MendjanLab
@MendjanLab
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human cardiogenesis | congenital heart defects self-organization | bridge molecules-cells-tissues training a new generation of scientists
IMBA, Vienna, Austria
Joined July 2017
Two years ago, we reported for the first time on #cardioids. Now, our team, led by two fantastic Ph.D. students, Alison and Clara, developed multi-chamber cardioids representing all the major regions of the human embryonic heart (atria, LV, RV, OFT, AVC) https://t.co/fJqE5ErYXU
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Force regulation of myogenesis by Tono, a BTB-Zn finger transcriptional regulator, which forms droplets after acute high pressure application. It responds in 1 minute :) - in yellow in the nuclei https://t.co/cdbNQwPj3j Congrats to Xu Zhang and @JrmAvellaneda #Drosophila #muscle
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Beyond thrilled to present our first (!) work @TheCrick! A tour de force by @tobyandrews et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating... https://t.co/RghtQtmYxF
Pumped to share our latest and first (!) work from @_Priya_R lab @TheCrick! Using the powers of #zebrafish, we uncover how multiscale mechanochemical coupling drives morphological and functional maturation of the developing heart 🫀 Stay tuned for the🧵 https://t.co/0MxXSef9bJ
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Very excited to see our new paper online @Nature, where @justuskleifeld @Patricia_Rothe_ and myself decipher the molecular choreography for how disassembly of the spliceosome begins. This was a great collaboration between the @plaschka_lab and @LCochella lab @IMPvienna.
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'The Mechanics of building functional organs - our take on this fundamental problem. We discuss general design rules building complex 3D geometries, advocate for a holistic understanding of morphogenesis by embracing the complexity of embryonic development. https://t.co/hZyvqxuWgT
How do embryos build organs with the right shape, size and function to keep our bodies ticking?🫀🫁👀 @_Priya_R and I give our take here, in a rollercoaster ride from local cell behaviors to organ-scale physiology and back https://t.co/GtcL6jYijv
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Congratulations to Clara Schmidt, @MendjanLab, who successfully defended her PhD thesis titled “Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects!”
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Meet EcoBot the professional weeder. The Machine Learning, Solar powered apparatus that can run for the entire day pulling weeds. Replaces expensive in every possible way, herbicides.
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Elly Tanaka will be IMBA’s new Scientific Director, heading the institute from April 2024 onwards. Elly Tanaka is a renowned researcher, who studies the regeneration of complex body parts. Welcome, Elly!
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Our paper describing Bioframe, a python library for working with genomic intervals, was just accepted!
academic.oup.com
AbstractMotivation. Genomic intervals are one of the most prevalent data structures in computational genome biology, and used to represent features ranging
Check out bioframe ( https://t.co/BGzBXFjJhB), a library for working with genomic interval #dataframes in #python and #pandas!!
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What a beautiful sight - children with Microscopes, curiosity in their eyes learning the wonders of Developmental Biology! Terrific outreach event organised by @InSDB_79 and fantastic students at @NCBS_Bangalore. Great start to InSDB 2024!
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Our new data-driven mathematical model of sarcomere assembly is now out. All the math was done by our fantastic collaborators in Dresden @friedrich_group @PoLDresden @IBDMmarseille @ClaraMSidor @BDehapiot
https://t.co/gaaP6lmqTp
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What graduate degree should you go for? The MBA, the MD, the JD, or the PhD? The PhD is unique - it has to be said - for teaching both critical reasoning and the creative process of discovery; skills that prepare you for anything you’d then want to do.
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Our latest release on placental microvasculature..Just in time for the holidays! @LabHaase
science.org
Advanced 3D fetoplacental-like vascular model reveals improved barrier function and matrix remodeling in response to flow.
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One decade after starting this journey, our collaborative paper with @Gibson_lab is finally out: https://t.co/0o4xuMSEZF. It reports chromosome assemblies of the related sea anemones @Nematostella and Scolanthus callimorphus. Will be an important resource for the community.
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Is there a better way to make PGCs in culture than with disorganised EBs and signalling cocktails? In our latest pub @Dev_journal we show that mouse 'gastruloids' make beautiful PGCs... 😍 [as also seen by others] (1/6) https://t.co/5ysnCYWC8F
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Why do we get certain diseases whereas others do not exist? This new book builds a foundation for systems medicine. Starting from basic laws, it derives why hormone, immune and aging circuits are built the way the are, culminating in a periodic table of diseases.
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Great study in @CellCellPress from our virologist colleagues @puchhammer et al & neurologists of the @MedUni_Wien. Bravo!! 👏 Specific Epstein-Barr virus determinants and immune responses by NK & T cells implicated in the risk for #multiplesclerosis. https://t.co/aGYZJbSSHJ
cell.com
Human genetic pre-disposition, as well as human cytomegalovirus and Epstein-Barr virus-encoded genetic variants, affect distinct protective immune responses against autoimmune cells and define the...
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Cannot recommend this enough!
Our laboratory for blastoid development and implantation is seeking a postdoctoral fellow to work with us on human embryogenesis. Our core-funded laboratory is located at the IMBA Institute of the Austrian Academy of Sciences in amazing Vienna. Please reTweet and get in touch!
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An interactive resource of molecular signalling in the developing human haematopoietic stem cell niche Read this Human Development Article by Edie Crosse @edie_crosse, Alexander Medvinsky @EdinUni_CRM and colleagues: https://t.co/hWnWGMyy6n
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