DNA Repair Articles
@DNA_Repair_JC
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Daily updates on DNA damage and repair.
Joined September 2022
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis. https://t.co/f3KZUGOLsQ
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Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity. https://t.co/lfowJDzmcL
embopress.org
image image UNG glycosylase excises genomic chlorouracil from cells treated with 5‐chloro‐2′‐deoxyuridine (CldU), inducing template strand breaks and replication fork collapse. Cells lacking single...
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Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells. https://t.co/TIhGHXnLP3
pubs.acs.org
The base excision repair (BER) pathway is a frontline defender of genomic integrity and plays a central role in epigenetic regulation through its involvement in the erasure of 5-methylcytosine. This...
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Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells. https://t.co/XJMRoN1oxM
academic.oup.com
Abstract. Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death. In the absence of telomerase activity, activatio
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Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase. https://t.co/xWT4AiCUKR
academic.oup.com
ABSTRACT. Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine (C) or adenine (A), but no method for guanine (G
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Naturally mutagenic sequence diversity in a human type II topoisomerase. https://t.co/9qOscLtIN2
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Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes. https://t.co/fhs4KHrl2s
nature.com
Cell Death & Disease - Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes
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Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation. https://t.co/HcJFSnNldG
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ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics. https://t.co/VHrwNlxzha
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Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway. https://t.co/PihZ27Z8rS
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Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology. https://t.co/T3fM0wARLv
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Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures. https://t.co/h1REBybzpy
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Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding. https://t.co/Yuht1Zx5VG
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ASH1L-MRG15 methyltransferase deposits H3K4me3 and FACT for damage verification in nucleotide excision repair. https://t.co/zJtYPHp5z2
nature.com
Nature Communications - Due to the naturally dense packing of the genome, DNA repair factors encounter a topologically very intricate cellular context. We describe how the human ASH1L protein...
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HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway. https://t.co/OkKlciFhnR
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TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis. https://t.co/x6LcKf7VQP
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DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining. https://t.co/RLR6ohYvFA
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DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage. https://t.co/SlY52qofY5
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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression. https://t.co/gLXipCgCHO
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Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity. https://t.co/wvuwNFeIn3
onlinelibrary.wiley.com
By systematically analyzing the somatic mutation landscapes of 73 centenarians and 51 controls using whole genome sequencing, Wang et al. identified a number of genomic regions (viz., CSM-FRs) that...
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