Mehrotra Parul
@MehrotraPa
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Assistant Professor @ IIT Delhi
New Delhi, India
Joined June 2022
RT @Lab_AmitSinghal: Great start of #EMBOtuberculosis @EMBO @ccmb_csir Day 1 - Mtb's phenotypic variation @SassettiLab Neeraj Dhar @Giulia_….
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Happy to have been part of this fascinating story at the edge of futuristic science- uncovering geroprotectors using a novel AI platform! @ahuja_77 #AgeXtend.
nature.com
Nature Aging - Arora et al. present AgeXtend, an explainable artificial intelligence-based platform that leverages bioactivity data to predict geroprotectors. They validate potential geroprotectors...
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RT @Kubes_Lab: Exciting new findings!! Thrilled to share our latest work in @SciImmunology which uncovers how restricted access of newborn….
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What an incredible piece of work from.@calico. The giant mouse study explains .1) How the terms “healthy" & "long life” are more nuanced and less interchangeable than we like to imagine. 2) Why/how Dietary Restriction/Fasting might help.
nature.com
Nature - Health effects of dietary restriction are uncoupled from longevity.
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A beautiful story from the @Andersonbuglab!!.@Ravi_Research. Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury: Cell Host & Microbe
cell.com
Anderson et al. demonstrate that host cell death drives dysbiosis and disease following chemotherapy. Intestinal epithelial cell apoptosis and the release of soluble metabolites promote Enterobacte...
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RT @Nature: Nature research paper: Lysosomes drive the piecemeal removal of mitochondrial inner membrane
nature.com
Nature - We show that cytosolic inner mitochondrial membrane vesicles, devoid of outer mitochondrial membrane or mitochondrial matrix, are formed during resting state and directly herniate into...
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RT @NImmunology: 📢Call for Applications!. @NImmunology is hosting an "Advanced #Immunology Course" in October for PhD scholars, postdocs, &….
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RT @_kaiwenchen: A number of new studies on gasdermin were published recently. @broz_lab and I put together a review to summarise and discu….
nature.com
Nature Cell Biology - Gasdermins are a family of proteins that form membrane pores and elicit pyroptosis. This Review discusses recent work highlighting their regulation and emerging biological...
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RT @Lo_Zanzi: #ImmunoCannibalism! #EveryCellIsAnImmuneCell! @ElaineFuchsLab &co show @Nature that stem cells sense lipids released by apopt….
nature.com
Nature - The spatiotemporal activation of phagocytosis by hair follicle cells is orchestrated by lipids released from surrounding apoptotic cells and retinoids released by healthy cells.
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This paper from @Lammermann_Lab is Bomb!! Entire neutrophils getting trapped by Mast cells to enhance functionality!. Reads like beautiful science and feels like an alien abduction movie!.@mpi_ie .
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How does #macrophagee #metabolism respond so incredibly fast to TLR triggers? @v_hornung lab have the forst answers- its not just transcription. Phosphorylation of PFKL begins go steer the metabolic switch!.
#WeekendRead! #ImmunometabolismPower! @hornung_lab @XiaoMei38942536 &co show @NatureComms that the phosphorylation of the #glycolitic enzyme PFKL balances HIF1alpha-dependent IL1b production vs ROS induction in macrophages!
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RT @KannegantiLab: Out today @CellCellPress: @BalaTejashiva and Nagakannan Pandian with @ThiruKanneganti and team @StJudeResearch identifie….
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RT @StJudeResearch: New research by @ThiruKanneganti in @CellCellPress reveals NLRC5 acts as an innate immune sensor and cell death regulat….
stjude.org
Learn about immunology research from the St. Jude laboratory of Thirumala-Devi Kanneganti, PhD, that revealed the function of the NLRC5 innate immune sensor.
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Such a nice opinion piece by @ThiruKanneganti @KannegantiLab covering our publication on Pyroptotic secretome!.
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RT @TomVBerghe: Check this out! Our last translational ferroptosis paper from excellent PhD student. Ferroptosis is a targetable detrimenta….
nature.com
Cell Death & Differentiation - Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease
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Such an important piece of information for those interested in metabolomics!! . @VAInstitute.
nature.com
Nature Communications - Metabolite extraction with organic solvents is assumed to remove/denature proteins. Here, the authors uncover a vast landscape of >1,000 proteins in metabolite...
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Cryo-EM structure and description of how #Bedaquiline binds to ATP-Synthase of both host and #mtb!! Incredibly similar binding sites.
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RT @Andersonbuglab: Fantastic work from @MehrotraPa in @kodiravi lab. I was fortunate enough to watch this project come together from start….
nature.com
Nature - Defining the composition of the secretome of pyroptotic macrophages reveals the involvement of the component factors in wound healing.
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