Excited to see this dynamic duo tackling high-impact biomedicine – among others, AI for reasoning on human evidence and AI for informed therapeutics
forbes.com
Morgan Cheatham, a physician-informaticist and former Bessemer VC, joins Breyer Capital to lead healthcare and life sciences at the intersection of AI and biomedicine.
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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Under this ownership group, the Celtics won two championships and built a culture of camaraderie and resilience. Steve's deep loyalty to Boston makes him a champion both on and off the court, leaving a legacy that will forever inspire Celtics fans and Bostonians alike.
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From @m2jr in Pattern Breakers (quote from William Gibson): "The future is already here; it's just not evenly distributed." . What's true of technology is true of medicine – we need insights into the inflection points to unlock transformative biotechs . #SXSW2025.
It’s go time for @SXSW! 🚀. today with Jim Breyer. I’m excited to share the stage this afternoon with my longtime friend and one of the best in the business, @jimihendrixlive, to explore the forces that drive startups to outlier success. Join us on the main stage (Salon H) at.
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Heartfelt congratulations, Jiaqi and Smriti, on this well-earned recognition. I'm proud to have my name associated with yours.
Congrats to the winners of the Stuart L. Schreiber Prize in Scientific Excellence presented at the @broadinstitute 's annual retreat! @JiaqiZhangVic (top) won for outstanding work on causal inference AI and @Smriti__Pandey (bottom) for pushing the frontiers of genome editing.
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RT @ChemistryNews: Scientists create vast library of compounds to target disease proteins
phys.org
Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat...
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RT @TrevorZandi: Compounds that recruit FKBP12 to novel targets with high cooperativity are the prototypical molecu….
biorxiv.org
Molecular glues are small molecules that engage their target and presenter proteins cooperatively. FKBP12 molecular glues (FK506 and rapamycin) were discovered several decades ago and have been used...
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PUFAs provide membrane fluidity and promote extravasation, but also result in vulnerability to a ferroptotic grease fire:.
We are delighted to share the most recent work from our lab at Westlake University:.ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization: Cell
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RT @harveyjberger: @HowardYChang is a phenomenal choice for the CSO role at @Amgen. Kudos to @jaybradner for shooting for the stars and rec….
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Learning from the Generative AI community and exploring opportunities to interface with human biology at the Liquid AL Conference at MIT – a promising frontier.
I had a fantastic time at the @LiquidAI_ conference in Boston this week. We're just scratching the surface of what I believe will revolutionize nearly every aspect of society. For a quick recap, check out @TheAiGrid’s summary here: There’s a lot to
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RT @MichaelDell: Everybody gets angry. But don’t stay angry. Anger is counter-productive. Instead, be motivated by a desire to help others….
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RT @arenabioworks: First-time dad Travis Blum knows that bringing something new into the world is hard, messy work, and about the most rewa….
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RT @CFLabsResearch: Inspired by findings from @TSharifnia & @SchreiberStuart that GPX4 is essential in chordoma, we’ve demonstrated that GP….
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Proximity-inducing #molecularglues for RAS- and RAF-dependent cancers.
A Brain-Penetrant pan-RAF–MEK Non-Degrading Molecular Glue for Untreated RAS- and RAF-Driven Cancers. Read the full article to learn about NST-628’s fascinating MoA, how it differentiates, why this molecule is a big deal, and more!. LINK |
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Bravo Damian!.
I am extremely grateful to be awarded a $5,000,000 Catalyst Grant from the Welch Foundation. This grant will be focused on further developing the science of DNA-Encoded Libraries (DELs) for generating small molecule ligands toward a broad spectrum of disease-related targets.
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Hallmark of oncogenic mutant p53? Exceptionally high levels of expression. How to exploit for treating cancers? A bifunctional Chemical Inducer of Proximity (CIP) that targets a cytotoxic small molecule to mutant p53 cancers. See thread by @wgibson.
TP53: .- Discovered 45 years ago, most cited gene all time.- No therapies.- 500 million people currently living will die of TP53 mutant cancers without new therapies. Our Preprint: .- A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
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RT @arenabioworks: Polyglot Giulia Oliva speaks English, Greek, French, and her native Italian. She would love to learn more but is busy wi….
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RT @RLCscienceboss: Cool story from @leilei_wuu on Broad scientists that made a new, compact #epigenetic editing tool small enough to fit i….
endpoints.news
Researchers from MIT and Harvard have crafted a new tool to silence genes without editing their sequence and are using it to develop a treatment for prion disease, a fatal ...
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RT @CellChemBiol: #Perspective #Featured #OpenAccess from @SchreiberStuart at @arenabioworks @broadinstitute: on proximity-inducing molecul….
cell.com
In this Perspective, Dr. Stuart Schreiber provides a comprehensive insight into proximity-inducing compounds—molecular glues and bifunctional compounds, drawing analogies to hot spots, missense...
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RT @harveyjberger: Inhibiting PRDX6 to induce #ferroptosis may be a compelling target for #cancer therapy. Beautiful study from one of the….
nature.com
Nature Structural & Molecular Biology - The authors identified PRDX6 as a novel selenoprotein synthesis factor performing an iron-induced ferroptosis screen. They reveal that PRDX6 greatly...
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