Peng Xu Profile
Peng Xu

@PengXu_Sci

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Scientist studying Parkinson's disease @PDClab @Yale. Former Alzheimer's disease researcher at Greengard lab @RockefellerUniv and PhD with @dmvirshup @DukeNUS

New Haven, CT
Joined September 2009
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@PengXu_Sci
Peng Xu
2 months
VPS13A and VPS13C, founding members of the bridge-like lipid transfer protein family, are split from a single ancestor gene during vertebrate evolution. Do they have overlapping functions? We addressed it at the organism level using KO mouse models with surprising findings: 1/6
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@PengXu_Sci
Peng Xu
14 days
RT @YaleNeuro: Meet this week's #TraineeTuesday, Michael Hanna, PhD, @LifeCerealMikey!.Mike is a postdoc in the @PDClab & will start as an….
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@PengXu_Sci
Peng Xu
16 days
RT @GUmschweif: Excited to share our publication in Translational Psychiatry! Nrsn2-KO mice reveal exciting insights into the basis of stre….
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nature.com
Translational Psychiatry - Characterization of Neurensin-2 knockout mice: insights into stress-resilience mechanisms
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@PengXu_Sci
Peng Xu
22 days
RT @zuhangsheng: Pleased to share our invited News & Views piece in @NatMetabolism, highlighting the emerging role of lipid metabolism in f….
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@PengXu_Sci
Peng Xu
1 month
RT @NeuralCell: The @karchlab demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in hiPSC-derived #m….
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@PengXu_Sci
Peng Xu
1 month
RT @JGrutzendler: 1/ I am happy to share our latest publication in Nature Neuro We present the first subcellula….
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@PengXu_Sci
Peng Xu
1 month
RT @BerroLab: Wondering how/whether AI can be helpful in your mathematical models in cell biology? Whether you are a biologist, physicist,….
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@PengXu_Sci
Peng Xu
1 month
RT @Krauselab_Yale: 🚨 @elonmusk, we need your attention! 🚨. A proposed 40% cut to the NIH budget will have catastrophic consequences for p….
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@PengXu_Sci
Peng Xu
2 months
RT @LifeCerealMikey: 📢The Hanna Lab is coming to the Department of Biochemistry and Molecular Biology at Penn State in January 2026! We’ll….
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@PengXu_Sci
Peng Xu
2 months
RT @YaleWestCampus: Julien Berro thinks about the force – particularly around the 'cytoskeleton' scaffold inside our cells. The member of t….
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@PengXu_Sci
Peng Xu
2 months
RT @ShoSuzuki20: My lab has an open position for a postdoc, technician, and a PhD student. If you have an interest, please feel free to con….
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@PengXu_Sci
Peng Xu
2 months
RT @RobertoZoncu: Beautiful work on PCSK9 as driver of metastatic organ targeting in pancreatic cancer by @GillesRademaker and @rushika_per….
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@PengXu_Sci
Peng Xu
2 months
RT @KavliAtYale: 🚨HAPPENING TOMORROW🚨 Don’t miss the 2025 ✨@KavliAtYale Distinguished Lecture✨ with Erika Holzbaur, PhD (@PennMedicine @Pen….
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@PengXu_Sci
Peng Xu
2 months
Activation of RIGI pathway may be caused by organelle leakage due to their lipid membrane defects, supporting the concept that impaired intracellular lipid transport may activate innate immunity; neuroinflammation derived from such activation plays a role in neurodegeneration 5/n.
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@PengXu_Sci
Peng Xu
2 months
RNAseq of isolated S0 cells shows the upregulation of interferon stimulated genes in DKO. Specifically, cytosolic dsRNA sensor RIGI and MDA5 are upregulated at both RNA and protein levels in DKO fetal liver as well as human erythroblastic K562 cells. 4/6.
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@PengXu_Sci
Peng Xu
2 months
DKO embryos are smaller and paler with hematopoietic defects. FACS analysis further identified that S0 erythroid precursors failed to differentiate/mature in the DKO fetal liver, the key site for hematopoiesis at this developmental stage. 3/6.
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@PengXu_Sci
Peng Xu
2 months
Loss-of-function mutations of VPS13A and VPS13C in humans cause distinct neurodegenerative diseases, chorea-acanthocytosis and Parkinson’s disease/DLB, respectively. However, no major defects are observed in single gene KO mice. Unexpectedly, DKO leads to embryonic lethality. 2/6.
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