Rachel Darnell
@RachelDarnell14
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Wife, mother, and Research Fellow in molecular microbiology. My research interests involve understanding the development of antimicrobial resistance.
Joined April 2019
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So happy our pre-print on daptomycin mechanism of action is now out! Here, we present three main findings: i) daptomycin does not form large membrane pores in either B. subtilis or S. aureus, (1/3)
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action https://t.co/vYYmHxj8mX
#biorxiv_micrbio
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Thank you to the SAB team & @BBSRC Portfolio Manager for joining our meeting. Lots of new ideas, practical advice and encouraging feedback as we enter the 3rd year of this exciting project.
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Super excited that our paper on isoniazid resistance in M. tuberculosis is now published in @NatureComms . Massive effort from all involved, especially lead author Cecilia Wang!! https://t.co/twXSGL8LQs
nature.com
Nature Communications - In this work, authors utilise genome-wide CRISPRi screening to identify vulnerabilities in isoniazid-resistant strains of Mycobacterium tuberculosis.
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Fully-funded @DiMeN_DTP PhD opportunity available in my lab to investigate novel DNA damage repair processes using next generation sequencing and microscopy techniques (co-supervised by @acdarby & @MicKasia). Please RT and contact me if interested. https://t.co/7a9TYDiHNl
findaphd.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Deciphering the impact of DNA damage repair on Staphylococcal infections. at Newcastle University, listed on FindAPhD.com
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Excited to share my first co-corresponding opinion piece written in collaboration with the wonderful @MojganRabiey
https://t.co/eiMqFzF64q. We cover our thoughts on advancements in phage biocontrol for agricultural pathogens and where the field might develop next.
enviromicro-journals.onlinelibrary.wiley.com
Bacteriophages, phage-derived proteins and organic acids offer potential as biocontrols for bacterial pathogens that affect fruit production. Our opinion piece outlines current developments in phage...
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Excited to share our new paper. https://t.co/H2XvUUia9B🚨🦠 This highlights the importance of infection control and AMR surveillance. #AMR #InfectionPrevention #Healthcare #Fiji @JamesUssher4 @DonaldWilsonFJ @HealthFij @MOHFiji @microtago @FNUFiji
frontiersin.org
IntroductionThere are multiple ongoing outbreaks of carbapenem resistant Acinetobacter baumannii (CRAb) infection in Fiji’s hospitals. CRAb is able to coloni...
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Today is the beginning of the Postdoc Appreciation Week in the UK! Big shout out to our amazing postdocs working on @AVERTproject. You are key drivers in delivering research excellence and we want to thank you for all you do! #LovePostdocs #NPAW2024 #ECRs
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Couple of recent publications from our group!! 1) Awesome work from post-doc Will Jowsey showing how drug-resistance in Mtb alters tolerance to cell wall inhibitors! https://t.co/wT3A0nXff8 (1/2)
academic.oup.com
AbstractBackground. A limited ability to eliminate drug-resistant strains of Mycobacterium tuberculosis is a major contributor to the morbidity of TB. Comp
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We are looking for an Assistant Research Fellow to join the group and work on #phages as part of our @MBIEsci funded work. You must have right to live and work in NZ to be eligible. Details below https://t.co/jLOmcXaOqH please share
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Our paper on the mechanism of phage sensing and restriction by toxin-antitoxin-chaperone (TAC) systems is out in @cellhostmicrobe! We study two antiphage TACs: HigBAC and CmdTAC. @gem__atkinson @HenrikStrahl @AHarms485 @medfak_LU @lunduniversity
https://t.co/yjThAzxX86
cell.com
Toxin-antitoxin-chaperone (TAC) systems have been shown to mediate antiphage defense via as-yet unexplored mechanisms. Focusing on two TACs encoded by Escherichia coli prophages—HigBAC and CmdTAC—M...
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Had a great time networking and learning about all things Bacillus at #BACELL2024 in #Dubrovnik with the @HenrikStrahl lab and @GebhardLab
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After my PhD, I went through a horrible transition to industry. Today I am at a conference with colleagues I class as friends presenting work I am so so passionate about ❤️
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A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis by @CaraAdolph, Chen-Yi Cheung, Gregory M. Cook et al at @otago @microtago @MWC_CoRE
cell.com
Adolph et al. report on a small molecule inhibitor, BB2-50F, that rapidly sterilizes M. tuberculosis and potentiates current TB drugs. Through target identification and mechanism of action studies,...
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Anyone with a passion or curiosity for metabolism and enterococci come down and chat at #Microbio24! 🧫🧬🥳@MicrobioSoc
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Thank you @Prof_Sarge for the opportunity to present at the #NewcastleMicrobiologyOlympiad it was great to put so many names to faces!
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