Humans and ecosystems are constantly exposed to complex “chemical cocktails” that accumulate in bodies, wildlife, and the environment, yet current regulatory systems mainly assess risks on a substance-by-substance basis. In a new #SciencePolicyForum, researchers argue the need

Diet alters maternal microbiome, increasing offspring susceptibility to metabolic, inflammatory & immune-related diseases @Claradelaroque & @BenoitChassaing review the "invisible heritance" in @MicrobiomeJ: https://t.co/rBWEOZW6Q4

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice https://t.co/eZsHUGa5Yq

A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far. Learn more on #WorldAnimalDay: https://t.co/yXmctCX6PA @NewsfromScience

"The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve" https://t.co/AYuJ2C5UOi @cellhostmicrobe @PittDeptofMed Eldin Jašarević & colleagues

APA Statement on White House Announcement on Autism https://t.co/S5bf8MycQu

The use of some drugs (*which are not taken as antibiotics*!) altered the gut microbiome and made the host more susceptible to infection. 2 recent papers discussed in this @CellChemBiol Spotlight. https://t.co/rH01ZAOQVk

Microbiota drives sickle cell disease pain Sickle cell disease mice have excessive heme catabolites, fewer bacteria metabolizing bilirubin & low A. muciniphila. A. muciniphila or TRPM2 inhibitors (blocking bilirubin signals) reduce SCD pain @KateSadlerPhD https://t.co/O32Pv6blgk

Why do we sleep? And how? The 2 theories, broken down https://t.co/NfVw6XFbXE @NeuroCellPress

Rubisco is (arguably) the most abundant protein on Earth. (LPP surely comes close, right?) It’s an enzyme that fixes CO₂ into sugars during photosynthesis. Unfortunately, as most people learn in school, Rubisco is inefficient. Sometimes it confuses O₂ for CO₂ and wastes

Ruminococcus gnavus may serve as a key target for weight loss This research paper sheds light on the main mechanisms involved: https://t.co/z0sbEV3rNE

Lactobacilli encompass more than 300 species and are one of the most studied bacteria in humans and agriculture This review updates biology, applications, and host interactions relevant across all levels of the food scale @NatureRevMicro: https://t.co/J2rXY8AGgZ

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥

11.36 Hiroshima bombs. Every second. Our planet is boiling on the stove. The lid is on the pan. And our politics, our media & our lives, are in the pocket of an industry profiting from cranking the heat ever higher & higher. Unsustainable. Unsurvivable. Insane.

🤯Three (!!!) new papers today in @ScienceMagazine on the application of generative AI for the de novo design of peptide/HLA binding molecules! Completely unique 3D structure and binding mode compared with natural TCRs and TCR mimics! Links to papers 👇

"Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering" #GutMicrobiome #MicrobiomeEngineering @ErikBakkeren & colleagues

In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. The approach showed rapid and sustained immune reprogramming in preclinical models,

Out today from the Schwartz lab! A new way to study cell-cell communication from spatial transcriptomics data. Cell Neural Networks on Spatial Transcriptomics (CellNEST) can detect both signals between individual cells and relay networks of communication. https://t.co/bb0fwtp5ep

State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis

Let us introduce a new subspecies: ✨Catenibacterium mitsuokai subsp. tridentinum✨ Plus, we also propose a taxonomic reclassification of publicly available reference genomes belonging to the C. mitsuokai sp. More details ⬇️