Ameya Kulkarni, PhD 👨🔬
@mr_genetics
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Neuroscience, 🧬 Omics, and 🧠 Aging at @JNJInnovMed 🎓 @ChicagoBooth, @EinsteinMed, @NCState
Chicago, IL | Mumbai, India
Joined August 2015
#TopDownloadedArticle @AgingCell Top 10% among articles published in 2022. So happy to see the impact of our work @mr_genetics @NirBarzilaiMD @EinsteinMed @MontefioreEndo @EinsteinDeptMed
https://t.co/ngGGs2juAK
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The FAST (Finding Aging biomarkers by Searching existing Trials) Initiative has received an @impetusgrants grant to support its aims of establishing biomarkers to advance development of biomarkers for clinical trials in aging. @Danbelsky and I are excited! https://t.co/plIVWMZSlq
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Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 Chandrayaan-3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3
#Ch3
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How a PhD looks like from a supervisor's perspective... https://t.co/HrejAmoV7x
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It was so fun to see this race to everyone’s favorite hypothesis for AD pathology in real-time at #AAIC22
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Today in partnership with @emblebi, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: https://t.co/GjVES2pBFY 1/
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It's here–the deepest, sharpest infrared view of the universe to date: Webb's First Deep Field. Previewed by @POTUS on July 11, it shows galaxies once invisible to us. The full set of @NASAWebb's first full-color images & data will be revealed July 12: https://t.co/63zxpNDi4I
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🆕 @NatureGenet The discovery of 42 new genomic loci associated with Alzheimer's disease. Remarkable progress in the genomic underpinnings of the disease with nothing to show for an effective treatment yet https://t.co/0KAfkHGKMy
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Our scoring was based on clinical and preclinical evidence of ↑ healthspan indicators and ↓ mortality, as well as targeting the hallmarks of aging. Top candidates- SGLT2 inhibitors and metformin #aging #longevity #healthspan #geroscience #clinicaltrials #drugdiscovery #FDA
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Excited to share our work published in @AgingCell summarizing top FDA-approved drugs that can be repurposed as gerotherapeutics / geroprotectors Amazing collaboration with @SandraAleksicMD, David Berger, Felipe Sierra, @george_kuchel and @NirBarzilaiMD
https://t.co/h5ANs7wedj
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Geroscientists often speak of “hallmarks of aging”. To become a hallmark, we need to show 1) it changes with aging and 2) fixing it (with any of a variety of tools e.g. genetics, drugs, nutrients) will improve both healthspan and life span in mammals (pre-clinical animal models).
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Our new review has recently been published! https://t.co/N5bP4rxZ7q Covering the current state of single-cell omics & imaging technologies, & computational methods to perform integrative analyses of these datatypes to discover new insights, with case-studies from #aging
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Thrilled to be a part of this collaboration!
Excited to share our recent findings showing a progressive fibrotic muscle phenotype in patients with CKD that is dialysis-responsive. Fantastic team effort! https://t.co/luck4JtvW1
@JCI_insight @CBrightwellPhD @mr_genetics @UKYCMB @EinsteinMed @MonteNephrology
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This perspective covers how metformin attenuates the hallmarks of aging and highlights its therapeutic utility https://t.co/8ZVN93EilM
#openaccess #1YearAgo @mr_genetics
cell.com
Metformin is the first drug to be tested for its age-targeting effects in a large clinical trial. In this perspective, Kulkarni et al. review how metformin acts on its primary and secondary targets...
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'Science Startups, Who's Hiring?' (June) Last month I made a thread to help scientists / others find cool roles at startups. Seemed helpful, so doing again! Science startups -- reply with 1 tweet on your mission + open roles. Everyone -- please RT so more people see! (🧵 1/2)
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The history of the covid vaccines, by Tony Fauci https://t.co/tz4KC1ygRU Crediting @kkariko @WeissmanLab @BarneyGrahamMD @WardLab1 @KizzyPhD @McLellan_Lab and others for all the background work that led to this biomedical triumph @ScienceMagazine
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