Nathan Roy
@roybiolab
Followers
504
Following
4K
Media
45
Statuses
393
PI at SUNY Upstate Medical University. Trying to understand signaling that drives immune cell migration.
Syracuse, NY
Joined September 2018
New preprint alert!! In our last work we have found that Tissue stiffening primes migratory cell states by allowing histone serotonylation! #biomechanics #xenopus #chromatin #neuralcrest #devbio #cellmigration #frogpower
https://t.co/r5miQldHxh
biorxiv.org
Collective cell migration (CCM) is pivotal in several biological contexts, and posttranslational modifications of histones are essential to initiate this process[1][1]–[3][2]. Here, we show that a...
1
8
22
Buy the drybath beads for a thousand dollars, or go to ebay and order aluminum pull tabs for $35? I think you know the answer to that.
1
2
8
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint ( https://t.co/0F5uW36Yy1), led by the amazing Noam Zuela-Sopilniak and @julien_morival we show that cardiomyocyte-specific depletion of lamin A/C causes severe DCM. ...
2
6
27
Very proud of my spectacular graduate student Liz Kurtz @liz_kurtz_ on her first paper. More to come from her in the future!
Liz Kurtz @liz_kurtz_, Nathan Roy @roybiolab and colleagues find that the scaffold protein CasL restrains membrane blebbing and promotes T cell migration. Highlight: https://t.co/dmnuVgBOi2 Article: https://t.co/IOD09JDgZm
2
3
10
Check our new article in B cell mechanoresponses 💥 @Peaceiton @IsidoraRiobo @coffee_lipe @Jheim01309974 @Cabrera_R_FE @ContrerasTeemly @sarahdezperez @mattilalab
.@LabYuseff @uc_chile show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation https://t.co/9oNDESDNSt
1
6
14
🔬👨💻📰 #SReD is out! Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️ Brainchild of @afonsomendes92 and adventure w @christlet lab + friends. Check: https://t.co/bkP94oAr7M
2
31
108
Our Immune Cell Biology collection emphasizes cellular dynamics, immune regulation, and disease mechanisms. Explore the mechanisms of dendritic cell regulation, T cell migration, neutrophil spreading and macrophage motility in tumor invasion: https://t.co/m2vcqZHpRh
#AAI2025
1
5
17
Excited to share the study led by the talented Tia Brodeur during her fellowship in my lab. Single cell analysis of ovarian immune cells during homeostasis and hormonal flux reveals dynamic changes in NK and B cell populations in the periovulatory phase
biorxiv.org
The mammalian ovary is the dynamic end-organ of the hypothalamic pituitary ovarian axis. In this coordinated system, ovarian cells undergo continuous cycles of apoptosis, proliferation, and differe...
0
4
10
Faculty job opportunity! Two Empire Innovations Scholar positions at the Assoc. Professor level are open in our dept (@UpstateCDBio) and Biochem. Mol. Bio. dept @UpstateNews. Seeking funded faculty w. interests in microscopy and related areas. Apply at https://t.co/8jsihPubOE
1
8
13
Bumping up these ads. We are running two searches: one is for a tenure-track position in any area of cell or developmental biology and the other is for an associate professor with a research program using advanced microscopy, image analysis, biosensor development or related tools
Faculty job opportunity! Two Empire Innovations Scholar positions at the Assoc. Professor level are open in our dept (@UpstateCDBio) and Biochem. Mol. Bio. dept @UpstateNews. Seeking funded faculty w. interests in microscopy and related areas. Apply at https://t.co/8jsihPubOE
1
7
9
Our work on the role of endogenous electric fields in guiding collective cell migration in vivo is finally out @NatureMaterials ! https://t.co/UVEMt5ZGdl Congrats to all the authors, specially Fernando and @Sofia__Moreira from my lab #bioelectrics #devbio #cellmigration #xenopus
nature.com
Nature Materials - Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.
10
42
191
New tenure-track position at University of Vermont, Division of Pulmonary and Critical Care Medicine - just posted - looking for a basic researcher in immunology, lung, sepsis, and beyond! please RT
0
9
12
This work centers around the scaffold protein CasL and its unexpected role restricting membrane blebbing in migrating T cells. This work was led by the talented graduate student @liz_kurtz_ , who is just getting started!
0
0
2
It's a pleasure to share the first manuscript from my lab!
biorxiv.org
T cell migration into inflamed tissue is a key control point in the inflammatory response and relies on integrin interactions with their endothelial ligands. Here, we identify the signaling scaffold...
3
5
17
2024 NYIC - my first conference presentation! ❤️ a ton of fun and great science 🔬🦠🧬
1
2
10
We are hiring faculty! Any area of cell or developmental biology is of interest; current strengths include cytoskeleton, mechanobiology, microscopy. Join a friendly department in the beautiful upstate NY; K99/R00 not required. https://t.co/qZKffsMPwZ
1
62
85
Our paper describing the death grip cytotoxic T cells use to kill their prey is out in Science Immunology! Congratulations to @MedyoScientific and @Alex_H_Settle, our resident leukocyte topographers. https://t.co/3hFHmy1Pxa
science.org
Cytotoxic T cells form topographically complex, undulatory immune synapses with their targets to promote killing.
1
9
28
Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity. Great work from Minh Thanh. Experiments + Modeling. @syracusephysics Patteson, Schwarz, Zhang, Wu, and @SyracuseBmce Soman Groups. https://t.co/D4RSPZpzei
0
6
21
Anyone have a recommendation for a commercially available small tissue culture microscope with a solid state light source? I just want to look at GFP and RFP quickly but don't want to deal with a lamp. Any stand alone products like this?
1
0
1