Chordoma Foundation Labs
@CFLabsResearch
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Patient driven research laboratory 100% dedicated to accelerating cures for chordoma. A program of @ChordomaFDN.
Durham, NC
Joined March 2024
RT @ChordomaFDN: 🗣️ We're hiring a Director of Preclinical Research! This is an exciting opportunity for an oncology R&D leader to make a t….
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Happy the TBXT Challenge is inspiring new approaches to take on this important target and appreciative of everyone making that happen!.
Qubigen Joins the TBXT Challenge to Accelerate Discovery of Lead Candidates for Chordoma.
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RT @CFLabsResearch: @rcsbPDB @ZENODO_ORG So others don't have to reinvent the wheel, we've developed and offer capabilities to support TBXT….
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Fascinating: the chordoma associated TBXT SNP rs2305089 also causes a predisposition to benign notochordal cell tumors—with 15% of chordoma patients harboring a BNCT and 6% harboring more than one. Great work from @iusher3 @CottoneLucia @uclcancer!
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RT @ChordomaFDN: We're happy to share that @PyxisOncology's Phase 1 trial of PYX-201 (Micvotabart pelidotinaka “MICVO”) has opened to patie….
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RT @weldeiry: Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy. https://t.….
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RT @zoecournia: TBXT CHALLENGE: DRUG THE UNDRUGGABLE.Compete for $500K+ in prizes for breakthroughs in developing drugs for the cancer-asso….
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@rcsbPDB @ZENODO_ORG So others don't have to reinvent the wheel, we've developed and offer capabilities to support TBXT drug discovery including purified protein production, SPR and various functional assays. For more info see below or get in touch: researchteam@chordoma.org.
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@rcsbPDB @ZENODO_ORG We're excited to see how others build on these data including to compete in the TBXT Challenge (offering >$500K in prizes for more potent binders)
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Crucial building blocks for drugging TBXT (brachyury) published by @UNCPharmacy @UniofOxford @ICR_London team including crystal structure, discovery of ligandable pockets, and compounds that could serve as starting points for inhibitors or degraders.
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RT @CFLabsResearch: For those undaunted by drugging the currently undruggable: we're excited to announce the TBXT Challenge, a drug discove….
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John Henry Owen and the @UMichOto @umichheadneck team are unsung heroes of chordoma research for developing and willingly sharing a number of the workhorse cell lines we and other labs use daily. We’re deeply grateful for their tireless and meticulous efforts over many years!.
John Henry Owen of @UMichOto @umichheadneck oncology program gave a great talk on #chordoma cell line establishment and work ongoing @umichmedicine. @NASBSorg @DrShirleySu @umichneuro @KhanNickalus @CFLabsResearch
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We’re excited about the launch of @bindresearch and look forward to working together to unlock new ways to drug TBXT.
I’m delighted to share that @ThomasLhr1, @gogulan_k, and I are launching @bindresearch, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠.
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RT @G_T_Heller: I’m delighted to share that @ThomasLhr1, @gogulan_k, and I are launching @bindresearch, a UK-based not-for-profit research….
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Interesting finding and possibly relevant to chordoma given frequent 9p21 loss.
(2/3).MSI-H → TTC37 mutations disrupt SKI function.9p21.3 deletion → FOCAD loss destabilizes the SKI complex. SKIc disruption -> PELO dependency. Both MSI-H and 9p21.3 deletion are frequent in many adult tumors making PELO a potential target for a large patient population.
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@xprize @scrollprize @cziscience @TheMarkFdn For more information about the TBXT Challenge visit or get in touch with us at TBXTchallenge@chordoma.org.
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@xprize @scrollprize We’re deeply grateful to those whose support and philanthropy is making the TBXT Challenge possible. Special thanks to @cziscience and @TheMarkFdn for helping us build the capabilities in CF Labs to enable TBXT drug discovery and evaluate submitted compounds!.
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Previously, we’ve had success using prizes to stimulate development of chordoma disease models and have been inspired by the successes of prizes for other purposes like the ALS Prize for Life, @xprize and @scrollprize. Now we want to see if a similar approach can drive.
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