Prof Sam El-Osta
@SamElOsta1
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Sam is an epigeneticist dedicated to understanding health and disease. Clinical importance over statistical significance. Baker Heart and Diabetes Institute.
Melbourne, Vic
Joined April 2020
What is the role of Set7 methyltransferase in diabetic glomerular endothelial cell damage in diabetic kidney disease?. This study shows Set7 regulates the mesenchymal to endothelial phenotypic switch.
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Stem cell derived islet therapy restores insulin in people living with T1D. 🔹 100% showed C-peptide response. 🔹 100% avoided severe hypos + HbA1c <7%. 🔹 83% achieved insulin independence at 1 year. 🔹 All received single infusion + immunosuppression.
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Still buzzing from the 20th IPITA Congress in Pisa!. Too many highlights to name, one standout was Dr. Deng’s talk on Chemical Reprogramming for Cell Fate. Stellar program & speakers, meeting new friends and staying at the historic Galilei residence, home of Galileo’s family!
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New 20yr data from Milan on islet transplantation alone in T1D:. ✅ 44% insulin independence (median 6 yrs). ✅ Graft survival up to 20 yrs. ✅ Subgroup (high islet dose + BAS/FK/Rapa): 73% insulin independence. ⚠️ Allosensitisation rose to 42% after immunosuppression withdrawal.
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Long-term outcomes of pancreatic islet transplantation alone in type 1 diabetes: a 20-year single-centre study in Italy. The Lancet Diabetes & Endocrinology
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RT @gabrieleschiat1: 🚨 Out now in Circulation Research 🚨.So proud with @mkontari to launch this Compendium on Interorgan Crosstalk in Heart….
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RT @mason_lab: "Scalable co-sequencing of RNA and DNA from individual nuclei" - cool new method!
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RT @ISHR_ES: Please all join our General Assembly @ishr2025 in Nara - room A&B today at 14:00! @ISHR_AUS @ISHR_NAS @ISHR_chinese
https://t.….
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RT @imadmnajm: Epigenetic changes affect the function of the glucose transporter DNA in endothelial cells from FCD2tissue….The role that de….
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*Diabetes impairs blood vessel growth, worsening PAD outcomes. *Study finds high glucose boosts SETD7, increasing SEMA3G-an angiogenesis blocker-restoring vessel formation in diabetic cells, mice, and patients. *Targeting SETD7 may offer a new epigenetic therapy for diabetic PAD.
We're thrilled to share the latest research from the @PaneniLab published in #Diabetes!📚Mohammed et al. have unveiled that histone methyltransferase SETD7 restores post-ischemic vascularization by transcriptional repression of Semaphorin-3G.🧪.Read more:
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RT @PaneniLab: Proud to share our latest work! Out today in @CircRes @CTECresearch @FrancescoPaneni @shafeeq_moham @NataliaAtzemian @Gorica….
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RT @FrancescoPaneni: Our lab has identified a new epigenetic mechanism and a druggable target in #HFpEF. Extremely thankful to my amazing t….
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RT @Cell_Metabolism: New! Online now: O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extrac….
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RT @tangming2005: 🧵 Should you integrate single-cell RNA-seq datasets or not?.You've got PBMCs from multiple donors. Merge them—or keep the….
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Check out this new @ClevelandClinic study uncovering glucose metabolism in focal cortical dysplasia is linked to epigenetic GLUT1 regulation. Congrats to Chaitali and team led by Imad Najm @imadmnajm @CleClinicNews.#epilepsy #neuroepigenetics #GLUT1 #FCD.
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RT @Cell_Metabolism: Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogra….
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RT @Cell_Metabolism: Lactate controls cancer stemness and plasticity through epigenetic regulation .
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RT @ProfJRMcMullen: Looking for a new research assistant to join our team @HRIAust . If you have an interest in the #heart and #cancer ple….
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RT @ScienceMagazine: In a new Science study, researchers introduce GAIA, a statistical approach that seeks to learn the geographic position….
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