Charles Winterhalter
@Ch_Winterhalter
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@wellcometrust Early Career Fellow working on bacterial DNA damage repair @CBCB_Newcastle @UniofNewcastle. @winterhalterlab.bsky.social
Joined April 2014
Still time left to apply and join my team on a fully funded PhD project investigating dynamics of the bacterial DNA damage response in live cells using microscopy & genomics.
Engineering anti-CRISPR/Cas systems to control the DNA damage response in live bacterial cells. Supervised by @Ch_Winterhalter, Alistair Darby and @MicKasia.
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Excited to share with you the story that enabled me to start my own lab: what happens when the bacterial DNA replication machinery encounters single-strand discontinuities on template DNA? What is required for DNA break repair and replication restart?
biorxiv.org
Many antibiotics indirectly generate reactive oxygen species (ROS) that can damage bacterial genomes. Oxidised nucleobases become genotoxic when they are targeted for repair through excision,...
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RT @Lis_Lowe: Come and do a PhD with me and @DrPaulJamesUK to find some new exciting enzymes! #glycotime .
findaphd.com
PhD Project - New lysins for medically and environmentally important Mycobacteriales at Newcastle University, listed on FindAPhD.com
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RT @RuaMicro: Fully funded PhD position available to join our team! We will focus on untangling the mechanisms used by antibiotic resistant….
findaphd.com
PhD Project - Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction at Newcastle University, listed on FindAPhD.com
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RT @GraingerLab: If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're o….
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Navigating through academia as an ECR can be challenging. @CKYLau and @CorreiaMeloC will tell us more about their experience of becoming group leaders and how to achieve this on 12th Feb @BiochemSoc. Free registration at .
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RT @dghilarov: Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/….
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RT @AKTooke: Happy to share this story from my PhD @foster_lab & @steverenshaw - with @becky31290 in Ken Bayles’ lab & @JosiePyrah - we sho….
link.springer.com
Current Microbiology - Oxacillin (bactericidal) and tetracycline (bacteriostatic) are clinically relevant antibiotics that are routinely prescribed to treat Staphylococcus aureus infections but not...
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Fully-funded @DiMeN_DTP PhD opportunity available in my lab to investigate novel DNA damage repair processes using next generation sequencing and microscopy techniques (co-supervised by @acdarby & @MicKasia). Please RT and contact me if interested.
findaphd.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Deciphering the impact of DNA damage repair on Staphylococcal infections. at Newcastle University, listed on FindAPhD.com
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RT @foster_lab: We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to met….
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RT @UniversitiesUK: As well as improving our daily lives, university research contributes £54 BILLION to the UK economy and supports 121k j….
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RT @Tung_BK_Le: DTP PhD studentship available in our lab. Start: Oct 2025. Apply: now-24th Nov 2024 . Taming the Viral Wolf: Cracking the….
biodtp.norwichresearchpark.ac.uk
LE_J25DTP
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If you haven't already, check out the Hachiman phage defence system characterised by the @doudna_lab @CellCellPress. Inspiring work and scary 'phantom' cells (perfect for Halloween!) 👏 .
cell.com
Hachiman is a nuclease-helicase complex that protects against bacteriophage infection by destroying both viral and host genomes.
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RT @SusanSchlimpert: Please RT. 1x postdoc and 1xPhD position available in our group to study the role of NLR-like proteins in cellular dev….
biodtp.norwichresearchpark.ac.uk
SCHLIMPERT_J25DTP
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Super nice Single Molecule Bacteriology meeting in the Cotswolds. Thanks to the organisers, looking forward to new collaborations and see you at the next event!.
That's a wrap on the 91st Harden: Single Molecule Bacteriology event! .Huge thanks to everyone who joined us for insightful talks, lively discussions and lots of fun! #biochemevent
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Looking forward to day 2 at the UK DNA Replication Meeting for more amazing talks! Come and find me this evening at Poster 4 to hear all about replisome arrest and replication restart from nicks @BiochemSoc #BioChemEvent.
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Registration for the Single Molecule Bacteriology III conference is open, I am honoured to be invited speaker and looking forward to meet you all there!.
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RT @nussenza: A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_rapha….
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RT @dghilarov: A rewarding collaboration revealing an entirely novel inhibitor pocket in DNA gyrase. Inhibition mechanism determined via b….
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