Parham Lab
@ParhamLab
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@StanfordMed Studying the biology, genetics and evolution of the Major Histocompatability Complex (MHC) and other immune molecules.
Stanford University, CA
Joined August 2015
Amazing paper by Dr Emily Wroblewski on Malaria-driven adaptation of MHC class I in wild bonobo populations - read it here!
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Very excited to say our paper exploring CD56neg NK cells has been published! Through a combination of meta-analysis, and both CyTOF and scRNAseq datasets, we investigate this unique population of NK cells linked to HIV-1 and other chronic virus infections
frontiersin.org
Human NK cells are usually defined as CD3-CD56+ lymphocytes. However, a CD56-CD16+ (CD56neg) lymphocyte population that displays NK-associated markers expand...
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New paper with @PN0rmski, Gabriel Santpere, @ArcadiNavarro, and @MarcoTelford. Does peptide-specific immune recognition shape herpesvirus protein diversity? https://t.co/bGyDXbc2Qa
pnas.org
Herpesviruses are ubiquitous, genetically diverse DNA viruses, with long-term presence in humans associated with infrequent but significant patholo...
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#JI_TopRead: From researchers @stanfordimmuno @ParhamLab @PN0rmski @HLAB8 | Following Transplantation for Acute Myelogenous #Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01 #ReadTheJI
https://t.co/aG74VARJFR
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Our latest release: HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity. @DjaoudZ.
annualreviews.org
In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a peptide and take it to the cell surface for surveillance by lymphocytes. These include natural killer (NK)...
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Our latest release from @DjaoudZ 'Dimorphism in the TCRγ-chain repertoire defines 2 types of human immunity to Epstein-Barr virus' https://t.co/mhHNr3PgS0
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Here’s our new paper — On genetic diversity in the human immune system — five years of research, led by postdoc @pippa_kennedy, and many collaborators. In @scisignal
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Natural Killer cell research in @scisignal ? Well isn’t that just a perfect Xmas present!
The new issue of Science Signaling is out now! Research explores how a cancer drug attenuates lung fibrosis in mice, how a common chemotherapy can promote cancer cell migration, and genetic diversity in natural killer cell receptors. https://t.co/axE0Dsa6pT
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Enhancing NK cell missing self responses with in vitro education by KIR3DL1. Our latest paper out now in @LSAjournal
life-science-alliance.org
During development, NK cells are “educated” to respond aggressively to cells with low surface expression of HLA class I, a hallmark of malignant and infected cells. The mechanism of education...
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Altfeld and colleagues identify the NK cell receptor NKp44 as directly interacting with the class II HLA-DP in a partially peptide-dependent manner and with functional consequences for NK cell activity https://t.co/hK4eT0QcLC
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Report from the Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop: novel insights on KIR polymorphism, ligand recognition, expression and f... - PubMed - NCBI Hoping to attend the next one in 2020, hosted by @PN0rmski
pubmed.ncbi.nlm.nih.gov
The Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop was held in Camogli (Genoa, Italy) in October 2018. This congress brought together 113 participants working on KIR field. Fifty-eight...
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Our new perspective on the exciting research from @mjwsim and others, an encouraging step for identifying orphan KIR ligands and a role for NK cells in defense against bacterial infection.
A natural killer cell receptor takes sharp aim at the world of bacteria.
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Review on how population genetics can greatly inform questions in human immunology @CellCellPress, see https://t.co/0JT3jsn1Xl... and a great Cell's 2019 Special Issue: Unraveling the Human Genome! See https://t.co/enccsIJM81
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Our latest paper in collaboration with @PN0rmski and others out now, KIR and HLA class I diversity in Sub saharan African populations, 28 novel KIR alleles but surprisingly no new HLA alleles
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Super excited to see our paper finally out today @PNAS! A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s disease
pnas.org
Parkinson’s disease (PD) is a neurodegenerative disease in which genetic risk has been mapped to HLA, but precise allelic associations have been di...
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Our new review with Dr Emily Wroblewski is out now, studying Hominid species to understand 'the evolutionary dance between two cooperating systems of MHC class I and NK cell receptors' https://t.co/lJagLvM74V
@WUSTLbioanthro
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HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor https://t.co/a93Rw3p8o5
#biorxiv_immuno
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1/x. NK cell education is tightly linked to remodelling of the lysosomal compartment. Educated NK cells carry a greater cytotoxic payload in large dense-core secretory lysosomes (See T shirt). https://t.co/nzGeR4MDZo
@jodegoodridge @CIM_Sweden @UiO_LifeSci @NatureComms
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Thanks to Christina Tato @chanzuck biohub for very nice highlight of my 2013 CyTOF study with @ParhamLab and Catherine Blish published @NatRevImmunol. 1st report of human NK cells by CyTOF. https://t.co/8z4xOUVVqv
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Wow! So nice to see that the complex genetics of NK cell education revealed by @AmirHorowitz has a role in AML and Immunotherapy. Makes perfect sense!
Read our latest paper on how the HLA-B -21 dimorphism impacts on NK cell function in AML! @thoren_lab @Hallner90 @hussein_brwa #NKcell
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