Chordoma Foundation Labs
@CFLabsResearch
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Patient driven research laboratory 100% dedicated to accelerating cures for chordoma. A program of @ChordomaFDN.
Durham, NC
Joined March 2024
This from @sajithw pinpoints a big source of drag in research and drug development: “Each lab reinvents how experiments are designed, samples are identified, complex data are structured, analysis pipelines run, and results are shared. That’s not even considering work that’s
Long time lurker, breaking a decade of silence to share an essay on what I've learned from scientists about making medicines (spoiler: it's hard) and why the future looks bright (also spoiler: AI) 🧵
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New TBXT targeting tools and potential therapeutic targets in the TBXT regulatory network identified by our colleagues Drs. Umbaugh, Scholl @StefanFrohling and team at @DKFZ & @NCT_HD. Exciting work and lots for the field to build on!
science.org
Designed ankyrin repeat proteins targeting the embryonic transcription factor TBXT provide insights into chordoma biology.
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We're seeing nice synergy between inhibitors of PKMYT1 and Wee1 in chordoma cells, suggesting a possible combination therapy approach to exploit replication stress in chordoma. Initial results now on @figshare. More to come on this.
figshare.com
To evaluate PKMYT1 inhibition and Wee1 inhibition as a potential combination therapy in chordoma, chordoma cell lines were treated with Lunreseritb and Debio 0123 as single agent treatments and as a...
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Latest negative result: Response of chordoma cell lines to treatment with the KIF18A inhibitor sovilnesib (AMG 650), as a single agent and in combination with gemcitabine
figshare.com
To evaluate KIF18A inhibitors as a potential therapeutic target, chordoma cell lines were treated with sovilnesib. A panel of four chordoma cell lines was seeded in a white-walled 96-well plate so...
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monitoring the situation as a shipment of precious chordoma samples from our biobank flys to Melbourne for our collaborators in the Firestein lab at @Hudson_Research ✈️ 🇦🇺
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Potent GCL inhibitors that induce #ferroptosis (cell death) are ineffective in vitro in chordoma-sensitive cell lines. Highlights the importance of understanding cell-state dependencies in cancer. Negative results are as important as positives.
Positive results get publications and fanfare, but we think sharing negative results is important too. In case this can be helpful to anyone, here are some compounds we tested in vitro in recent months which didn't show substantial activity as single agents or synergy with known
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Preclinical chordoma models are insensitive to DNA Polymerase θ inhibition, even when combined with replication stress inducer gemcitabine
figshare.com
To evaluate DNA Polymerase θ as a potential therapeutic target, chordoma cell lines were treated with ART558. A panel of 4 chordoma cell lines were seeded in a white-walled 96-well plate so that at...
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Response of chordoma cell lines to the PRMT5 inhibitor AMG 193
figshare.com
To evaluate PRMT5 as a potential therapeutic target in chordoma, MTAP-null (A-C) and MTAP-positive (D-E) chordoma cells were treated with the PRMT5 inhibitor AMG 193 as a single agent, AMG 193 +...
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Response of chordoma cell lines to the DNA-PK inhibitor M3814 https://t.co/8AF88KBhOO
figshare.com
To evaluate DNA-PK as a potential therapeutic target, chordoma cells were treated with the DNA-PK inhibitor M3814 as a single agent and in combination with elimusertib, an ATR inhibitorCell lines...
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Response of chordoma cell lines to the Aurora A kinase inhibitor Alisertib
figshare.com
To evaluate Aurora A kinase as a potential therapeutic target, chordoma cells were treated with the Aurora A kinase inhibitor alisertib as a single agent and in combination with gemcitabine.Cell...
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Chordoma preclinical models are insensitive to BAF complex inhibitor FHD-286, alone or in combination with gemcitabine
figshare.com
To evaluate BRG1(SMARCA4)/BRM(SMARCA2) as a potential therapeutic target, chordoma cell lines were treated with FHD-286. A panel of 4 chordoma cell lines were seeded in a white-walled 96-well plate...
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Response of chordoma cell lines to PKMYT1 inhibitor Lunresertib as a single agent and in combination with the ATR inhibitor Elimusertib
figshare.com
To evaluate PKMYT1 as a potential candidate for combination therapies in chordoma, chordoma cells were treated with the PKMYT1 inhibitor Lunresertib in combination with the ATR inhibitor Elimusertib...
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Positive results get publications and fanfare, but we think sharing negative results is important too. In case this can be helpful to anyone, here are some compounds we tested in vitro in recent months which didn't show substantial activity as single agents or synergy with known
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🗣️ We're hiring a Director of Preclinical Research! This is an exciting opportunity for an oncology R&D leader to make a tangible impact in the lives of patients in urgent need of new treatment options. More info: https://t.co/xcym3teQKO
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Happy the TBXT Challenge is inspiring new approaches to take on this important target and appreciative of everyone making that happen!
Qubigen Joins the TBXT Challenge to Accelerate Discovery of Lead Candidates for Chordoma.
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@rcsbPDB @ZENODO_ORG So others don't have to reinvent the wheel, we've developed and offer capabilities to support TBXT drug discovery including purified protein production, SPR and various functional assays. For more info see below or get in touch: researchteam@chordoma.org https://t.co/JW2sJicm2s
chordomafoundation.org
TBXT, also called Brachyury, is a key driver and genetic dependency of chordoma, and is associated with disease progression in various other tumor types.…
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Fascinating: the chordoma associated TBXT SNP rs2305089 also causes a predisposition to benign notochordal cell tumors—with 15% of chordoma patients harboring a BNCT and 6% harboring more than one. Great work from @iusher3 @CottoneLucia @uclcancer!
pathsocjournals.onlinelibrary.wiley.com
The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed...
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