Sven Rottenberg
@RottenbergSven
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scientist with special interest in understanding mechanisms of anti-cancer therapy resistance
Joined November 2019
Take a look inside a SARS-CoV-2-infected mouse lung with X-Pression! Our 3D reconstructions reveal changes in gene expression programs across the entire organ, leveraging ST and micro-CT. Check out the details in our preprint: https://t.co/1QZS4kVaKW
#SpatialTranscriptomics
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Excited to share our new preprint! We map the spatiotemporal dynamics of therapy response & minimal residual disease in BRCA1;p53-deficient breast #cancer using #MultiOmics. We identify drug-tolerant EMT cancer cells, offering new therapeutic targets. 🔗 https://t.co/VostKuvNOw
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And that’s a wrap! Feeling inspired after hosting a week of excellent talks & discussions @ #EMBOdnaDamage24 with @LabLegube & @RottenbergSven. So grateful to the speakers & presenters who made it such a success & to @EMBO for support🙏. To beautiful Sounio, see you soon🤞❤️
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Dispensability of HPF1 for cellular removal of DNA single-strand breaks https://t.co/08renPjfeZ Credits to Kristyna and @cammila_cz and all other authors for this meticulous work on the "importance" of Ser-ADPr in SSBR :-)
academic.oup.com
Abstract. In response to DNA damage, the histone PARylation factor 1 (HPF1) regulates PARP1/2 activity, facilitating serine ADP-ribosylation of chromatin-a
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Happy to share our latest finding on H2AX promoting replication fork degradation and chemosensitivity in BRCA-deficient tumors https://t.co/q6Ydry042k
nature.com
Nature Communications - Histone H2AX has a known role in DNA damage repair but interestingly, its loss is associated with resistance to poly(ADP-ribose) polymerase (PARP) inhibition in...
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The Cape Sounio EMBO meeting on "The DNA Damage Response in cell physiology and diseases" is now open for registration! 👇 Deadline May 17th! https://t.co/njW3U4kYM3
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Yes it will happen 🤩! EMBO DDR meeting in Sounio is not open yet for registration but see below a teaser. Save the date! 👇
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https://t.co/rIaJoOMWQ4 Glad to see that the discovery of PARP-dependent ligation of OF might have an impact in clinics. Great work from @ChrisAndronikou and @cammila_cz and collaboration with @jjonkers and @RottenbergSven
embopress.org
imageimageTargeting poly(ADP-ribose) glycohydrolase (PARG) is being explored as anti-cancer therapeutic strategy, and PARG loss may also contribute to resistance to PARP inhibitor (PARPi) treatment....
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Super excited to share the preprint of chrysalis, our method that identifies tissue compartments in #spatialtranscriptomics without external reference. Preprint: https://t.co/WlJzMcj92k 🧵 (1/6)
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how did long DNA molecules - 100 times longer than those usually sequenced in cancer - help us solve a paradox about BRCA deficiency? read all about in our paper, out in @Nature today https://t.co/ajrIGJJbx7 👇🧵 1/
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🥁🥁🥁... My lab just opened a call for a #PhDposition ! If you are passionate for... well, what we do... and would love to join a totally COOL team 😎, then LOOK NO FURTHER !!! Additional info and link to application portal: https://t.co/eAiCRGt4Qw Please apply or RT 😆
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Interested in a PhD project on radioresistance in Bern? Check this out:
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Congratulations Hana, very well deserved Dr H 💃
I am delighted and honored to have been elected an EMBO member. I thank all my fellow EMBO members for their support and trust. Congratulations to all!
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Dear all-new preprint of interest to the PARP field and neurodegenerative disease. First patient with PARP1 hereditary mutations https://t.co/NuF5IGgRcS
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FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks. https://t.co/LTQfZBba81
science.org
Functional genetic screens identify FIRRM/C1orf112 as a crucial factor for genome stability in the interstrand crosslink response.
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@Cancer_Cell Super proud of our latest Cancer Cell paper describing a massive amount of hard work performed by Stefan Hutten et al. in close collaboration with Colinda Scheele! Big kudos to CRUK and KWF for funding this work, and to Oncode for funding our lab at the NKI!
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Dr. @RottenbergSven and team from @unibern established 3D #organoid cultures from canine mammary tumors as a tool to study #tumorigenesis and therapy response in a spontaneously developing mammary tumor model for #HumanBreastCancer. 📍 @SciReports 🔓 https://t.co/cLhYkfkCG0
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Here we go! Nice collaboration with @keith_caldecott PARP inhibition impedes the maturation of nascent DNA strands during DNA replication | Nature Structural & Molecular Biology
nature.com
Nature Structural & Molecular Biology - Biochemical and cell-based assays reveal that PARP inhibitors impede the maturation of nascent DNA strands during DNA replication, and implicate...
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Fascinated by #DNArepair? Come work with us! We are looking for bright enthusiastic & motivated postdocs to join our team. Projects will use genetics and reductionist approaches to understand why DSB repair deficiencies trigger human diseases & cancers:
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Still time to submit your abstract to this exciting meeting!
Abstract submission for the 11th conference on Responses to DNA Damage in Egmond aan Zee (March 27th - April 1st, 2022) has been extended to January 31st, 2022. Please submit your abstract for a poster / short talk to join the great list of speakers 👇 https://t.co/9DpEau7wq4
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