First Pathania Lab paper in @CD_AACR: https://t.co/dIecm8mZMB. We developed 16 mouse models of various subtypes of pediatric high-grade glioma— mirroring their different H3 mutant contexts, anatomical compartmentalizations and co-segregating partner alterations. Thread below 1/17

Thanks to all those who helped us get going in Cambridge and looking forward to getting stuck in at Oxford soon!

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned! https://t.co/DqQRW3zfbS

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!

'Night science' is what you do when you're not sure what's the question.

Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA) Why is it such a big deal? When trialled (in women in South Africa and Uganda) there were 0 HIV infections 🧵

I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗:

We are walking the Ullswater Way with @OscarsCharity in May. Learn more and donate here: https://t.co/5IBDxX9cd2 #braintumours #childhoodcancer #cancer

Too many people take biomedical innovation for granted.

"More than 99% of new drug approvals (2010-2019) were funded by NIH. Why dismantle the engine that made the U.S. a world leader in innovation and drug development ? #DoNotDefundScience

It would’ve been a show of strength for the President of the United States to bring the elected leader of Ukraine to the Oval Office and engage with him in a dignified way.   But you would never know that after President Trump’s shameful display. Putin must be overjoyed with

In 1993 Ukraine *gave up their nukes* in exchange for a guarantee of future protection from the USA. If the USA isn't going to keep their word (which is a scummy beta move) then give them back the same amount of nukes that were destroyed so they can protect their own selves.

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

1/Metastasis can stay dormant for years before reactivating and becoming lethal. But what wakes them up? A new study uncovers a fascinating mechanism involving epigenetics and immune suppression. Let’s break it down! 🧵 #metastasis #cancer #oncology #science #Immunology #dormancy

Fine, here we go. First let's start with some baseline expectations. Pancreatic cancer is scary, 5y survival is ~10%. So if you see a trial with an apparent survival asymptote at ~50% then certainly *something* is happening, right?

#mRNAvaccines for #PancreaticCancer (PDAC) PART4 1. Out today in @Nature https://t.co/NhpkJeaQYb 🧵👇🏽 [1/23]

Trump's lawyers are absolutely flailing in the courts right now

after ten years of research, they are here scientists created mice with human-like telomeres that experience real cellular aging. this might be the biggest breakthrough in longevity science in decades 1/

*Every single* cure for a disease ultimately flowed from basic exploratory research. Stopping basic research is like stopping the mountain rains and expecting rivers of cures to still flow. Examples: 1) studying saliva of Gila monster -> GLP1's 2) studying funghi -> first

The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. https://t.co/i05me2SXI4 1/n

Buon Anno!