Paul Thompson
@Pthompsn1018
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Chemical biologist, entrepreneur, maple leafs fan
Joined February 2014
RT @drrichjlaw: Wow. Investors in Padlock Therapeutics sue Bristol Myers Squibb over ‘milestone’ payments.The plaintiffs allege the pharma….
statnews.com
Investors in Padlock Therapeutics have accused Bristol Myers Squibb of reneging on payments of up to $450 million negotiated as part of a 2016 acquisition agreement.
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RT @UMassChan: BRIDGE Fund @UMassChan commits $2 million to take faculty research from the bench to the bedside: @….
umassmed.edu
BRIDGE Innovation and Business Development has set aside nearly $2 million in funding for six faculty-led research projects.
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RT @UMassChan_BMB: #newscience alert! BIG UPDATE! INCREASED PROTEIN CITRULLINATION IN MOUSE MODELS OF ALS ARE ALSO SEEN IN HUMAN ALS BRAIN….
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RT @lwalport: Very happy to be able to share this preprint from a fab collaboration with @MAChristoLab. It's been a long journey to get her….
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RT @ousitanio: Excited to share our latest article published in @plospathogens: #plospathogensauthor #citrullinatio….
journals.plos.org
Author summary HSV-1 is a common human pathogen that infects approximately 70% of the population for life. After infection, the virus remains dormant in sensory neurons but reactivates periodically,...
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Super cool new paper from the Weerapana lab!!!.Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics: Cell Chemical Biology
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RT @UofSC_Chem: Are you interested in graduate school? Then check out all the new research groups and the entire Department of Chemistry an….
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intriguing study further linking PAD6 to infertility. New explanation for infertility: eggs lacking a mysterious ‘lattice’
nature.com
Nature - The discovery of a ‘storage locker’ for essential proteins could explain some cases of infertility.
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RT @JebKeiper: #AtlasRetreat2023 @LifeSciVC’s Year In Review is sobering. Interesting to see small molecules (“smiracles”?) still dominat….
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RT @jasonsknight: 🕸️👀.Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice.https:/….
science.org
Targeting the innate immune system may be a way to prevent diabetic cardiovascular disease-associated complications.
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RT @kmartinod: The product of a wonderful 2-day conference on citrullination last year in Nottingham. Please reach out if interested in cop….
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RT @RSocPublishing: Citrullination is a chemical protein modification, which has gained great interest because it is associated with #autoi….
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RT @CarynOutten: Please RT and tell your biochemistry/molecular biology/chemical biology/neurobiology/neurochemistry postdocs to apply! We….
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4) These studies follow up on our earlier work showing that SARM1 undergoes a phase transition in vivo
elifesciences.org
The catalytic activity of SARM1, a key promoter of neuronal degeneration, is activated by >2000-fold by a phase transition.
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3) The key finding is that upon undergoing a liquid to solid phase transition, NMN agonizes SARM1 activity at concentrations as low as 5 micromolar versus 500 micromolar when in the liquid state. These concentrations of NMN are physiologically relevant.
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2) This study led by superstar graduate student Janneke Icso shows that SARM1 undergoes a phase transition that increases its sensitivity to NMN, an known agonist that increases SARM1 activity.
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1) Latest from the lab! A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels - Journal of Biological Chemistry
jbc.org
Axonal degeneration is a hallmark feature of neurodegenerative diseases. Activation of the NAD(P)ase sterile alpha and toll-interleukin receptor motif containing protein 1 (SARM1) is critical for...
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cool paper from @doc_jlmeier Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors | ACS Chemical Biology
pubs.acs.org
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like...
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RT @UMassChan_BMB: #newscience alert! We're working to take the STING out of diseases like #ALS, #lupus, & #SAVI. A new publication from @P….
umassmed.edu
Dr. Paul Thompson of the Biochemistry & Molecular Biotechnology department at UMass Chan Medical School recently published a newly discovered inhibitor of STING signaling that could be a promising...
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RT @FitzgeraldKate: Very excited to advance and improve on our STING inhibitors working with a great team @UMassChan @Pthompsn1018 @UMassCh….
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