DNA Repair Articles
@DNA_Repair_JC
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Daily updates on DNA damage and repair.
Joined September 2022
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis.
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Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.
embopress.org
image image UNG glycosylase excises genomic chlorouracil from cells treated with 5‐chloro‐2′‐deoxyuridine (CldU), inducing template strand breaks and replication fork collapse. Cells lacking single...
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Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells.
pubs.acs.org
The base excision repair (BER) pathway is a frontline defender of genomic integrity and plays a central role in epigenetic regulation through its involvement in the erasure of 5-methylcytosine. This...
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Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells.
academic.oup.com
Abstract. Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death. In the absence of telomerase activity, activatio
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Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase.
academic.oup.com
ABSTRACT. Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine (C) or adenine (A), but no method for guanine (G
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Naturally mutagenic sequence diversity in a human type II topoisomerase.
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Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes.
nature.com
Cell Death & Disease - Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes
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Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation.
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ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics.
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Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway.
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Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology.
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Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures.
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Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding.
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ASH1L-MRG15 methyltransferase deposits H3K4me3 and FACT for damage verification in nucleotide excision repair.
nature.com
Nature Communications - Due to the naturally dense packing of the genome, DNA repair factors encounter a topologically very intricate cellular context. We describe how the human ASH1L protein...
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HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
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TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis.
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DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.
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DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage.
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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
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Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity.
onlinelibrary.wiley.com
By systematically analyzing the somatic mutation landscapes of 73 centenarians and 51 controls using whole genome sequencing, Wang et al. identified a number of genomic regions (viz., CSM-FRs) that...
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