Melanie Weilert
@MelanieWeilert
Followers
147
Following
1K
Media
14
Statuses
159
bioinformatics, deep learning, genomics, @ZeitlingerLab ((all views are mine alone))
Kansas City, MO
Joined December 2018
RT @pkoo562: *Easter egg alert* NOT in the published paper. We also benchmarked Evo 2 and while it did better than other gLMs (consistent t….
0
11
0
Pretty pleased with what I’ve seen inside this model (aka sequence rules learned), some of their predictions better recapitulate our CRISPR experiments in mouse than our own, smaller models. Excited to see the release!.
Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.
0
5
24
RT @jmschreiber91: Released a new version of my little data processing tool, `bam2bw`. As you might expect, it goes directly from BAM to un….
0
9
0
RT @FukayaLab: Thank you very much @JuliaZeitlinger for inviting me to speak at the Wednesday lecture series! I got a lot of nice suggestio….
0
3
0
RT @AMathelier: 🎉 Excited to share the peer-reviewed version of our manuscript describing COBIND, a tool for revealing TF co-binding patter….
0
32
0
RT @kaelanbrennan: It was an honor to defend my PhD thesis today @ScienceStowers. I am so appreciative of my advisor @JuliaZeitlinger for h….
0
3
0
RT @skummerf: Excellent talk by @michaelhoffman predicting transcription factor binding. Old school motif-based approaches are not the answ….
0
22
0
RT @ScienceStowers: Last week we kicked off our first #OpenMicScience of the summer with presentations from Amanda Lawlor, A.J. Treichel, a….
0
2
0
RT @jmschreiber91: Attributions are invaluable in genomics for identifying the drivers of model predictions, but it's easy to make a mistak….
github.com
Biological sequence analysis for the modern age. Contribute to jmschrei/tangermeme development by creating an account on GitHub.
0
10
0
RT @anshulkundaje: Check out ProCapNet by @kellycochra, a robust, local sequence context deep learning model of base-resolution transcripti….
biorxiv.org
Despite extensive characterization of mammalian Pol II transcription, the DNA sequence determinants of transcription initiation at a third of human promoters and most enhancers remain poorly unders...
0
30
0
RT @snaqvi1990: Our latest - how does DNA sequence dictate the chromatin response to changing transcription factor levels? 1/n. https://t.c….
biorxiv.org
Deep learning approaches have made significant advances in predicting cell type-specific chromatin patterns from the identity and arrangement of transcription factor (TF) binding motifs. However,...
0
53
0
RT @lpachter: The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs.….
0
381
0
The sequence syntax that boosts TF binding also transfers to their signaling TF partners. Excellent work, @08Kats05 !.
In our latest work spearheaded by Khyati Dalal @08Kats05 , we use interpretable deep learning of genomic sequence information to tackle a long-standing question: How do signaling pathways regulate transcription in a cell-type-specific fashion? ( (1/8)
0
1
9
RT @suragnair: Excited to share work with co-first author @immoameen. Gene regulation is a delicate balance b/w cis-regulatory sequence & T….
biorxiv.org
Ectopic expression of OCT4 , SOX2 , KLF4 and MYC (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially...
0
40
0
RT @anshulkundaje: Check out our latest work led by @suragnair & @immoameen using neural nets to dissect the interplay of TF stoichiometry,….
biorxiv.org
Ectopic expression of OCT4 , SOX2 , KLF4 and MYC (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially...
0
55
0
Gorgeous paper, @suragnair ! Fascinated by the nature of low-affinity OctSox enrichment across transient peaks during reprogramming. Very useful work! .
biorxiv.org
Ectopic expression of OCT4 , SOX2 , KLF4 and MYC (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially...
1
0
3
RT @Loubiere20: Happy to share my postdoc work about enhancer-enhancer cooperativity! Find out more at
biorxiv.org
Genomic enhancers are key transcriptional regulators which, upon the binding of sequence-specific transcription factors, activate their cognate target promoters. Although enhancers have been extens...
0
18
0
RT @ScienceStowers: There is so much talk lately about #ArtificialIntelligence (#AI) – but what exactly is it? @MelanieWeilert, Bioinformat….
stowers.org
A bioinformatician’s journey using AI at the Stowers Institute for Medical Research
0
2
0