Ocampo Lab
@OcampoLab
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We are revolutionizing the way we think about aging by reprogramming organisms to live longer lives.
Joined February 2019
Excited to share our new publication! We previously showed that age reversal can be achieved using transcription factor-based reprogramming. Now, we demonstrate that it can also be done with chemical cocktails to achieve lifespan extension! https://t.co/hxgIhAOW0U
link.springer.com
EMBO Molecular Medicine - The dedifferentiation of somatic cells into a pluripotent state by cellular reprogramming coincides with a reversal of age-associated molecular hallmarks. Although...
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We also acknowledge the important work of dedicated groups and recent publications who help move reprogramming towards future translational applications 🚀 @gladyshev_lab @davidasinclair
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In vivo, this new chemical approach to cellular reprogramming significantly extended C. elegans lifespan, healthspan, and even reproductive span, with no observed toxicity! Thank you to the team, @schlucas_ @trickpaine @sarapico7 @kgiperez and collaborators!
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In this proof-of-concept, we demonstrate the capacity of partial chemical reprogramming to ameliorate phenotypes of aging and present a reduced cocktail capable of mirroring OSKM-induced rejuvenation in multiple cell types, without inducing dedifferentiation.
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With this demonstration of chemical reprogramming, we built on the rejuvenating effects of transcription factor reprogramming, known to improve aging hallmarks and extend lifespan.
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Please retweet! If you wanted to live longer and healthier, would you rather take a drug that:?
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Please retweet! If you wanted to live longer and healthier, would you rather take a drug that:?
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Beautiful paper and amazing organism. Rejuvenation by regeneration, even at the distal non-regenerated sites. In vivo reprogramming? So much aging biology still to be discovered…
Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN
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Now the supplement AG1 is in airport vending machines. At right is the complete list of peer-reviewed, independent research studies that show an improvement in health outcomes.
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Beyond the Hallmarks: What are we missing in ageing research? At the Global Conference on Gerophysics 2025, I posed several uncomfortable—but necessary—questions: 🔹 Why haven't we don better than caloric restriction for lifespan extension in mammals—after 50 years? 🔹 Have
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Ambitious and realistic mission, amazing and talented team, great company run in an unconventional and magical tech/biotech way by Joe. Happy to work with them and watch their fast progress. Learn more about Retro Biosciencies. https://t.co/sNPNNOtD5f
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Interested on developing therapies based on in vivo reprogramming. New exciting position at Retro. Amazing company, incredible mission, and outstanding team! https://t.co/3F0aRnSMnI
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"We owe almost all our knowledge not to those who have agreed but to those who have differed." - Charles Caleb Colton
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Lifetime age‐related changes in clinical laboratory results, aging clocks and mortality predictors in 2412 Golden Retrievers 🐶 https://t.co/Ja2BCyd4dA
onlinelibrary.wiley.com
We analyzed clinical data from 2412 Golden Retrievers to examine age-related changes and their association with mortality. A biological aging clock using blood markers achieved R = 0.78 but did not...
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Comprehensive evaluation of lifespan‐extending molecules in C. elegans 🐛 https://t.co/X0RzM0Dr01
onlinelibrary.wiley.com
We evaluated 16 of the most frequently reported lifespan-extending molecules in C. elegans, examining their effects on lifespan with live and UV-killed OP50. We assessed the compounds' impact on...
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And to celebrate...🎉🎉 2x news papers from our work at @epiterna_ and @OcampoLab published today in @AgingCell ! 👏👏
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Very honored that our 2016 Cell paper on in vivo reprogramming and aging has been selected by Cell as one of the exceptional scientific works of the last 10 years! Happy to see how this field of research is growing. Thanks to everyone that made this landmark paper possible.👏👏👏
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1/ 🧵Announcing CORHORT 6 of the Longevity Biotech Fellowship —the most hardcore community of longevity accelerationists! Join 700 members working to SOLVE aging entirely. ⌛️Deadline: Mar 14 Kickoff Retreat: Mar 31 - Apr 4 in Berkeley. 👉Apply: https://t.co/1fuIo0jZ5r
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Our Applied AI team at @RetroBio_ + some @OpenAI homies working together for a few month have created GPT4b-micro, a sequence-based model for, among other things, protein design!
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OpenAI has created an AI model for longevity science https://t.co/3eoq1w1b4U Thank you @sama 👨🏻⚕️
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