Mohammed Hanzala
@ProteoMatrix
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Research Specialist @RockefellerUniv | previously at @UMCG_ERIBA | Mass spectrometry/Proteomics |
Manhattan, New York
Joined March 2011
🔬 New research from Oxford Chemistry advances proteomics by combining multiple fragmentation strategies within a single mass spectrometry platform. Read more:
chem.ox.ac.uk
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Many years in the making, great to see this paper from my @RockefellerUniv colleague Brian Chait! A nature-inspired ion trap for parallel manipulation of ions on a massive scale:
science.org
A nature-inspired ion trap enabling massively parallel mass spectrometry.
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These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @TShamorkina @T_Kadava @LPerezPaneda and Albert Heck https://t.co/v3fq55HlNJ
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How does the LINE-1 retrotransposon find its targets in the genome? It tends to insert at TTTTT↓AA sequences, but why is not well undestood. Excited to share my lab's first senior author paper since moving to Brown! 🧵 on our new paper in JBC: https://t.co/J2IVI1hrXG
jbc.org
Long interspersed element 1 (LINE-1, L1) is a eukaryotic retrotransposon that propagates through an RNA intermediate. Its mutagenic insertion mechanism, target-primed reverse transcription (TPRT),...
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Delighted that @teerap16's paper on MAP-MS is out! https://t.co/tGpEOarO6u It changes how precursor ions accumulate in Orbitraps to achieve 2Ă— dynamic range without consequences, improving DDA and DIA. It's a free instrument upgrade requiring no special software for Lumos on up!
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A LEGO model of Orbitrap Excedion Pro mass spec with a Spectronaut astronaut on top… coolest science souvenir ever! Thank you @ChromSolutions & @biognosys
#spectronuat #orbitrap
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Time and time again, it's always the same picture. DIA-NN controls FDR correctly as data reliability has been the main goal at DIA-NN's conception back in 2017 and a priority since then. Data from a very nice paper introducing the Thin-diaPASEF concept: https://t.co/bHg3jx8Ywx.
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We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us! https://t.co/3beLRHphKU
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Nielsen et al. track an elusive protein that, over millions of years, has shaped ~45% of the human genome. Despite this profound impact, the protein has evaded detection by conventional methods — making it one of biology’s compelling molecular mysteries. https://t.co/sZiXoz9Mui
link.springer.com
Mobile DNA - Both the expression and activities of LINE-1 (L1) retrotransposons are known to occur in numerous cell-types and are implicated in pathobiological contexts such as aging-related...
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🧬 The FASEB Mobile DNA conference abstract deadline is fast approaching! 📅 Please register and submit your abstract by May 25th! 🔗 https://t.co/1a9cghAT9X
#FASEB #MobileDNA #Genomics #Transposons #Conference
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We’re Hiring: We are looking for a motivated Postdoctoral Researcher for a three-year funded position to contribute to cutting-edge melanoma research as part of the PerMel-AI consortium, funded by EP PerMed. See more details in https://t.co/3PrkssG2ky
#Proteomics #Bioinformatics
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We are hiring! Interested in identifying new therapeutic molecules for obesity and metabolic disorders. Join my lab @csiriiim One project position for biology and one for chemistry @DrShowkatR41235 Apply ⬇️ https://t.co/WKAro0lFPI
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We are excited to share our new Nature Methods paper describing the Chip-Tip workflow for single-cell proteomics identifying >5,000 proteins in single cells, enabling PTM analysis without enrichment and throughput of up to 120 single cell samples per day: https://t.co/ZI19WxwzlK
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Identification numbers and FDR control of Spectronaut 18 vs DIA-NN 1.9 as benchmarked by Jesper Olsen and colleagues (Nature Methods) https://t.co/YjH2KVtrGh
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The Mahabaleshwar seminar series set up By Obaid Siddiqi is back! The 43rd version of the student-centric discussion based series covers membranes & organelles. Website: https://t.co/vMOZnugxxd Please RT If this area interests you do consider coming to Alibaug
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Never in my wildest dreams would I have imagined that the humble DIA tool, I wrote as an intern project at Biognosys, would evolve into what Spectronaut is today. And that fills me with tremendous pride and a feeling of accomplishment.
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X-omics training school On July 16 and 17 2024 X-omics will organize an in person workshop “Protein variant detection with proteogenomics data integration”. Please find the program and more information below. #xomics #training #workshop #proteogenomics #dataintegration
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Friends, #FragPipe 22 has been released, and it's a big update! diaTracer enables spectrum-centric analysis of diaPASEF data. Skyline integration. Koina server for more deep-learning prediction options. DDA+ mode for ddaPASEF. DIA glycoproteomics and new chemoproteomics workflows
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Don't miss our Spectronaut 19 launch seminar on Tuesday morning at #ASMS24. We made a lot of really cool improvements to directDIA, quantification and workflows in general. A shame I can't be there in person this year.
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Here’s a snap of TIC from HeLa digest. #TeamMassSpec what could be the reason for this unusual dip in the chromatographic pattern?
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