Out today @J_Immunol from first authors @bhesh82 & Mohi Choudhury: .✅NLRP3-dependent cell death occurs in CASP1- & GSDMD-deficient cells with LPS + ATP, suggesting cell death pathway other than pyroptosis.✅Led us to identify NLRP3-PANoptosome in WT cells.

🎊🥳Congratulations to everyone on the Highly Cited Researchers 2024 list @Clarivate, but a special CONGRATS to the Kanneganti lab alumni/staff on the list:.@rajukarki16.@SiMingMan1.RK Subbarao Malireddi (Mrk).We are so proud of you, and your impactful work!🎊🥳.#HighlyCited2024.

RT @anandparas: Join us on 21st November for another exciting InflammaZoom session, where I'll be hosting Serge Mostowy (@MostowyLab) and @….

RT @CaitlinZebley: Thrilled to announce our latest publication in @ScienceMagazine describing a reverse-translation study that defines the….

RT @StJudeResearch: New research shows that disrupting the Asxl1 gene in T cells boosts response to immunotherapy and improves long-term tu….

Excited to see our review discussing inflammasomes in #health and #disease, including their roles in PANoptosomes & cell death, in Current Opinion in Immunology @ElsevierConnect @ImmunologyNews. Congrats Vinod & @ThiruKanneganti! @StJudeResearch.

Excited for the @FASEBorg #GTSCR meeting, which will be filled with great discussions about GI host-microbe interactions, inflammation, immunity, cancers, & more. If you are attending, come see @ThiruKanneganti give the keynote address tomorrow evening!

It was great to work with @SiMingMan1 on this review for @NatureCellBio to discuss how dying #cells are sensed and the physiological impact of how cells die. Significant implications across the #disease spectrum. Check it out! @StJudeResearch.

RT @SiMingMan1: 🔱🌊NLRC5 PANoptosome is Aquaman of the Dead Sea. Check out our Research Highlight @cell_res to see why! .

New resource for the field! #Protocol @Curr_Protocols using genetic or inhibitor-based approaches to differentiate innate immune cell death pathways. Thanks for putting this together @RebeccaTweedell, Taylor Hibler, and @ThiruKanneganti @StJudeResearch!

RT @StJudeResearch: New research by @ThiruKanneganti in @CellCellPress reveals NLRC5 acts as an innate immune sensor and cell death regulat….

@BalaTejashiva @MallRaghvendra @rummansarkar @RebeccaTweedell @ShondraP_Miller @ThiruKanneganti Also, Omkar Indari = @OIndari on Twitter!.

Congratulations & thank you to first authors @BalaTejashiva and Nagakannan Pandian and the team, Hee Jin Kim, Hadia Abdelaal, @MallRaghvendra, Omkar Indari, @rummansarkar, @RebeccaTweedell, Emily Alonzo, Jonathon Klein, @ShondraP_Miller, Peter Vogel, and @ThiruKanneganti!👏🙏🎉.

The team found that NLRC5 was critical for pathology across inflammatory diseases, including hemolytic disease, #colitis, and #HLH models. The findings suggest targeting NLRC5, or other molecules in this pathway, has therapeutic potential in hemolytic and inflammatory #disease.

Heme release is often associated with hemolytic diseases (like #sicklecelldisease & #malaria), but many infectious & inflammatory diseases, including #SARSCoV2 & others, cause red blood cells to break apart and spill their contents, releasing heme to activate innate immunity.

NLRC5 then went on to induce the formation of a PANoptosome complex that contained an NLR network, with NLRP12 and the famous #NLRP3 also present. This led to inflammatory cell death.

This study found new functions for an enigmatic innate immune sensor, NLRC5. In response to heme and specific components of #infection (PAMPs) or cellular damage (#TNF), as well as depletion of the energy storage molecule NAD+, NLRC5 expression was upregulated.

Out today @CellCellPress: @BalaTejashiva and Nagakannan Pandian with @ThiruKanneganti and team @StJudeResearch identified NLRC5 as an innate #immune sensor of NAD+ depletion that drives inflammatory cell death, PANoptosis. Thread👇

Come see our fearless leader and amazing mentor @ThiruKanneganti present @ImmunologyAAI #AAI2024 at 1:15 today in W375B! She’ll give an overview of her historic work and highlight some of our new, exciting findings! Excited to see everyone there!

Excited to attend @ImmunologyAAI #Immunology2024! If you are here, too, check out our #postdoc job posting on the job board (, and come see @ThiruKanneganti present Sunday @ 1:15! Looking forward to seeing everyone and hearing all the exciting discoveries!.