Ravi Muddashetty Lab
@RaviMLab
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Neurons | Ribosomes | RNA
Bengaluru, India
Joined May 2020
🚨 Exciting new publication alert! 🧠Our lab uncovers how mGluR activation restores APOE4-induced deficits in neuronal protein synthesis and synaptic activity via the mTOR–pRPS6 pathway. Read more 👉 https://t.co/CugbFybrlN
#Neuroscience #Alzheimers #SynapticPlasticity
life-science-alliance.org
The E4 isoform of apolipoprotein (APOE4) is the most recognized risk factor for Alzheimer’s disease, implicated in early neurodegeneration and impaired synaptic plasticity. In neurons, exposure to...
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How does the brain shape how long and how well we live?🧠Join our Webinar as we dive into Brain Aging & Longevity with leading neuroscientists and innovators! 📅 4th Nov 2025 |🕓 4:00 PM IST Register now & drop your questions for our panelists: https://t.co/QHKKd6ZgDl
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A compelling illustration of the difference between mRNA abundance, ribosome density and protein abundance.
A cancer therapy targeting the interaction between metabolism & protein synthesis. Dietary restriction of arginine and proline depletes polyamines, which in turn causes ribosome stalling at codons with A in the third position. This shifts the balances towards cell ...
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In RNA Biology: FMRP regulates rRNA 2′O-methylation during neuronal differentiation. FMRP–snoRNA interactions shape ribosome epitranscriptomic states; loss of FMRP alters stepwise 2′O-Me dynamics, disrupting translation control in Fragile X Syndrome. https://t.co/ENfJRhD6FG
tandfonline.com
The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an autism ...
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HIRING JRF! Join our team at CBR for a project on 'Mitochondrial translation dysregulation in Alzheimer’s Disease.' Send your CV and two references to ravimshetty@cbr-iisc.ac.in by August 8, 2025. #Alzheimers #JRFHiring #Mitochondria
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Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain https://t.co/wb0Z6of0tY
#biorxiv_neursci
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The No Garland Neuroscience Meeting is back! Join us @tvmiiser from December 5-8, 2024. Follow @NGN_2024 for regular updates! 🧠Register & submit your abstracts now. @AmruthaSwamina1 & I can't wait to welcome all #neuroscience enthusiasts to our campus. https://t.co/pkFgOXgEdi
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Delighted to share our latest preprint led by @MNinochkaDsouza and @Naveenkcg which reveals FMRP's role in regulating rRNA 2’O-methylation during neuronal differentiation, impacting ribosome function and protein synthesis. @DPalakodeti @RaviMLab
biorxiv.org
The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an Autism...
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See our latest publication by @abinayar28
https://t.co/mmCN7KLe4N on how neurodegenerative stress facilitates toxic materials sharing with neighbours through membrane nanotubes. It is a product of great collaboration efforts. Thanks to @SivaramanLab @RaviManjithaya @RaviMLab.
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Excited to share our current findings published in @LSAjournal ! Congratulations to @R_Sarayu , Bindushree and Nisa. Well deserved!
This work highlights the different calcium channels involved in controlling protein synthesis in neurons, and shows the dysfunction of this process in Alzheimer's disease neurons @CBR_IISc @RaviMLab @R_Sarayu
https://t.co/M8IZF38yAC
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This work highlights the different calcium channels involved in controlling protein synthesis in neurons, and shows the dysfunction of this process in Alzheimer's disease neurons @CBR_IISc @RaviMLab @R_Sarayu
https://t.co/M8IZF38yAC
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A potential therapeutic target for ASD: downregulation of histone acetylation (could be a signature of SYNGAP1-related asd #autism #brain #drug #disease #therapy
biorxiv.org
Sporadic heterozygous mutations in SYNGAP1 affects social and emotional behaviour that are often observed in intellectual disability (ID) and autism spectrum disorder (ASD). Although neurophysiolog...
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Happy to host postdocs in our group--we work on genetics of Indian populations in the context of aging and neurodegeneration. Please reach out if interested!
Call for applications under @DBTIndia Research Associateship Program (Call -I) are open for pursuing post-doctoral research in Biotechnology and Life Science at any university/ institutions across #India. For more information, please visit:Â https://t.co/5lK6hG9bxi
@unescorcb
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New paper from @cytoskeletonlab Drisya Dileep @AmmuDris in collaboration with Tabish Syed, Kaleem Siddiqi @mcgillu @quorumetrix @Dhan_inStem
https://t.co/hKkUSB5eVu We combine tissue clearing, volumetric imaging & computer vision to obtain micron-scale heart myofiber organization
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Happy to share our new article on the #CACNA1A variant from our group. https://t.co/9Oq7gl8ylZ
#Freudegroup #epilepsy #CACNA1A #epilepsyeducation
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Curious to know more about cell-cell transfer through Tunneling nanotubes and their effect on alpha- synuclein induced toxicity? Check out the link in the thread @PhDVoice @AcademicChatter @OpenAcademics @ThePhDPlace @PhD_Genie #AcademicTwitter
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We are delighted that our faculty member @BratatiKahali has been recommended for the IA Intermediate Fellowship, which will help harness the power of large-scale #genetic analyses to study the interplay between metabolic risk factors and cognition to gain insights into #dementia.
DBT/Wellcome Trust India Alliance is proud to announce its recently recommended Fellowship #Awardees for #EarlyCareer #Fellowship (2022-2023 round) #IntermediateFellowship, and #SeniorFellowship (June 2023 round) in #BasicBiomedicalResearch 🔗know more – https://t.co/vyC2hzznEr
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We are proud to share that Dr Justin Joseph, a postdoc in the lab of @ChinnaAdaikkan, has been recommended for the @India_Alliance Early Career Fellowship. His project is aimed at developing & optimising a brain-computer interface to modulate neural activity in #Alzheimersdisease
DBT/Wellcome Trust India Alliance is proud to announce its recently recommended Fellowship #Awardees for #EarlyCareer #Fellowship (2022-2023 round) #IntermediateFellowship, and #SeniorFellowship (June 2023 round) in #BasicBiomedicalResearch 🔗know more – https://t.co/vyC2hzznEr
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Finally!!! Tuning ribosomes and cell differentiation with one single methylation - check out our latest publication from @therealLundLab : https://t.co/bKiqkm54UL
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