Pawel Mikulski
@PawelMikulski
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Group Leader & Institute Prof @IMol_Institute | Ex @UniofOxford, @JohnInnesCentre, @MSCActions | Curious about chromatin and cellular memory 🧬
Warsaw
Joined July 2018
Thrilled to share that our story found a home in Nature Structural & Molecular Biology @NatureSMB ! 🎉. 🔗 We hope this forms a contribution in understanding the #epigenetics mechanisms in #ImmuneSignalling. 🧵(1/8)
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Poszukujemy lab managera do naszego nowo przeniesionego laboratorium w @NenckiInstitute . Zapraszam do aplikowania i sprawdzenia profilu pod:
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RT @OstuniLab: We are looking for 1 mid-career scientist (and postdocs) willing to join us as SR-Tiget in Milan. Basic and translational im….
fondazionetelethon.it
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It's been a collaborative project with a fantastic team, done in @BiochemOxford and finished during review in @IMol_Institute. Congratulations to all authors, thank you to the reviewers, editors, as well as 🇬🇧🇵🇱 funding bodies.
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Overall, we propose that transcriptional memory mechanism is conceptually based on: . - accelerator (retention of specific active histone marks).- brake (local loss of repressive Polycomb mark).- clutch (cis-regulatory element controlling memory output). 🧵(7/8).
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Since the preprint, we found that the establishment of the memory is widespread in cell population irrespective of expression status of reporter memory gene and added clustering of epigenomic features at memory genes with unsupervised learning. 🧵(6/8).
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We also found that gene hyper-activation during IFNγ restimulation is repressed by a cis-regulatory silencer. This silencer forms long-range chromatin loops, which reset post-stimulation and are not epigenetically maintained. 🧵(5/8).
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We found it’s driven by:.- Post-stimulus retention of active histone marks (H3K4me1, H3K14ac, H4K16ac).- Local loss of repressive Polycomb mark (H3K27me3). Strangely, H3K27me3 initially accumulates during first IFNγ stimulation when genes are activated. 🧵(4/8).
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This IFNγ-induced transcriptional memory is:.- Reversible.- Epigenetically maintained for <14 generations.- Distinct from chronic IFNγ signaling. What’s the mechanism behind it? . 🧵(3/8).
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IFNγ—a key regulator of innate immunity—activates hundreds to thousands of genes. Remarkably, IFNγ restimulation in later cell generations hyper-activates specific immune genes (e.g., GBPs). How do progeny cells inherit and recall this past stimulation?. 🧵(2/8).
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RT @EricTopol: Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their….
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RT @MarcinGrzy: I am looking for a postdoc to work on maize and wheat transcriptomics and metabolomics at the population scale. Feel free t….
euraxess.ec.europa.eu
The Dean of the Faculty of Biology of the University of Warsaw invites applications for the position of Assistant Professor Reference No. WB-K-3/2025 Position Assistant Professor Employee group...
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Praca dla osoby zainteresowanej omicsami, GWASem i genetyka populacyjna w roślinach:
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Happy to contribute to this excellent story about heterochromatin role in centromere maintenance, led by @ben_carty93 ! Heterochrom. boundaries control centromere expansion, drift & number! Great usage of induced neocentromere model and modern epigenomics across the labs🥳.
What is the molecular basis for maintaining centromere size and position? In a great collaboration with @NAltemose @GiuntaLab and @FachinettiLab labs, we investigate the long standing question of how heterochromatin maintains centromere size/position!
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RT @ManelEsteller: I am looking forward to delivering tomorrow lecture on the #Epigenetic #Hallmarks of #Cancer at the amazing MD Anderson….
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My fav historical podcast covers '39 invasion to Poland. Crucial to recall, given that the same arguments are being used in the current conflicts. Unjustifiable atrocities, 5.5mln PL deaths, unpreparedness or silence of young, re-established republic and its allies. Never again.
🔫HITLER'S WAR ON POLAND: THE FALL OF WARSAW🔫. 🇵🇱𝘓𝘦𝘵 𝘴𝘭𝘪𝘱 𝘵𝘩𝘦 𝘥𝘰𝘨𝘴 𝘰𝘧 𝘸𝘢𝘳. Hitler launches a devastating war against Poland, seeking to eliminate its culture and history as well as its army. In the west, France outnumbers Germany 5 to 1 . will they attack?
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RT @NenckiInstitute: 📢 We are happy to announce that two new excellent 𝐆𝐫𝐨𝐮𝐩 𝐋𝐞𝐚𝐝𝐞𝐫𝐬 have been selected to 𝐜𝐫𝐞𝐚𝐭𝐞 𝐨𝐰𝐧 𝐥𝐚𝐛𝐨𝐫𝐚𝐭𝐨𝐫𝐢𝐞𝐬 𝐚𝐭 𝐭𝐡𝐞 𝐍….
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RT @kawecki_maciej: Brawo! Chciałbym złożyć serdeczne gratulacje @UniWarszawski! Uniwersytet Warszawski zajął pierwsze miejsce na świecie w….
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RT @IMol_Institute: At @IMol_Institute , we like to share our passion for science with society. Follow the link below to hear how Dr. @Cies….
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RT @EricTopol: New @Nature .A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells..
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