Sven Rottenberg
@RottenbergSven
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scientist with special interest in understanding mechanisms of anti-cancer therapy resistance
Joined November 2019
RT @Rockdeme: Take a look inside a SARS-CoV-2-infected mouse lung with X-Pression! Our 3D reconstructions reveal changes in gene expression….
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RT @Rockdeme: Excited to share our new preprint! We map the spatiotemporal dynamics of therapy response & minimal residual disease in BRCA1….
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RT @Chapman_lab_UK: And that’s a wrap! Feeling inspired after hosting a week of excellent talks & discussions @ #EMBOdnaDamage24 with @LabL….
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RT @HanaHanzlikova: Dispensability of HPF1 for cellular removal of DNA single-strand breaks .Credits to Kristyna an….
academic.oup.com
Abstract. In response to DNA damage, the histone PARylation factor 1 (HPF1) regulates PARP1/2 activity, facilitating serine ADP-ribosylation of chromatin-a
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Happy to share our latest finding on H2AX promoting replication fork degradation and chemosensitivity in BRCA-deficient tumors.
nature.com
Nature Communications - Histone H2AX has a known role in DNA damage repair but interestingly, its loss is associated with resistance to poly(ADP-ribose) polymerase (PARP) inhibition in...
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RT @LabLegube: The Cape Sounio EMBO meeting on "The DNA Damage Response in cell physiology and diseases" is now open for registration! 👇 De….
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RT @LabLegube: Yes it will happen 🤩! EMBO DDR meeting in Sounio is not open yet for registration but see below a teaser. Save the date! 👇 h….
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RT @HanaHanzlikova: .Glad to see that the discovery of PARP-dependent ligation of OF might have an impact in clinic….
embopress.org
imageimageTargeting poly(ADP-ribose) glycohydrolase (PARG) is being explored as anti-cancer therapeutic strategy, and PARG loss may also contribute to resistance to PARP inhibitor (PARPi) treatment....
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RT @Rockdeme: Super excited to share the preprint of chrysalis, our method that identifies tissue compartments in #spatialtranscriptomics w….
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RT @skimomiks: how did long DNA molecules - 100 times longer than those usually sequenced in cancer - help us solve a paradox about BRCA de….
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RT @DiVirgilio_lab: 🥁🥁🥁. My lab just opened a call for a #PhDposition !. If you are passionate for. well, what we do. and would love….
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Interested in a PhD project on radioresistance in Bern? Check this out:
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RT @keith_caldecott: Dear all-new preprint of interest to the PARP field and neurodegenerative disease. First patient with PARP1 hereditary….
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RT @DNA_Repair_JC: FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.….
science.org
Functional genetic screens identify FIRRM/C1orf112 as a crucial factor for genome stability in the interstrand crosslink response.
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RT @jjonkers2: @Cancer_Cell Super proud of our latest Cancer Cell paper describing a massive amount of hard work performed by Stefan Hutten….
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RT @organoidscience: Dr. @RottenbergSven and team from @unibern established 3D #organoid cultures from canine mammary tumors as a tool to s….
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RT @HanaHanzlikova: Here we go! Nice collaboration with @keith_caldecott PARP inhibition impedes the maturation of nascent DNA strands duri….
nature.com
Nature Structural & Molecular Biology - Biochemical and cell-based assays reveal that PARP inhibitors impede the maturation of nascent DNA strands during DNA replication, and implicate...
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RT @Chapman_lab_UK: Fascinated by #DNArepair? Come work with us! We are looking for bright enthusiastic & motivated postdocs to join our te….
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